Gp160-Dtrk precursor - Drosophila melanogaster (Fruit fly)

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Unreviewed, UniProtKB/TrEMBL Q24327 (Q24327_DROME)

Last modified July 22, 2008. Version 57. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
Gp160-Dtrk EMBL CAA45053.1

Gene names

Name:	otk FlyBase FBgn0004839
Synonyms:	Dtrk EMBL CAA45053.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome] EMBL CAA45053.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1033 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU004146V1

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain RuleBase RU003326V0 Spearmint SPM008266 Repeat Spearmint SPM013098 Signal Transmembrane Spearmint SPM013098
Molecular function	Receptor Spearmint SPM013098
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	axon guidance Inferred from genetic interaction. Source: FlyBase cell adhesion Ref.1 Inferred from direct assay. Source: FlyBase protein amino acid phosphorylation Non-traceable author statement. Source: FlyBase
Cellular component	plasma membrane Ref.1 Inferred from direct assay. Source: FlyBase
Molecular function	cell adhesion molecule binding Ref.1 Inferred from direct assay. Source: FlyBase protein tyrosine kinase activity Non-traceable author statement. Source: FlyBase receptor activity Ref.1 Inferred from direct assay. Source: FlyBase semaphorin receptor binding Traceable author statement. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Signal peptide

23

Potential EMBL CAA45053.1

Chain

1010

gp160-Dtrk EMBL CAA45053.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q24327-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D282EFCB28ACA8D0
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1,033

114,368

        10         20         30         40         50         60 
MTARMISICG LVMALMMASV LASSSRFQRV PQSQSVVENE SVKFECESTD SYSELHYDWL 

        70         80         90        100        110        120 
HNGHRIAYDK RVHQIGSNLH IEAVRRTEDV GNYVCIATNL ASGAREASPP AKLSVIYLES 

       130        140        150        160        170        180 
ASVQLLGSNR NELLLKCHVE GASGDLEPLE IEWYRNSEKL STWKNVQLDQ HRLIIRQPGS 

       190        200        210        220        230        240 
EDDGLYRCTA SNAAGRVMSK QGYVYQSSVK CLPRLPRRKN QKMMESWDKQ TFLCRGKRGG 

       250        260        270        280        290        300 
AAGLEALPAA PEDLRIVQGP IGQSIIKEGE HTALTCLYEL PDELKNQRIQ LRWRKDGKLL 

       310        320        330        340        350        360 
RQVELGGSAP FPGHSFDSGK DALLREDARL VLHKQNGTLS FASIIASDAG QYQCQLQLEA 

       370        380        390        400        410        420 
HAPINSSPGI LEVIEQLKFV PQPTSKNLEL DAVVAKVHCK AQGTPTPQVQ WVRDGENTTL 

       430        440        450        460        470        480 
PDHVEVDANG TLIFRNVNSE HRGNYTCLAT NSQGQINATV AINVVVTPKF SVPPVGPIET 

       490        500        510        520        530        540 
SEQGTVVMHC QAIGDPKPTI QWDKDLKYLS ENNTDRERFR FLENGTLEIR NVQVEDEGSY 

       550        560        570        580        590        600 
GCTIGNSAGL KREDVQLVVK TTGDGFAPEE SGGDGFLVTR AVLITMTVAL AYIVLVVGLM 

       610        620        630        640        650        660 
LWCRYRRQAR KARLNDLSTK EAGGDQPDIA GNGKGSEQEP CLSKQHNGHS KSRSKSSGDA 

       670        680        690        700        710        720 
QKSDDTACSQ QSRASKKSAH IYEQLALPRS GLSELIQIGR GEFGDVFVGK LKATLVTSPS 

       730        740        750        760        770        780 
DKDADTEKQH SNSENGSGGS GSGSTTLSTL NEKRRSKTSM DDIEEIKEEE QEQHNQSGLE 

       790        800        810        820        830        840 
QLVLVKALNK VKDEQACQEF RRQLDLLRAI SHKGVVRLFG LCREKDPHYM VLEYTDWGDL 

       850        860        870        880        890        900 
KQFLLATAGK VNTATAGSSS PPPLTTSQVL AVAYQIARGM DAIYRARFTH RDLATRNCVI 

       910        920        930        940        950        960 
SSEFIVKVSY PALCKDKYSR EYHKHRNTLL PIRWLAPECI QEDEYTTKSD IFAYGVVVWE 

       970        980        990       1000       1010       1020 
LFNQATKLPH EELTNEQVVQ RSQAGSLEWS VAEATPDSLR EILLSCWVSN PKERPSFSQL 

      1030 
GAALSKAMQS AEK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule." Pulido D., Campuzano S., Koda T., Modolell J., Barbacid M. EMBO J. 11:391-404(1992) [PubMed: 1371458] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Canton S EMBL CAA45053.1.
[2]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
	X63453 mRNA. Translation: CAA45053.1.
PIR	S19247.
3D structure databases
HSSP	HSSP built from PDB template 1EVT based on UniProtKB P11362.
ModBase	Search...
Genome annotation databases
Ensembl	CG8967. Drosophila melanogaster. [Contig view]
Organism-specific databases
FlyBase	FBgn0004839. otk.
Phylogenomic databases
HOGENOM	Q24327.
Gene expression databases
ArrayExpress	Q24327.
Family and domain databases
InterPro	IPR013151. Ig. IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR000719. Prot_kinase_core. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 4 hits.
Pfam	PF07679. I-set. 2 hits. PF00047. ig. 2 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00409. IG. 2 hits. SM00408. IGc2. 3 hits. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 5 hits. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. Uncertain. [Graphical view]

Entry information

Entry name

Q24327_DROME

Accession

Primary (citable) accession number: Q24327

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	July 22, 2008
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information