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Reviewed, UniProtKB/Swiss-Prot P46194 (CP19A_BOVIN)

Last modified September 2, 2008. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthetase
    P-450AROM
Gene names
Name: CYP19A1
Synonyms: CYP19
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   PTMPhosphoprotein

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 503503Cytochrome P450 19A1

Sites

Metal binding4371Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue1621Phosphothreonine By similarity

Experimental info

Sequence conflict2161K → N in AAA62244. Ref.1
Sequence conflict2601E → A in AAA62244. Ref.1
Sequence conflict4361A → G in AAA62244. Ref.1
Sequence conflict4431T → A in AAA62244. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P46194-1 [UniParc].

Last modified August 29, 2001. Version 3.
Checksum: 47C70292D21AFF97

FASTA50358,090
        10         20         30         40         50         60 
MLLEVLNPRH YNVTSMVSEV VPIASIAILL LTGFLLLVWN YEDTSSIPGP SYFLGIGPLI 

        70         80         90        100        110        120 
SHCRFLWMGI GSACNYYNKM YGEFMRVWVC GEETLIISKS SSMFHVMKHS HYISRFGSKL 

       130        140        150        160        170        180 
GLQFIGMHEK GIIFNNNPAL WKAVRPFFTK ALSGPGLVRM VTICADSITK HLDRLEEVCN 

       190        200        210        220        230        240 
DLGYVDVLTL MRRIMLDTSN MLFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL 

       250        260        270        280        290        300 
CRKYEKSVKD LKDAMEILIE EKRHRISTAE KLEDSIDFAT ELIFAEKRGE LTRENVNQCI 

       310        320        330        340        350        360 
LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AIIREIQTVV GERDIRIDDM QKLKVVENFI 

       370        380        390        400        410        420 
NESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNLGR MHRLEFFPKP NEFTLENFAK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRACAGK YITMVMMKVV LVTLLRRFHV QTLQGRCVEK MQKKNDLSLH 

       490        500 
PDETRDRLEM IFTPRNSDKC LER

« Hide

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References

[1]"Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450."
Hinshelwood M.M., Corbin C.J., Tsang P.C., Simpson E.R.
Endocrinology 133:1971-1977(1993) [PubMed: 8404644] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]"Novel aromatase transcripts from bovine placenta contain repeated sequence motifs."
Vanselow J., Furbass R.
Gene 154:281-286(1995) [PubMed: 7890178] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[3]"Tissue-specific expression of the bovine aromatase-encoding gene uses multiple transcriptional start sites and alternative first exons."
Furbass R., Kalbe C., Vanselow J.
Endocrinology 138:2813-2819(1997) [PubMed: 9202222] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]Furbass R.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 443.

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Cross-references

Sequence databases

U18447 mRNA. Translation: AAA62244.1.
Z32741 mRNA. Translation: CAA83651.1.
Z69242 expand/collapse EMBL AC list , Z69243, Z69244, Z69245, Z69246, Z69247, Z69248, Z69249, Z69250 Genomic DNA. Translation: CAC12940.1.
PIRI46015.
RefSeqNP_776730.1.
UniGeneBt.4447

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000014890. Bos taurus. [Contig view]
GeneID281740.
KEGGbta:281740.

Phylogenomic databases

HOVERGENP46194.

Family and domain databases

InterProIPR001128. Cyt_P450.
[Graphical view]
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP46194.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameCP19A_BOVIN
AccessionPrimary (citable) accession number: P46194
Secondary accession number(s): Q29445, Q29453
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 29, 2001
Last modified: September 2, 2008
This is version 57 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents