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Reviewed, UniProtKB/Swiss-Prot Q26377 (CORZ_DROME)

Last modified November 4, 2008. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Pro-corazonin
      Short name=Crz
      Short name=Dm-Crz
Cleaved into the following 2 chains:
    1- Recommended name:
            Corazonin
    2- Recommended name:
            Corazonin precursor-related peptide
                Short name=CPRP
        Alternative name(s):
            Crz-associated peptide
Gene names
Name: Crz
ORF Names: CG3302
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat. Clock (Clk) and cycle (cyc) proteins negatively regulate Crz transcription in a cell-specific manner.

Subcellular location

Corazonin: Secreted.

Corazonin precursor-related peptide: SecretedBy similarity.

Tissue specificity

From late embryo to larva, expression is consistently detected in three neuronal groups: dorso-lateral neurons (DL), dorso-medial neurons (DM), and neurons in the ventral nerve cord (vCrz). Both the vCrz and DM groups die via programmed cell death during metamorphosis, whereas the DL neurons persist to adulthood. In adults, expression is seen in a cluster of six to eight neurons per lobe in the pars lateralis (DLP), in numerous neuronal cells in the optic lobes, and in a novel group of four abdominal ganglionic neurons present only in males (ms-aCrz). Projections of the ms-aCrz neurons terminate within the ventral nerve cord, implying a role as interneurons. Terminals of the DLP neurons are found in the retrocerebral complex that produces juvenile hormone and adipokinetic hormone, located in the vicinity of terminals emanating from PDF-containing pacemaking neurons.

Sequence similarities

Belongs to the corazonin family.

Mass spectrometry

Molecular weight is 1369.63 Da from positions 20 - 30. Determined by MALDI. Ref.5

Sequence caution

The sequence AAB32283.1 differs from that shown. Reason: Erroneous gene model prediction.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 154135Pro-corazonin Potential
PRO_0000341610
Peptide20 – 3011Corazonin
PRO_0000000948
Peptide34 – 6734Corazonin precursor-related peptide
PRO_0000000949
Propeptide70 – 15485
PRO_0000000950

Amino acid modifications

Modified residue201Pyrrolidone carboxylic acid
Modified residue301Asparagine amide

Experimental info

Sequence conflict811L → Q in AAB32283. Ref.3

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Sequences

Sequence LengthMass (Da)Tools
Q26377-1 [UniParc].

Last modified January 10, 2003. Version 2.
Checksum: 06046282A1C61A2F

FASTA15417,154
        10         20         30         40         50         60 
MLRLLLLPLF LFTLSMCMGQ TFQYSRGWTN GKRSFNAASP LLANGHLHRA SELGLTDLYD 

        70         80         90        100        110        120 
LQDWSSDRRL ERCLSQLQRS LIARNCVPGS DFNANRVDPD PENSAHPRLS NSNGENVLYS 

       130        140        150 
SANIPNRHRQ SNELLEELSA AGGASAEPNV FGKH

« Hide

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References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[3]"Isolation and structure of the Drosophila corazonin gene."
Veenstra J.A.
Biochem. Biophys. Res. Commun. 204:292-296(1994) [PubMed: 7945373] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-82.
[4]"Peptidomics of the larval Drosophila melanogaster central nervous system."
Baggerman G., Cerstiaens A., De Loof A., Schoofs L.
J. Biol. Chem. 277:40368-40374(2002) [PubMed: 12171930] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-30, AMIDATION.
Tissue: Larva.
[5]"Peptidomics of CNS-associated neurohemal systems of adult Drosophila melanogaster: a mass spectrometric survey of peptides from individual flies."
Predel R., Wegener C., Russell W.K., Tichy S.E., Russell D.H., Nachman R.J.
J. Comp. Neurol. 474:379-392(2004) [PubMed: 15174081] [Abstract]
Cited for: MASS SPECTROMETRY.
Tissue: Cerebral ganglion and Corpora cardiaca.
[6]"Comparative analysis of Corazonin-encoding genes (Crz's) in Drosophila species and functional insights into Crz-expressing neurons."
Choi Y.J., Lee G., Hall J.C., Park J.H.
J. Comp. Neurol. 482:372-385(2005) [PubMed: 15669053] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
Tissue: Head.
[7]"Developmental regulation and functions of the expression of the neuropeptide corazonin in Drosophila melanogaster."
Lee G., Kim K.-M., Kikuno K., Wang Z., Choi Y.-J., Park J.H.
Cell Tissue Res. 331:659-673(2008) [PubMed: 18087727] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AE014297 Genomic DNA. Translation: AAF55046.1.
S74038 Genomic DNA. Translation: AAB32283.1. Sequence problems.
PIRJC2384.
RefSeqNP_524350.1.
UniGeneDm.2429

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblCG3302. Drosophila melanogaster. [Contig view]
GeneID41742.
KEGGdme:Dmel_CG3302.
NMPDRfig|7227.3.peg.12748.

Organism-specific databases

FlyBaseFBgn0013767. Crz.

Phylogenomic databases

HOGENOMQ26377.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-011577-MON.

Gene expression databases

GermOnlineCG3302. Drosophila melanogaster.

Family and domain databases

BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio825345.

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Entry information

Entry nameCORZ_DROME
AccessionPrimary (citable) accession number: Q26377
Secondary accession number(s): Q9VFK7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 10, 2003
Last modified: November 4, 2008
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents