Reviewed,
UniProtKB/Swiss-Prot Q02315 (CP51_ISSOR)
Last modified
September 2, 2008.
Version 41.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Cytochrome P450 51 EC=1.14.13.70 Alternative name(s): CYPLI P450-LIA1 Sterol 14-alpha demethylase Lanosterol 14-alpha demethylase P450-14DM | ||
| Gene names |
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| Organism | Issatchenkia orientalis (Yeast) (Candida krusei) | ||
| Taxonomic identifier | 4909 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Issatchenkia |
Protein attributes
| Sequence length | 414 AA. |
| Sequence status | Fragment. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. |
| Catalytic activity | Obtusifoliol + 3 O(2) + 3 NADPH = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O. |
| Cofactor | Heme group By similarity. |
| Pathway | Steroid metabolism; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6. |
| Subcellular location | MembranePotential. Membrane; Single-pass membrane protein. |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Cellular component | Membrane |
| Ligand | Heme Iron Metal-binding NADP |
| Molecular function | Monooxygenase Oxidoreductase |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Rapid detection and identification of Candida albicans and Torulopsis (Candida) glabrata in clinical specimens by species-specific nested PCR amplification of a cytochrome P-450 lanosterol-alpha-demethylase (L1A1) gene fragment." Burgener-Kairuz P., Zuber J.P., Jaunin P., Buchman T.G., Bille J., Rossier M. J. Clin. Microbiol. 32:1902-1907(1994) [PubMed: 7989540] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 6258 / CBS 573 / DSM 6128 / JCM 1609 / NBRC 1064. |
Cross-references
Sequence databases | |
|---|---|
| S75391 Genomic DNA. Translation: AAB32680.1. | |
3D structure databases | |
| ModBase | Search... |
Family and domain databases | |
| InterPro | IPR001128. Cyt_P450. IPR002403. Cyt_P450_E_grp-IV. [Graphical view] |
| Gene3D | G3DSA:1.10.630.10. Cyt_P450. 1 hit. |
| PANTHER | PTHR19383. Cyt_P450. 1 hit. |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PRINTS | PR00465. EP450IV. PR00385. P450. |
| PROSITE | PS00086. CYTOCHROME_P450. Partial match. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | CP51_ISSOR | ||||||||
| Accession | Primary (citable) accession number: Q02315 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
