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Reviewed, UniProtKB/Swiss-Prot Q24488 (ROR1_DROME)

Last modified November 4, 2008. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Tyrosine-protein kinase transmembrane receptor Ror
    EC=2.7.10.1
Alternative name(s):
    dRor
Gene names
Name: Ror
ORF Names: CG4926
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length685 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Tyrosine-protein kinase receptor that functions during early stages of neuronal development.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass type I membrane proteinPotential.

Tissue specificity

Expressed in neurons of the developing nervous system.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

Contains 1 FZ (frizzled) domain.

Contains 1 kringle domain.

Contains 1 protein kinase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 685661Tyrosine-protein kinase transmembrane receptor Ror
PRO_0000024462

Regions

Topological domain25 – 317293Extracellular Potential
Transmembrane318 – 33821 Potential
Topological domain339 – 685347Cytoplasmic Potential
Domain36 – 225190FZ
Domain236 – 31075Kringle
Domain410 – 677268Protein kinase
Nucleotide binding416 – 4249ATP By similarity

Sites

Active site5391Proton acceptor By similarity
Binding site4421ATP By similarity

Amino acid modifications

Modified residue1121Phosphothreonine
Modified residue1311Phosphoserine
Modified residue5651Phosphotyrosine; by autocatalysis By similarity
Modified residue5691Phosphotyrosine; by autocatalysis By similarity
Modified residue5701Phosphotyrosine; by autocatalysis By similarity
Glycosylation451N-linked (GlcNAc...) Potential
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1291N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Disulfide bond41 ↔ 106 By similarity
Disulfide bond49 ↔ 99 By similarity
Disulfide bond90 ↔ 192 By similarity
Disulfide bond180 ↔ 222 By similarity
Disulfide bond184 ↔ 213 By similarity
Disulfide bond237 ↔ 310 By similarity
Disulfide bond258 ↔ 292 By similarity
Disulfide bond280 ↔ 305 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q24488-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 526162D27D5FD7C7

FASTA68578,143
        10         20         30         40         50         60 
MNKYSAFIVC ISLVLLFTKK DVGSHNVDSR IYGFQQSSGI CHIYNGTICR DVLSNAHVFV 

        70         80         90        100        110        120 
SPNLTMNDLE ERLKAAYGVI KESKDMNANC RMYALPSLCF SSMPICRTPE RTNLLYFANV 

       130        140        150        160        170        180 
ATNAKQLKNV SIRRKRTKSK DIKNISIFKK KSTIYEDVFS TDISSKYPPT RESENLKRIC 

       190        200        210        220        230        240 
REECELLENE LCQKEYAIAK RHPVIGMVGV EDCQKLPQHK DCLSLGITIE VDKTENCYWE 

       250        260        270        280        290        300 
DGSTYRGVAN VSASGKPCLR WSWLMKEISD FPELIGQNYC RNPGSVENSP WCFVDSSRER 

       310        320        330        340        350        360 
IIELCDIPKC ADKIWIAIVG TTAAIILIFI IIFAIILFKR RTIMHYGMRN IHNINTPSAD 

       370        380        390        400        410        420 
KNIYGNSQLN NAQDAGRGNL GNLSDHVALN SKLIERNTLL RINHFTLQDV EFLEELGEGA 

       430        440        450        460        470        480 
FGKVYKGQLL QPNKTTITVA IKALKENASV KTQQDFKREI ELISDLKHQN IVCILGVVLN 

       490        500        510        520        530        540 
KEPYCMLFEY MANGDLHEFL ISNSPTEGKS LSQLEFLQIA LQISEGMQYL SAHHYVHRDL 

       550        560        570        580        590        600 
AARNCLVNEG LVVKISDFGL SRDIYSSDYY RVQSKSLLPV RWMPSESILY GKFTTESDVW 

       610        620        630        640        650        660 
SFGVVLWEIY SYGMQPYYGF SNQEVINLIR SRQLLSAPEN CPTAVYSLMI ECWHEQSVKR 

       670        680 
PTFTDISNRL KTWHEGHFKA SNPEM

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References

« Hide 'large scale' references
[1]"Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases."
Wilson C., Goberdhan D.C.I., Steller H.
Proc. Natl. Acad. Sci. U.S.A. 90:7109-7113(1993) [PubMed: 8394009] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Canton-S.
Tissue: Larval brain.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA."
Oates A.C., Wollberg P., Achen M.G., Wilks A.F.
Biochem. Biophys. Res. Commun. 249:660-667(1998) [PubMed: 9731193] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 545-597.
[5]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-112 AND SER-131, MASS SPECTROMETRY.
Tissue: Embryo.

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Cross-references

Sequence databases

L20297 mRNA. Translation: AAA28860.1.
AE014134 Genomic DNA. Translation: AAF52885.1.
AJ002908 Genomic DNA. Translation: CAA05743.1.
PIRA48289.
RefSeqNP_476962.1.
UniGeneDm.4808

3D structure databases

HSSPHSSP built from PDB template 1LUF based on UniProtKB Q62838.
ModBaseSearch...

Genome annotation databases

EnsemblCG4926. Drosophila melanogaster. [Contig view]
GeneID34367.
KEGGdme:Dmel_CG4926.
NMPDRfig|7227.3.peg.1747.

Organism-specific databases

FlyBaseFBgn0010407. Ror.

Phylogenomic databases

HOGENOMQ24488.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-008308-MON.

Gene expression databases

ArrayExpressQ24488.
GermOnlineCG4926. Drosophila melanogaster.

Family and domain databases

InterProIPR000024. Frizzled_Cys-rich.
IPR000001. Kringle.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_bd_CS.
IPR002011. Recept_tyr_kinase-II_CS.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
[Graphical view]
Gene3DG3DSA:2.40.20.10. Kringle. 1 hit.
PfamPF00051. Kringle. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00018. KRINGLE.
PR00109. TYRKINASE.
ProDomPD000395. Kringle. 1 hit.
PD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00130. KR. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS50038. FZ. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio788146.

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Entry information

Entry nameROR1_DROME
AccessionPrimary (citable) accession number: Q24488
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 1, 1996
Last modified: November 4, 2008
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents