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Reviewed, UniProtKB/Swiss-Prot Q64148 (CP3AA_MESAU)

Last modified September 2, 2008. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 3A10
    EC=1.14.13.94
Alternative name(s):
    CYPIIIA10
    Lithocholate 6-beta-hydroxylase
      Short name=6 beta-hydroxylase
Gene names
Name: CYP3A10
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Mesocricetus

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Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Catalyzes the 6 beta-hydroxylation of lithocholic acid and steroid hormones.

Catalytic activity

Lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + NADP(+) + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Developmental stage

Expressed only in male hamsters.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
NADP
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 503503Cytochrome P450 3A10

Sites

Metal binding4421Iron (heme axial ligand) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q64148-1 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: D4D24FEE87FD7F51

FASTA50357,693
        10         20         30         40         50         60 
MELIPNLSIE TWVLLAISLV LIYIYGTYSH GTFKKLGIPG PKPLPFFGTI LGYHDGTWKF 

        70         80         90        100        110        120 
DETCYKKYGK IWGFYDGRVP VLAIADPEII KTVLVKECYS NFTNRRSFGP VGFMKKSITI 

       130        140        150        160        170        180 
SKDEEWKRLR TLLSPAFTSG KLKEMFPIIG QYGDTLVKNL RREEEKGKPV NMKEILGAYS 

       190        200        210        220        230        240 
MDVITGTSFG VNVDSLNNPE DPFVQKARKI LKFNFFDPFI LSIILFPFLT TIYDLLRFSI 

       250        260        270        280        290        300 
FPRQSTNFFK KFITTMKKNR LHSNQKTRMD FFQLMMNTQN SKGKESQKAL SDLEMAAQAI 

       310        320        330        340        350        360 
IFIFAGYEST STSICLVLYE LATHPDVQKK LHDEIDSALP NKAPVTYDVL MGMEYLDMVI 

       370        380        390        400        410        420 
NEGLRLYPIA NRLERISKKA VEINGLFIPK GITVMVPTYP LHRDPEYWPE PEEFRPERFS 

       430        440        450        460        470        480 
KENKGSIDPY VYMPFGNGPR NCIGMRFALL SMKLAVVSVL QNFTLQTCEQ TENHLKFARQ 

       490        500 
IILQPENPII LKIISRDKPI TGA

« Hide

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References

[1]"Cloning, expression and regulation of lithocholic acid 6beta-hydroxylase."
Teixeira J., Gil G.
J. Biol. Chem. 266:21030-21036(1991) [PubMed: 1840595] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A STAT factor mediates the sexually dimorphic regulation of hepatic cytochrome P450 3A10/lithocholic acid 6 beta-hydroxylase gene expression by growth hormone."
Subramanian A., Teixeira J., Wang J., Gil G.
Mol. Cell. Biol. 15:4672-4682(1995) [PubMed: 7651384] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23.
[3]"The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation."
Chang T.K.H., Teixeira J., Gil G., Waxman D.J.
Biochem. J. 291:429-433(1993) [PubMed: 8484723] [Abstract]
Cited for: CHARACTERIZATION.

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Cross-references

Sequence databases

M73992 mRNA. No translation available.
S79317 Genomic DNA. Translation: AAB35091.1.
PIRA40843.

3D structure databases

HSSPHSSP built from PDB template 1JPZ based on UniProtKB P14779.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ64148.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR008072. Cyt_P450_E_CYP3A.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01689. EP450IICYP3A.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomQ64148.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameCP3AA_MESAU
AccessionPrimary (citable) accession number: Q64148
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: September 2, 2008
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents