LATS - Drosophila melanogaster (Fruit fly)

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Unreviewed, UniProtKB/TrEMBL Q24096 (Q24096_DROME)

Last modified October 14, 2008. Version 65. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein names

Submitted name:
LATS EMBL AAA70336.1

Gene names

Name:	wts EMBL AAA70336.1
ORF Names:	CG12072 FlyBase FBgn0011739

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome] EMBL AAA70336.1

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1099 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein. Spearmint SPM000961
Sequence similarities	Belongs to the protein kinase superfamily. RuleBase RU000305V3

Ontologies

Keywords
Ligand	ATP-binding Spearmint SPM000961 RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Spearmint SPM000961 RuleBase RU000305V3 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis Inferred from genetic interaction. Source: FlyBase R8 cell fate specification Inferred from mutant phenotype. Source: FlyBase negative regulation of cell proliferation Inferred from mutant phenotype. Source: FlyBase negative regulation of organ growth Traceable author statement. Source: FlyBase protein amino acid phosphorylation Non-traceable author statement. Source: FlyBase regulation of cell shape Inferred from mutant phenotype. Source: FlyBase regulation of imaginal disc growth Traceable author statement. Source: FlyBase response to ionizing radiation Inferred from mutant phenotype. Source: FlyBase
Molecular function	protein binding Traceable author statement. Source: FlyBase protein serine/threonine kinase activity Non-traceable author statement. Source: FlyBase specific transcriptional repressor activity Inferred from mutant phenotype. Source: FlyBase
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q24096-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A21FB0B0964B1689
Show »

1,099

121,719

        10         20         30         40         50         60 
MHPAGEKRGG RPNDKYTAEA LESIKQDLTR FEVQNNHRNN QNYTPLRYTA TNGRNDALTP 

        70         80         90        100        110        120 
DYHHAKQPME PPPSASPAPD VVIPPPPAIV GQPGAGSISV SGVGVGVVGV ANGRVPKMMT 

       130        140        150        160        170        180 
ALMPNKLIRK PSIERDTASS HYLRCSPALD SGAGSSRSDS PHSHHTHQPS SRTVGNPGGN 

       190        200        210        220        230        240 
GGFSPSPSGF SEVAPPAPPP RNPTASSAAT PPPPVPPTSQ AYVKRRSPAL NNRPPAIAPP 

       250        260        270        280        290        300 
TQRGNSPVIT QNGLKNPQQQ LTQQLKSLNL YPGGGSGAVV EPPPPYLIQG GAGGAAPPPP 

       310        320        330        340        350        360 
PPSYTASMQS RQSPTQSQQS DYRKSPSSGI YSATSAGSPS PITVSLPPAP LAKPQPRVYQ 

       370        380        390        400        410        420 
ARSQQPIIMQ SVKSTQVQKP VLQTAVARQS PSSASASNSP VHVLAAPPSY PQKSAAVVQQ 

       430        440        450        460        470        480 
QQQAAAAAHQ QQHQHQQSKP PTPTTPPLVG LNSKPNCLEP PSYAKSMQAK AATVVQQQQQ 

       490        500        510        520        530        540 
QQQQQQVQQQ QVQQQQQQQQ QQLQALRVLQ AQAQRERDQR ERERDQQKLA NGNPGRQMLP 

       550        560        570        580        590        600 
PPPYQSNNNN NSEIKPPSCN NNNIQISNSN LATTPPIPPA KYNNNSSNTG ANSSGGSNGS 

       610        620        630        640        650        660 
TGTTASSSTS CKKIKHASPI PERKKISKEK EEERKEFRIR QYSPQAFKFF MEQHIENVIK 

       670        680        690        700        710        720 
SYRQRTYRKN QLEKEMHKVG LPDQTQIEMR KMLNQKESNY IRLKRAKMDK SMFVKLKPIG 

       730        740        750        760        770        780 
VGAFGEVTLV SKIDTSNHLY AMKTLRKADV LKRNQVAHVK AERDILAEAD NNWVVKLYYS 

       790        800        810        820        830        840 
FQDKDNLYFV MDYIPGGDLM SLLIKLGIFE EELARFYIAE VTCAVDSVHK MGFIHRDIKP 

       850        860        870        880        890        900 
DNILIDRDGH IKLTDFGLCT GFRWTHNSKY YQENGNHSRQ DSMEPWEEYS ENGPKPTVLE 

       910        920        930        940        950        960 
RRRMRDHQRV LAHSLVGTPN YIAPEVLERS GYTQLCDYWS VGVILYEMLV GQPPFLANSP 

       970        980        990       1000       1010       1020 
LETQQKVINW EKTLHIPPQA ELSREATDLI RRLCASADKR LGKSVDEVKS HDFFKGIDFA 

      1030       1040       1050       1060       1070       1080 
DMRKQKAPYI PEIKHPTDTS NFDPVDPEKL RSNDSTMSSG DDVDQNDRTF HGFFEFTFRR 

      1090 
FFDDKQPPDM TDDQAPVYV

References

[1]	"Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase." Xu T., Wang W., Zhang S., Stewart R.A., Yu W. Development 121:1053-1063(1995) [PubMed: 7743921] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
	U29608 mRNA. Translation: AAA70336.1.
3D structure databases
HSSP	HSSP built from PDB template 1H1W based on UniProtKB O15530.
ModBase	Search...
Organism-specific databases
FlyBase	FBgn0011739. wts.
Gene expression databases
ArrayExpress	Q24096.
Family and domain databases
InterPro	IPR000961. Pkinase_C. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. Uncertain. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]

Entry information

Entry name

Q24096_DROME

Accession

Primary (citable) accession number: Q24096

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	October 14, 2008
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information