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Reviewed, UniProtKB/Swiss-Prot Q26307 (ANA_DROME)

Last modified November 4, 2008. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein anachronism
Gene names
Name: ana
ORF Names: CG8084
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Negatively regulates proliferation of neuronal precursor cells, thereby controlling the timing of postembryonic neurogenesis.

Subcellular location

Secreted.

Tissue specificity

Synthesized in some glial cells and secreted.

Ontologies

Keywords

   Biological processDifferentiation
Neurogenesis
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CG14487Q9V8761EBI-145644,EBI-136574

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Potential
Chain34 – 474441Protein anachronism
PRO_0000020730

Regions

Compositional bias453 – 46210Poly-His

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation731N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation3421N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3881A → G in AAB27582. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q26307-1 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: FE8A43042BB595A1

FASTA47454,015
        10         20         30         40         50         60 
MASAMRGEKC ERSRIRELVL ILSLITMAGD SRATPFDPSF FIEGVQSEVV NPFNRTILNR 

        70         80         90        100        110        120 
FNLTEEQILS IQNRSNPNMR DDSAQSSNQQ YLQQVATQRL NDIFKRVQKA ISNEPNGSAS 

       130        140        150        160        170        180 
KEKAGFPICN AETTNPEDWS LGNNVTLQFA SSVFISNNDD RLSSALLRLY KTNPGQTREH 

       190        200        210        220        230        240 
NPGQASTQPI STENPGNTAP NCAEQPPVGP QIRVTVSIVH QQRKKQRKKR TCNTAMLSSS 

       250        260        270        280        290        300 
STGWVEIDVK CALAYWEQQH RQQLRQQQPL QPQLTASVVG ILMIEVHDDE ENLLRPGLYF 

       310        320        330        340        350        360 
APPTCDQADI AVPWSVYRTE PFKSHLASWT LPRKPRLDIF FNGSNSMKNS YNTPKSRAFI 

       370        380        390        400        410        420 
ESTTSNSPTI DNQLDESGEY ESQQRVHAPL VHHRRHHHNH QQPESESESA QLEAEIEAEE 

       430        440        450        460        470 
LMSSASNSEQ QMEPISNHHR HRTGHHHPHH QLHQHHHHHH RHTKHHRIPA HKQE 

« Hide

References

« Hide 'large scale' references
[1]"The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation."
Ebens A.J., Garren H., Cheyette B.N.R., Zipursky S.L.
Cell 74:15-27(1993) [PubMed: 7916657] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Eye imaginal disk.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.

Cross-references

Sequence databases

S63815 mRNA. Translation: AAB27582.1.
AE013599 Genomic DNA. Translation: AAF58998.1.
RefSeqNP_477038.1.
UniGeneDm.7490

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:21780N.
IntActQ26307.

Genome annotation databases

EnsemblCG8084. Drosophila melanogaster. [Contig view]
GeneID35913.
KEGGdme:Dmel_CG8084.
NMPDRfig|7227.3.peg.3990.

Organism-specific databases

FlyBaseFBgn0011746. ana.

Phylogenomic databases

HOGENOMQ26307.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-003547-MON.

Gene expression databases

ArrayExpressQ26307.
GermOnlineCG8084. Drosophila melanogaster.

Family and domain databases

BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio795791.

Entry information

Entry nameANA_DROME
AccessionPrimary (citable) accession number: Q26307
Secondary accession number(s): Q9V524
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 4, 2008
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents