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Reviewed, UniProtKB/Swiss-Prot P30437 (CP17A_ONCMY)

Last modified September 2, 2008. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 17A1
    EC=1.14.99.9
Alternative name(s):
    CYPXVII
    P450-C17
      Short name=P450c17
    Steroid 17-alpha-hydroxylase/17,20 lyase
Gene names
Name: cyp17a1
Synonyms: cyp17
OrganismOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifier8022 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus

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Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.

Catalytic activity

A steroid + AH(2) + O(2) = a 17-alpha-hydroxysteroid + A + H(2)O.

Cofactor

Heme group By similarity.

Enzyme regulation

Regulated predominantly by intracellular cAMP levels.

Pathway

Lipid metabolism; steroid biosynthesis.

Subcellular location

MembranePotential. Membrane; Single-pass membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Biological processSteroidogenesis
   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 514514Cytochrome P450 17A1

Sites

Metal binding4491Iron (heme axial ligand) By similarity

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Sequences

Sequence LengthMass (Da)Tools
P30437-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 9AC19961F921DCCB

FASTA51457,408
        10         20         30         40         50         60 
MAWFLCMCVF SVVGLGLLLL QVKLRRSLET RGGPPSLPVF PLIGSLLSLR SNQAPHVLFQ 

        70         80         90        100        110        120 
KLQQKYGHTY SLMMGPHTVI LVNHHQHAKE VLLKKGKIFA GRPRTVTTDL LTRDGKDIAF 

       130        140        150        160        170        180 
ADYGATWRFH RKTVHGALCM FGEGSASIEK IICREALSLC DTLRESGSAS LDLSPELTRA 

       190        200        210        220        230        240 
VTNVVCSLCF SSSYCRGDPE FEAMLQFSQG IVDTVAKDSL VDIFPWLQVF PNADLRLLKQ 

       250        260        270        280        290        300 
CVSIRDKLLQ KKYEEHKSDY SDHEQRDLLD ALLRAKRSAE NNNTAEITME TVGLSEDHLL 

       310        320        330        340        350        360 
MTVGDIFGAG VETTSTVLKW AIAYLIHHPQ VQQRIQEELD SVVGGDRTPQ LSDRGSLPYL 

       370        380        390        400        410        420 
EATIREVLRI RPVAPLLIPH VAQTDTSIGK FTVRKGARII INLWSLHHDE KEWKNPEMFD 

       430        440        450        460        470        480 
PGRFLNEEGT GLCIPSPSYL PFGAGVRVCL GEALAKMEIF LFLSWILQRL TMTVSPGQPL 

       490        500        510 
PSLEGKFGVV LQPVKYKVNA TPRAGWEKSH LQTS

« Hide

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References

[1]"Rainbow trout cytochrome P-450c17 (17 alpha-hydroxylase/17,20-lyase). cDNA cloning, enzymatic properties and temporal pattern of ovarian P-450c17 mRNA expression during oogenesis."
Sakai N., Tanaka M., Adachi S., Miller W.L., Nagahama Y.
FEBS Lett. 301:60-64(1992) [PubMed: 1451787] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

X65800 mRNA. Translation: CAA46675.1.
PIRS21125.
RefSeqNP_001118219.1.

3D structure databases

HSSPHSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBaseSearch...

Genome annotation databases

GeneID100137017.

Phylogenomic databases

HOVERGENP30437.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP30437.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameCP17A_ONCMY
AccessionPrimary (citable) accession number: P30437
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 2, 2008
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents