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Reviewed, UniProtKB/Swiss-Prot Q24152 (CKS1_DROME)

Last modified November 4, 2008. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cyclin-dependent kinases regulatory subunit
Gene names
Name: Cks30A
Synonyms: CDI2, Cks, Cks1
ORF Names: CG3738
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length74 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds to the catalytic subunit of the cyclin dependent kinases (Cdc2 and Cdc2c) and is essential for their biological function.

Subunit structure

Forms an homohexamer that can probably bind six kinase subunits By similarity.

Sequence similarities

Belongs to the CKS family.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

LQ9V7251EBI-136853,EBI-138419

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7474Cyclin-dependent kinases regulatory subunit
PRO_0000206242

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Sequences

Sequence LengthMass (Da)Tools
Q24152-1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 1AAF5486960FE8AD

FASTA749,122
        10         20         30         40         50         60 
MSKDIYYSDK YYDEQFEYRH VVLPKELVKM VPKTHLMTEA EWRSIGVQQS RGWIHYMIHK 

        70 
PEPHILLFRR PKTD

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References

« Hide 'large scale' references
[1]"Interaction mating reveals binary and ternary connections between Drosophila cell cycle regulators."
Finley R.L. Jr., Brent R.
Proc. Natl. Acad. Sci. U.S.A. 91:12980-12984(1994) [PubMed: 7809159] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U40077 mRNA. Translation: AAB02189.1.
AE014134 Genomic DNA. Translation: AAF52763.1.
AY061285 mRNA. Translation: AAL28833.1.
RefSeqNP_476947.1.
UniGeneDm.2110

3D structure databases

HSSPHSSP built from PDB template 1CKS based on UniProtKB P33552.
SMRQ24152. Positions 5-71.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:17394N.
IntActQ24152.

Genome annotation databases

EnsemblCG3738. Drosophila melanogaster. [Contig view]
GeneID34250.
KEGGdme:Dmel_CG3738.
NMPDRfig|7227.3.peg.1576.

Organism-specific databases

FlyBaseFBgn0010314. Cks30A.

Phylogenomic databases

HOGENOMQ24152.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-008146-MON.

Gene expression databases

GermOnlineCG3738. Drosophila melanogaster.

Family and domain databases

InterProIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
Gene3DG3DSA:3.30.170.10. Cyclin-dep_kinase_reg-sub. 1 hit.
PfamPF01111. CKS. 1 hit.
[Graphical view]
PRINTSPR00296. CYCLINKINASE.
ProDomPD005152. Cyc_dep_kin_rsub. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00944. CKS_1. 1 hit.
PS00945. CKS_2. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio787572.

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Entry information

Entry nameCKS1_DROME
AccessionPrimary (citable) accession number: Q24152
Secondary accession number(s): Q9VLD0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 4, 2008
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents