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Reviewed, UniProtKB/Swiss-Prot Q24324 (DSOR1_DROME)

Last modified November 4, 2008. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Dual specificity mitogen-activated protein kinase kinase dSOR1
      Short name=Downstream of RAF
      Short name=MAPKK
    EC=2.7.12.2
Gene names
Name: Dsor1
ORF Names: CG15793
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Developmental stage

Expressed both maternally and zygotically.

Post-translational modification

Phosphorylation on Ser/Thr by MAP kinase kinase kinases regulates positively the kinase activity By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAA02925.1 differs from that shown. Reason: Erroneous gene model prediction.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Dual specificity mitogen-activated protein kinase kinase dSOR1
PRO_0000085928

Regions

Domain87 – 364278Protein kinase
Nucleotide binding93 – 1019ATP By similarity

Sites

Active site2091Proton acceptor By similarity
Binding site1161ATP By similarity

Amino acid modifications

Modified residue2371Phosphoserine; by RAF By similarity
Modified residue2411Phosphoserine; by RAF By similarity

Natural variations

Natural variant3941S → L in strain: Reids2.

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Sequences

Sequence LengthMass (Da)Tools
Q24324-1 [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: 9245CED1DA750C33

FASTA39643,870
        10         20         30         40         50         60 
MSKNKLNLVL PPVNTEATVA AATVAPTPPF KTPSGTDTHS LLGKPKTSID ALTETLEGLD 

        70         80         90        100        110        120 
MGDTERKRIK MFLSQKEKIG ELSDEDLEKL GELGSGNGGV VMKVRHTHTH LIMARKLIHL 

       130        140        150        160        170        180 
EVKPAIKKQI LRELKVLHEC NFPHIVGFYG AFYSDGEISI CMEYMDGGSL DLILKRAGRI 

       190        200        210        220        230        240 
PESILGRITL AVLKGLSYLR DNHAIIHRDV KPSNILVNSS GEIKICDFGV SGQLIDSMAN 

       250        260        270        280        290        300 
SFVGTRSYMS PERLQGTHYS VQSDIWSLGL SLVEMAIGMY PIPPPNTATL ESIFADNAEE 

       310        320        330        340        350        360 
SGQPTDEPRA MAIFELLDYI VNEPPPKLEH KIFSTEFKDF VDICLKKQPD ERADLKTLLS 

       370        380        390 
HPWIRKAELE EVDISGWVCK TMDLPPSTPK RNTSPN

« Hide

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References

« Hide 'large scale' references
[1]"A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila."
Tsuda L., Inoue Y.H., Yoo M.-A., Mizuno M., Hata M., Lim Y.-M., Adachi-Yamada T., Ryo H., Masamune Y., Nishida Y.
Cell 72:407-414(1993) [PubMed: 8381718] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DEVELOPMENTAL STAGE.
[2]"Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in Drosophila."
Riley R.M., Jin W., Gibson G.
Mol. Ecol. 12:1315-1323(2003) [PubMed: 12694293] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 5-17-88#b1, 5-17-88a#4, 5-17-88a#6, 5-17-88b#1, 5-17-88b#5, 7-21-88#b2, 7-21-88b#1, 7-21-88b#2, 7-21-88b#4, AA1, AA16, AA18, AA20, AA3, CA2, M2, PYR2, Reids2 and wild5b.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[5]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.

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Cross-references

Sequence databases

D13782 Genomic DNA. Translation: BAA02925.1. Sequence problems.
AY135075 Genomic DNA. Translation: AAN17587.1.
AY135076 Genomic DNA. Translation: AAN17588.1.
AY135077 Genomic DNA. Translation: AAN17589.1.
AY135078 Genomic DNA. Translation: AAN17590.1.
AY135079 Genomic DNA. Translation: AAN17591.1.
AY135080 Genomic DNA. Translation: AAN17592.1.
AY135081 Genomic DNA. Translation: AAN17593.1.
AY135082 Genomic DNA. Translation: AAN17594.1.
AY135083 Genomic DNA. Translation: AAN17595.1.
AY135084 Genomic DNA. Translation: AAN17596.1.
AY135085 Genomic DNA. Translation: AAN17597.1.
AY135086 Genomic DNA. Translation: AAN17598.1.
AY135087 Genomic DNA. Translation: AAN17599.1.
AY135088 Genomic DNA. Translation: AAN17600.1.
AY135089 Genomic DNA. Translation: AAN17601.1.
AY135090 Genomic DNA. Translation: AAN17602.1.
AY135091 Genomic DNA. Translation: AAN17603.1.
AY135092 Genomic DNA. Translation: AAN17604.1.
AY135093 Genomic DNA. Translation: AAN17605.1.
AE014298 Genomic DNA. Translation: AAF46475.1.
AY058692 mRNA. Translation: AAL13921.1.
PIRA45176.
RefSeqNP_511098.1.
UniGeneDm.2620

3D structure databases

HSSPHSSP built from PDB template 1F3M based on UniProtKB Q13153.
SMRQ24324. Positions 75-384.
ModBaseSearch...

Protein-protein interaction databases

IntActQ24324.

Genome annotation databases

EnsemblCG15793. Drosophila melanogaster. [Contig view]
GeneID31872.
KEGGdme:Dmel_CG15793.
NMPDRfig|7227.3.peg.17128.

Organism-specific databases

FlyBaseFBgn0010269. Dsor1.

Phylogenomic databases

HOGENOMQ24324.

Gene expression databases

ArrayExpressQ24324.
GermOnlineCG15793. Drosophila melanogaster.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_bd_CS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio775740.

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Entry information

Entry nameDSOR1_DROME
AccessionPrimary (citable) accession number: Q24324
Secondary accession number(s): Q8ISE0, Q9W360
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: August 16, 2005
Last modified: November 4, 2008
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents