Reviewed,
UniProtKB/Swiss-Prot P50859 (CP51_CANGA)
Last modified
September 2, 2008.
Version 54.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Cytochrome P450 51 EC=1.14.13.70 Alternative name(s): CYPLI P450-LIA1 Sterol 14-alpha-demethylase Lanosterol 14-alpha demethylase P450-14DM | ||||||
| Gene names |
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| Organism | Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome] | ||||||
| Taxonomic identifier | 5478 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida |
Protein attributes
| Sequence length | 533 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol By similarity. |
| Catalytic activity | Obtusifoliol + 3 O(2) + 3 NADPH = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O. |
| Cofactor | Heme group By similarity. |
| Pathway | Steroid metabolism; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6. |
| Subcellular location | MembranePotential. Membrane; Single-pass membrane protein. |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Cellular component | Membrane |
| Ligand | Heme Iron Metal-binding NADP |
| Molecular function | Monooxygenase Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility." Geber A., Hitchcock C.A., Swartz J.E., Pullen F.S., Marsden K.E., Kwon-Chung K.J., Bennett J.E. Antimicrob. Agents Chemother. 39:2708-2717(1995) [PubMed: 8593007] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 2001-L5. |
| [2] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.  Souciet J.-L.Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65. |
| [3] | "Rapid detection and identification of Candida albicans and Torulopsis (Candida) glabrata in clinical specimens by species-specific nested PCR amplification of a cytochrome P-450 lanosterol-alpha-demethylase (L1A1) gene fragment." Burgener-Kairuz P., Zuber J.P., Jaunin P., Buchman T.G., Bille J., Rossier M. J. Clin. Microbiol. 32:1902-1907(1994) [PubMed: 7989540] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-473. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65. |
Cross-references
Sequence databases | |
|---|---|
| L40389 Genomic DNA. Translation: AAB02329.1. CR380951 Genomic DNA. Translation: CAG58795.1. S75389 Genomic DNA. Translation: AAB32679.1. | |
| RefSeq | XP_445876.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2887532. |
| KEGG | cgr:CAGL0E04334g. |
Phylogenomic databases | |
| HOGENOM | P50859. |
Family and domain databases | |
| InterPro | IPR001128. Cyt_P450. [Graphical view] |
| PANTHER | PTHR19383. Cyt_P450. 1 hit. |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProDom | P50859. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| DrugBank | DB00639. Butoconazole. DB01167. Itraconazole. DB01110. Miconazole. |
| ProtoNet | Search... |
Entry information
| Entry name | CP51_CANGA | ||||||||
| Accession | Primary (citable) accession number: P50859 Secondary accession number(s): Q02312 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |
