Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot Q24040 (BGB_DROME)

Last modified November 4, 2008. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Protein big brother
Gene names
Name: Bgb
ORF Names: CG7959
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Hide | Top

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Regulates the DNA-binding properties of Runt.

Subcellular location

NucleusPotential.

Sequence similarities

Belongs to the CBF-beta family.

Hide | Top

Ontologies

Keywords

   Cellular componentNucleus
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processregulation of transcription from RNA polymerase II promoter

Traceable author statement. Source: FlyBase

   Cellular componentnucleus Ref.1

Inferred from direct assay. Source: FlyBase

   Molecular functionprotein heterodimerization activity

Traceable author statement. Source: FlyBase

transcription coactivator activity Ref.1

Inferred from direct assay. Source: FlyBase

Complete GO annotation...

Hide | Top

Binary interactions

With

Entry

#Exp.

IntAct

Notes

runP228141EBI-136112,EBI-868309

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Protein big brother
PRO_0000064920

Experimental info

Sequence conflict81A → S Ref.1
Sequence conflict241P → K Ref.1
Sequence conflict1411E → D in AAB03676. Ref.1

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q24040-1 [UniParc].

Last modified January 16, 2004. Version 3.
Checksum: 6FC6156136B362AA

FASTA21325,177
        10         20         30         40         50         60 
MMNEAALANM IPYDTIGLYE QPKPRFIFKM PRVVPDQKSK FESDELFRRL SRESEVRYTG 

        70         80         90        100        110        120 
YRERSIEERQ VRFMNGCREG HTEASFVASG TNLQLVFNAN QNPYLHDKEC DFDKEHGKVH 

       130        140        150        160        170        180 
IKSYFIMNGV CVRFRGWIDL ERLDGVGCLE YDERRAMHED AILRDQIDRY NQRLREFEDT 

       190        200        210 
KRAYRDNRQD EMEAVRRGVA SGGIGVGASM WRR

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate the DNA-binding properties of Runt."
Golling G., Li L., Pepling M., Stebbins M., Gergen J.P.
Mol. Cell. Biol. 16:932-942(1996) [PubMed: 8622696] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.

Hide | Top

Cross-references

Sequence databases

U22177 mRNA. Translation: AAB03676.1. Different initiation.
AE014296 Genomic DNA. Translation: AAF47533.3.
AY058784 mRNA. Translation: AAL14013.1.
RefSeqNP_477065.3.
UniGeneDm.4101

3D structure databases

HSSPHSSP built from PDB template 1E50 based on UniProtKB Q13951.
ModBaseSearch...

Protein-protein interaction databases

IntActQ24040.

Genome annotation databases

EnsemblCG7959. Drosophila melanogaster. [Contig view]
GeneID38198.
KEGGdme:Dmel_CG7959.
NMPDRfig|7227.3.peg.7612.

Organism-specific databases

FlyBaseFBgn0013753. Bgb.

Phylogenomic databases

HOGENOMQ24040.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-014697-MON.

Gene expression databases

ArrayExpressQ24040.
GermOnlineCG7959. Drosophila melanogaster.

Family and domain databases

InterProIPR003417. CBF_beta.
[Graphical view]
Gene3DG3DSA:2.40.250.10. CBF_beta. 1 hit.
PANTHERPTHR10276. CBF_beta. 1 hit.
PfamPF02312. CBF_beta. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio807472.

Hide | Top

Entry information

Entry nameBGB_DROME
AccessionPrimary (citable) accession number: Q24040
Secondary accession number(s): Q95TG4, Q9W0B9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 16, 2004
Last modified: November 4, 2008
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Hide | Top

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents