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Reviewed, UniProtKB/Swiss-Prot Q07217 (CP11A_ONCMY)

Last modified September 2, 2008. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 11A1, mitochondrial
    EC=1.14.15.6
Alternative name(s):
    CYPXIA1
    Cholesterol side-chain cleavage enzyme
    P450(SCC)
    Cholesterol desmolase
Gene names
Name: cyp11a1
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus

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Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. Increased amounts during final oocyte maturation may be responsible for the rapid increase in the follicular production of maturation-inducing hormone 17-alpha,20-beta-DP.

Catalytic activity

Cholesterol + reduced adrenal ferredoxin + O(2) = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H(2)O.

Cofactor

Heme group By similarity.

Pathway

Lipid metabolism; C21-steroid hormone metabolism.

Subcellular location

Mitochondrion membrane.

Tissue specificity

Not found in early vitellogenic follicles, barely detected in postvitellogenic follicles and abundant in post ovulatory follicles.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Biological processCholesterol metabolism
Lipid metabolism
Steroid metabolism
Steroidogenesis
   Cellular componentMembrane
Mitochondrion
   DomainTransit peptide
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

   Cellular componentmitochondrial membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Transit peptide1 – 3939Mitochondrion Potential
Chain40 – 514475Cytochrome P450 11A1, mitochondrial

Sites

Metal binding4581Iron (heme axial ligand) By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q07217-1 [UniParc].

Last modified October 1, 1994. Version 1.
Checksum: 0C6F49ECE8FF38FD

FASTA51459,137
        10         20         30         40         50         60 
MMVSWSVCRS SLALPACGLP SARHNSSMPV VRQALSPDNS STVQNFSEIP GLWRNGLANL 

        70         80         90        100        110        120 
YSFWKLDGFR NIHRVMVHNF NTFGPIYREK IGYYDSVNII KPEMPAILFK AEGHYPKRLT 

       130        140        150        160        170        180 
VEAWTSYRDY RNRKYGVLLK NGEDWRSNRV ILNREVISPK VLGNFVPLLD EVGQDFVARV 

       190        200        210        220        230        240 
HKKIERSGQD KWTTDLSQEL FKYALESVGS VLYGERLGLM LDYINPEAQH FIDCISLMFK 

       250        260        270        280        290        300 
TTSPMLYIPP AMLRRVGAKI WRDHVEAWDG IFNQADRCIQ NIYRTMRQDT NTHGKYPGVL 

       310        320        330        340        350        360 
ASLLMLDKLS IEDIKASVTE LMAGGVDTTS ITLLWTLYEL ARHPDLQEEL RAEVAVARQS 

       370        380        390        400        410        420 
TQGDMLQMLK MIPLVKGALK ETLRLHPVAV SLQRYITEEI VIQNYHIPCG TLVQLGLYAM 

       430        440        450        460        470        480 
GRDPDVFPRP EKYLPSRWLR TENQYFRSLG FGFGPRQCLG RRIAETEMQL FLIHMLENFR 

       490        500        510 
VDKQRQVEVH STFELILLPE KPILLTLKPL KSGQ

« Hide

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References

[1]"Rainbow trout ovarian cholesterol side-chain cleavage cytochrome P450 (P450scc). cDNA cloning and mRNA expression during oogenesis."
Takahashi M., Tanaka M., Sakai N., Adachi S., Miller W.L., Nagahama Y.
FEBS Lett. 319:45-48(1993) [PubMed: 8454060] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

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Cross-references

Sequence databases

S57305 mRNA. Translation: AAB25804.1.
PIRS32197.

3D structure databases

HSSPHSSP built from PDB template 1SCC based on UniProtKB P00189.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ07217.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomQ07217.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameCP11A_ONCMY
AccessionPrimary (citable) accession number: Q07217
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 2, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents