Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q24247 (ITA1_DROME)

Last modified September 23, 2008. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Integrin alpha-PS1
Alternative name(s):
    Position-specific antigen 1 alpha subunit
    Protein multiple edematous wings
Cleaved into the following 2 chains:
    1- Recommended name:
            Integrin alpha-PS1 heavy chain
    2- Recommended name:
            Integrin alpha-PS1 light chain
Gene names
Name: mew
ORF Names: CG1771
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Hide | Top

Protein attributes

Sequence length1146 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Integrin alpha-PS1/beta-PS is a receptor for laminin.

Subunit structure

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-PS1 associates with beta-PS.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the integrin alpha chain family.

Contains 7 FG-GAP repeats.

Hide | Top

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform B (identifier: Q24247-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform A (identifier: Q24247-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
Notes: No experimental confirmation available.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 11461116Integrin alpha-PS1
Chain31 – ?960930Integrin alpha-PS1 heavy chain Potential
Chain?961 – 1146186Integrin alpha-PS1 light chain Potential

Regions

Topological domain31 – 10851055Extracellular Potential
Transmembrane1086 – 110621 Potential
Topological domain1107 – 114640Cytoplasmic Potential
Repeat49 – 11668FG-GAP 1
Repeat117 – ?FG-GAP 2
Repeat199 – 26365FG-GAP 3
Repeat264 – 31754FG-GAP 4
Repeat318 – 37457FG-GAP 5
Repeat377 – 43458FG-GAP 6
Repeat443 – 49755FG-GAP 7

Amino acid modifications

Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation1471N-linked (GlcNAc...) Potential
Glycosylation4701N-linked (GlcNAc...) Potential
Glycosylation5111N-linked (GlcNAc...) Potential
Glycosylation6571N-linked (GlcNAc...)
Glycosylation6801N-linked (GlcNAc...) Potential
Glycosylation7111N-linked (GlcNAc...) Potential
Glycosylation7181N-linked (GlcNAc...) Potential
Glycosylation7611N-linked (GlcNAc...) Potential
Glycosylation9281N-linked (GlcNAc...) Potential
Glycosylation10271N-linked (GlcNAc...)

Natural variations

Alternative sequence1 – 9797Missing in isoform A.

Experimental info

Sequence conflict730 – 7312ML → IV in CAA52155. Ref.1
Sequence conflict8151D → E in CAA52155. Ref.1

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Isoform B [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: E8AB75BC8DE6854E

FASTA1,146127,973
        10         20         30         40         50         60 
MLELPFTTIR PNCRLRQNLG ILIILQCVLT CYNFNLEQRL PIVKYGHPHS HFGYSVATHT 

        70         80         90        100        110        120 
IGEANGPNKT NCVLVGAPLD QNRQPNTTHS GALWRCPMTQ RFDDCEQVIT DGRRNFDSEI 

       130        140        150        160        170        180 
LSPPGNDEIK EDQWMGVTVR SNPLQANGSG GKVIVCAHRY MYIVRENRYG QGLCYLLTND 

       190        200        210        220        230        240 
LQFEEVHEPC KGRPVQRQHE DYGLCQAGTS AALLDDDTMV LGSPGPYTWR GSIWVTQVGG 

       250        260        270        280        290        300 
EYLQRDKTTY YSDHSDLNSP VDKYSYLGMS VTGGRFFGHM SYAAGAPRSE GHGQVVIFDK 

       310        320        330        340        350        360 
STDNPIPVHS ILDGEQFGSS FGYELATADI NGDHRPDLIV AAPLYFTKTE GGAVYVYQNI 

       370        380        390        400        410        420 
QDTLPMKYTL KLTGPLESRF GLALANIGDL NKDNCEDLAV GAPYEGNGVV YIYLGSSQGL 

       430        440        450        460        470        480 
NSKPAQKIQA SELGGTIPNG QPIRTFGISI SGNTDLDDNS YPDVVIGAFN SSAAVILLAR 

       490        500        510        520        530        540 
PIISIQTSVQ RKELHNMDPN TPGCLDDPAS NLTCFTFRAC CSIEPYDEKN KELRLAYSVE 

       550        560        570        580        590        600 
AETFDHLKKF SRVFFFDREN KRTNVLSRVV RVHTNGRTEC QAVTGYIKAN TRDIQTPVRF 

       610        620        630        640        650        660 
RLKYSLVEPP LADSALVRLN PILDQTQAHV DFEGTFQKDC GDDDLCESNL IIRVEPNITE 

       670        680        690        700        710        720 
SSGNEYTLIL DETELEVRIN VSNLADSAYE AQLFIAHQAG VSYVATKKPT NATCNSYNTT 

       730        740        750        760        770        780 
LVACSLGNPM LRDTTTFVTI RFQPKGLEPS EKIMLFHIFA NTTSKLVGPE RPERDLRVNV 

       790        800        810        820        830        840 
VRRAKLNFRG WAIPEQSFYS GSSVANSVAN TAATDIEGHG PMGMDDVGSQ VHHMFTIFNE 

       850        860        870        880        890        900 
GPSTAPKVQM VIHWPYSLYS DPQSGRPVQY LLYLEQVPTV EVSQGECHVA KEYVNPLNLA 

       910        920        930        940        950        960 
SGSRENPAYL SAPAQMRMFP SQSRHSFNKS LIHSQRSYYS SSHRDDHSDD TQSNRNRVRR 

       970        980        990       1000       1010       1020 
SFLERVTRLE RLMYDPESSN AANGKKQDIV ELDCNKGATN CVRIECDILN MPALSEAQVV 

      1030       1040       1050       1060       1070       1080 
VKARLWNSTL VSEYPRVERV RIFSTATAQI PESYGVEVMD HNNIEVETRA YPELRNQQRD 

      1090       1100       1110       1120       1130       1140 
TSIPWLIIIL GIVGGLLLLA LVTYVLWKVG FFKRIRPTDP TLSGNLEKMN EEKPFLAPSK 


NTHHVF

« Hide

Isoform A [UniParc].

Checksum: 49304E861063716F
Show »

1,049117,097

Hide | Top

References

« Hide 'large scale' references
[1]"Cloning and characterization of alpha PS1, a novel Drosophila melanogaster integrin."
Wehrli M., Diantonio A., Fearnley I.M., Smith R.J., Wilcox M.
Mech. Dev. 43:21-36(1993) [PubMed: 8240969] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), PARTIAL PROTEIN SEQUENCE.
Strain: Oregon-R.
Tissue: Embryo and Larva.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Strain: Berkeley.
Tissue: Head.
[5]"Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster."
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L., Panin V.
Glycobiology 17:1388-1403(2007) [PubMed: 17893096] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-657 AND ASN-1027, MASS SPECTROMETRY.
Tissue: Head.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

X73975 mRNA. Translation: CAA52155.1.
AE014298 Genomic DNA. Translation: AAF48242.2.
AE014298 Genomic DNA. Translation: AAN09652.1.
AY075338 mRNA. Translation: AAL68203.1.
PIRS40311.
RefSeqNP_511145.2.
NP_727679.1.
UniGeneDm.152

3D structure databases

HSSPHSSP built from PDB template 1A8X based on UniProtKB P11215.
ModBaseSearch...

Genome annotation databases

EnsemblCG1771. Drosophila melanogaster. [Contig view]
GeneID32275.
KEGGdme:Dmel_CG1771.

Organism-specific databases

FlyBaseFBgn0004456. mew.

Phylogenomic databases

HOGENOMQ24247.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-001717-MON.

Gene expression databases

ArrayExpressQ24247.
GermOnlineCG1771. Drosophila melanogaster.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR013513. Integrin_alpha_C.
[Graphical view]
PfamPF01839. FG-GAP. 2 hits.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
[Graphical view]
PRINTSPR01185. INTEGRINA.
SMARTSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEPS00242. INTEGRIN_ALPHA. 1 hit.
[Graphical view]
ProDomQ24247.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

Hide | Top

Entry information

Entry nameITA1_DROME
AccessionPrimary (citable) accession number: Q24247
Secondary accession number(s): Q8SY51, Q9VYF6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 21, 2001
Last modified: September 23, 2008
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Hide | Top

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents