Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot P32031 (SLP2_DROME)

Last modified November 4, 2008. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Fork head domain transcription factor slp2
Alternative name(s):
    Sloppy paired locus protein 2
Gene names
Name: slp2
ORF Names: CG2939
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Hide | Top

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Transcription factor involved in segmentation. May function primarily as a segment polarity gene. Different levels of slp activity seem to be required in different segments.

Subcellular location

Nucleus.

Tissue specificity

Expressed in the posterior half of each parasegment just anterior to the parasegmental boundary.

Developmental stage

Expression at 3-6 hours of embryogenesis. Strong re-expression in first-instar larvae.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Sequence caution

The sequence AAF51057.1 differs from that shown. Reason: Erroneous gene model prediction.

Hide | Top

Ontologies

Keywords

   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionDevelopmental protein
Segmentation polarity protein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processsegment polarity determination

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Fork head domain transcription factor slp2
PRO_0000091915

Regions

DNA binding179 – 27092Fork-head
Compositional bias94 – 10411Asn-rich

Natural variations

Natural variant3621R → P in strain: Oregon-R.
Natural variant3781S → N in strain: Oregon-R.
Natural variant3871R → Q in strain: Canton-S.
Natural variant4101H → Q in strain: Oregon-R.
Natural variant4161T → I in strain: Oregon-R.

Experimental info

Sequence conflict4131P → L in CAA46892 and CAA46891. Ref.1

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P32031-1 [UniParc].

Last modified November 2, 2001. Version 2.
Checksum: 3D9744F413585C8D

FASTA44550,660
        10         20         30         40         50         60 
MVKIEEGLPS SEISAHSLHF QHHHHPLPPT THHSALQSPH PVGLNLTNLM KMARTPHLKS 

        70         80         90        100        110        120 
SFSINSILPE TVEHHDEDEE EDVEKKSPAK FPPNHNNNNL NTTNWGSPED HEAESDPESD 

       130        140        150        160        170        180 
LDVTSMSPAP VANPNESDPD EVDEEFVEED IECDGETTDG DAENKSNDGK PVKDKKGNEK 

       190        200        210        220        230        240 
PPYSYNALIM MAIRQSSEKR LTLNGIYEYI MTNHPYYRDN KQGWQNSIRH NLSLNKCFVK 

       250        260        270        280        290        300 
VPRHYDDPGK GNYWMLDPSA EDVFIGGSTG KLRRRTTAAS RSRLAAFKRS LIGPMFPGLA 

       310        320        330        340        350        360 
AYPQFGQFLT YPPTAPSLLA SMYQRYNPFA PKGGPGHPGL PPGLRDYPDH RDLKDRQDHH 

       370        380        390        400        410        420 
HRPSSHHPRA VSSTSDCSTN SCCINMRQPP LWRLIKGNSR WRQHRRRHNH RPPITTHTWR 

       430        440 
WVRRPFRLAA IPRDPRHSLF TNPSP

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors."
Grossniklaus U., Pearson R.K., Gehring W.J.
Genes Dev. 6:1030-1051(1992) [PubMed: 1317319] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: Canton-S and Oregon-R.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.

Hide | Top

Cross-references

Sequence databases

X66098 Genomic DNA. Translation: CAA46892.1.
X66097 mRNA. Translation: CAA46891.1.
AE014134 Genomic DNA. Translation: AAF51057.1. Sequence problems.
PIRS23055.
S23056.
RefSeqNP_476834.1.
UniGeneDm.3388

3D structure databases

HSSPHSSP built from PDB template 1D5V based on UniProtKB Q99958.
ModBaseSearch...

Genome annotation databases

GeneID33608.
KEGGdme:Dmel_CG2939.

Organism-specific databases

FlyBaseFBgn0004567. slp2.

Family and domain databases

InterProIPR001766. TF_Fork_head.
IPR011991. Wing_hlx_DNA_bd.
[Graphical view]
Gene3DG3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PANTHERPTHR11829. Fork_box_protein. 1 hit.
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
ProDomPD000425. TF_Fork_head. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio784423.

Hide | Top

Entry information

Entry nameSLP2_DROME
AccessionPrimary (citable) accession number: P32031
Secondary accession number(s): Q9VQV5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 2, 2001
Last modified: November 4, 2008
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Hide | Top

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents