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Reviewed, UniProtKB/Swiss-Prot P46634 (CP7A1_CRIGR)

Last modified September 2, 2008. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 7A1
    EC=1.14.13.17
Alternative name(s):
    CYPVII
    Cholesterol 7-alpha-monooxygenase
    Cholesterol 7-alpha-hydroxylase
Gene names
Name: CYP7A1
Synonyms: CYP7
OrganismCricetulus griseus (Chinese hamster)
Taxonomic identifier10029 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Cricetulus

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Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Cholesterol + NADPH + O(2) = 7-alpha-hydroxycholesterol + NADP(+) + H(2)O.

Cofactor

Heme group By similarity.

Pathway

Lipid metabolism; bile acid biosynthesis.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Biological processCholesterol metabolism
Lipid metabolism
Steroid metabolism
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
NADP
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 504504Cytochrome P450 7A1

Sites

Metal binding4441Iron (heme axial ligand) By similarity

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Sequences

Sequence LengthMass (Da)Tools
P46634-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: BD5E521D0C195257

FASTA50457,447
        10         20         30         40         50         60 
MMTISLIWGI AMVVCCCIWV IFDRRRRKAG EPPLENGLIP YLGCALKFGS NPLEFLRANQ 

        70         80         90        100        110        120 
RKHGHVFTCK LMGKYVHFIT NSLSYHKVLC HGKYFDWKKF HYTTSAKAFG HRSIDPNDGN 

       130        140        150        160        170        180 
TTENINNTFT KTLQGDALHS LSEAMMQNLQ FVLRPPDLPK SKSDAWVTEG MYAFCYRVMF 

       190        200        210        220        230        240 
EAGYLTLFGR DTSKPDTQRV LILNNLNSFK QFDQVFPALV AGLPIHLFKA AHKAREQLAE 

       250        260        270        280        290        300 
GLKHENLSVR DQVSELIRLR MFLNDTLSTF DDMEKAKTHL AILWASQANT IPATFWSLFQ 

       310        320        330        340        350        360 
MIRSPDALRA ASEEVNGALQ SAGQKLSSEG NAIYLDQIQL NNLPVLDSII KEALRLSSAS 

       370        380        390        400        410        420 
LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPAI YPDPLTFKYD RYLDENKKAK 

       430        440        450        460        470        480 
TSFYSNGNKL KYFYMPFGSG ATICPGRLFA VQEIKQFLIL MLSYFELELV ESHVKCPPLD 

       490        500 
QSRAGLGILP PLNDIEFKYK LKHL

« Hide

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References

[1]"Genomic cloning, sequencing, and analysis of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7)."
Crestani M., Galli G., Chiang J.Y.
Arch. Biochem. Biophys. 306:451-460(1993) [PubMed: 8105753] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Liver.

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Cross-references

Sequence databases

L04690 Genomic DNA. Translation: AAA03751.1.
PIRS39399.

3D structure databases

ModBaseSearch...

Phylogenomic databases

HOVERGENP46634.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00465. EP450IV.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP46634.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameCP7A1_CRIGR
AccessionPrimary (citable) accession number: P46634
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 2, 2008
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents