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Reviewed, UniProtKB/Swiss-Prot Q07540 (FRDA_YEAST)

Last modified September 23, 2008. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Frataxin homolog, mitochondrial
Cleaved into the following 1 chains:
    1- Recommended name:
            Frataxin homolog intermediate form
Gene names
Name: YFH1
Ordered Locus Names: YDL120W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length174 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Seems to be involved in the regulation of mitochondrial iron efflux.

Subunit structure

Interacts with ISU1.

Subcellular location

Mitochondrion matrix.

Post-translational modification

Processed in two steps by mitochondrial processing peptidase (MPP). MPP first cleaves the precursor to intermediate form and subsequently converts the intermediate to mature size protein.

Miscellaneous

Present with 1560 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the frataxin family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Transit peptide1 – 2121Mitochondrion Probable
Chain22 – 174153Frataxin homolog intermediate form
Chain52 – 174123Frataxin homolog, mitochondrial

Secondary structure

1 ........................ 174
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q07540-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AB1FF7478EF0E5D6

FASTA17419,490
        10         20         30         40         50         60 
MIKRSLASLV RVSSVMGRRY MIAAAGGERA RFCPAVTNKK NHTVNTFQKR FVESSTDGQV 

        70         80         90        100        110        120 
VPQEVLNLPL EKYHEEADDY LDHLLDSLEE LSEAHPDCIP DVELSHGVMT LEIPAFGTYV 

       130        140        150        160        170 
INKQPPNKQI WLASPLSGPN RFDLLNGEWV SLRNGTKLTD ILTEEVEKAI SKSQ

« Hide

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References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin."
Babcock M., de Silva D., Oaks R., Davis-Kaplan S., Jiralerspong S., Montermini L., Pandolfo M., Kaplan J.
Science 276:1709-1712(1997) [PubMed: 9180083] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"The yeast frataxin homologue mediates mitochondrial iron efflux. Evidence for a mitochondrial iron cycle."
Radisky D.C., Babcock M.C., Kaplan J.
J. Biol. Chem. 274:4497-4499(1999) [PubMed: 9988680] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Maturation of frataxin within mammalian and yeast mitochondria: one-step processing by matrix processing peptidase."
Gordon D.M., Shi Q., Dancis A., Pain D.
Hum. Mol. Genet. 8:2255-2262(1999) [PubMed: 10545606] [Abstract]
Cited for: PROCESSING.
[6]"Yeast and human frataxin are processed to mature form in two sequential steps by the mitochondrial processing peptidase."
Branda S.S., Cavadini P., Adamec J., Kalousek F., Taroni F., Isaya G.
J. Biol. Chem. 274:22763-22769(1999) [PubMed: 10428860] [Abstract]
Cited for: PROCESSING.
[7]"Saccharomyces cerevisiae ISU1 and ISU2: members of a well-conserved gene family for iron-sulfur cluster assembly."
Garland S.A., Hoff K., Vickery L.E., Culotta V.C.
J. Mol. Biol. 294:897-907(1999) [PubMed: 10588895] [Abstract]
Cited for: INTERACTION WITH ISU1.
[8]"An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1."
Gerber J., Muhlenhoff U., Lill R.
EMBO Rep. 4:906-911(2003) [PubMed: 12947415] [Abstract]
Cited for: INTERACTION WITH ISU1.
[9]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z74168 Genomic DNA. Translation: CAA98688.1.
AY558160 Genomic DNA. Translation: AAS56486.1.
PIRS67663.
RefSeqNP_010163.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2FQLX-ray3.01A52-174[»]
2GA5NMR-A52-174[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:7485N.

Genome annotation databases

EnsemblYDL120W. Saccharomyces cerevisiae. [Contig view]
GeneID851437.
GenomeReviewsGene locus YDL120W in contig Z71256_GR.
KEGGsce:YDL120W.
NMPDRfig|4932.3.peg.900.

Organism-specific databases

CYGDYDL120w.
SGDS000002278. YFH1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMQ07540.

Gene expression databases

GermOnlineYDL120W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR017789. Frataxin.
IPR002908. Frataxin_like.
IPR001794. Frataxin_sub.
[Graphical view]
Gene3DG3DSA:3.30.920.10. Frataxin_like. 1 hit.
PfamPF01491. Frataxin_Cyay. 1 hit.
[Graphical view]
PRINTSPR00904. FRATAXIN.
ProDomPD238818. Frataxin_like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR03421. FeS_CyaY. 1 hit.
PROSITEPS01344. FRATAXIN_1. 1 hit.
PS50810. FRATAXIN_2. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

LinkHubQ07540.
ProtoNetSearch...

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Entry information

Entry nameFRDA_YEAST
AccessionPrimary (citable) accession number: Q07540
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 23, 2008
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Recent format changes

Overview of recent format changes

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents