Reviewed,
UniProtKB/Swiss-Prot Q12766 (SMF_HUMAN)
Last modified
November 4, 2008.
Version 52.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Protein SMF | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1538 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | NucleusPotential. |
| Sequence similarities | Contains 1 HMG box DNA-binding domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Nucleus |
| Ligand | DNA-binding |
Gene Ontology (GO) | |
| Cellular component | nucleolus Inferred from direct assay. Source: HPA |
| Molecular function | kinase activity Ref.4 Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1538 | 1538 | Protein SMF | PRO_0000048806 | |||||
Regions | |||||||||
| DNA binding | 288 – 356 | 69 | HMG box | ||||||
| Compositional bias | 62 – 239 | 178 | Arg-rich | ||||||
| Compositional bias | 276 – 282 | 7 | Poly-Lys | ||||||
| Compositional bias | 518 – 524 | 7 | Poly-Ser | ||||||
| Compositional bias | 1523 – 1532 | 10 | Poly-Glu | ||||||
Experimental info | |||||||||
| Sequence conflict | 734 | 1 | A → V in AAH51025. Ref.2 | ||||||
| Sequence conflict | 734 | 1 | A → V in BAA12107. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.  Rubin E.M.Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-1538. Tissue: Brain. |
| [3] | "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Ishikawa K., Tanaka A., Nomura N. DNA Res. 3:17-24(1996) [PubMed: 8724849] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 104-1538. Tissue: Bone marrow. |
| [4] | "Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes." Andre C., Hampe A., Lachaume P., Martin E., Wang X.P., Manus V., Hu W.X., Galibert F. Genomics 39:216-226(1997) [PubMed: 9027509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1161-1538. Tissue: Placenta. |
Cross-references
Sequence databases | |
|---|---|
| AC011406 Genomic DNA. No translation available. BC051025 mRNA. Translation: AAH51025.1. D83778 mRNA. Translation: BAA12107.1. U63963 Genomic DNA. Translation: AAB51697.1. | |
| UniGene | Hs.586219 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q12766. |
Genome annotation databases | |
| Ensembl | ENSG00000113716. Homo sapiens. [Contig view] |
Organism-specific databases | |
| HPA | HPA002354. HPA005967. |
| HUGE | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q12766. |
| HOVERGEN | Q12766. |
Gene expression databases | |
| GermOnline | ENSG00000113716. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000910. HMG_1/2_box. [Graphical view] |
| Gene3D | G3DSA:1.10.30.10. HMG-box. 1 hit. |
| Pfam | PF00505. HMG_box. 1 hit. [Graphical view] |
| SMART | SM00398. HMG. 1 hit. [Graphical view] |
| PROSITE | PS50118. HMG_BOX_2. 1 hit. [Graphical view] |
| BLOCKS | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | SMF_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q12766 Secondary accession number(s): Q86UG3, Q9UMF4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 5 Human chromosome 5: entries, gene names and cross-references to MIM |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |
