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Reviewed, UniProtKB/Swiss-Prot P29774 (ETS3_DROME)

Last modified July 22, 2008. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    DNA-binding protein D-ETS-3
Gene names
Name: Ets65A
Synonyms: ETS3
ORF Names: CG7018
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Subcellular location

Nucleus.

Tissue specificity

Embryonic ventral nervous system, higher in the thoracic than abdominal segments.

Developmental stage

Expressed throughout development.

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

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Ontologies

Keywords

   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   LigandDNA-binding
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processregulation of transcription, DNA-dependent Ref.6

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P29774-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: P29774-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.
     234-260: ISGSKSSNTSGTGGGASASGGGGSALY → MLDIKSSADYLSRSTGSFSNFSMLFAD
Notes: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 490490DNA-binding protein D-ETS-3

Regions

DNA binding317 – 39781ETS
Compositional bias188 – 28093Ser-rich

Natural variations

Alternative sequence1 – 233233Missing in isoform B.
Alternative sequence234 – 26027ISGSK…GSALY → MLDIKSSADYLSRSTGSFSN FSMLFAD in isoform B.

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Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified February 28, 2003. Version 3.
Checksum: B5BB281B13DDEA97

FASTA49052,055
        10         20         30         40         50         60 
MYENSCSYQT ALDLKRVSPP TLAQVKTEEC LALGQCSPEW TSYRFHQSTF EQLKQSVEKA 

        70         80         90        100        110        120 
KAALQDRSSF FGASSAFSDI YSSQRLTDSL DTLPVQSGNG GGNCLGLPHN PNVGVGVAGV 

       130        140        150        160        170        180 
LNYNAVSSST AGVLSSSGNG VQRHRLDTLQ PPSGCSPAVT QHGVITSSAG QVTSGTLDAV 

       190        200        210        220        230        240 
SAAPALPSLT ASSSSHVEHK VRADKSTLDC ATTSSHAAAP SSSSSASDHQ QGRISGSKSS 

       250        260        270        280        290        300 
NTSGTGGGAS ASGGGGSALY SSYKSSWGSH SSTQSQGYSS NALGIKHDPH SQLRQPDPYQ 

       310        320        330        340        350        360 
MFGPTSSRLA SSGSGQIQLW QFLLELLSDS NNASCITWEG TNGEFKLTDP DEVARRWGER 

       370        380        390        400        410        420 
KSKPNMNYDK LSRALRYYYD KNIMTKVHGK RYAYKFDFQG LAAATQPAAS DPTYKYQSDL 

       430        440        450        460        470        480 
FMTPYHHSAK LSSFMSPHHG MTSSSASIFP SAASWGNWGS PATNLYQPHS MSHVTPSHVA 

       490 
PHLSSYPHYA

« Hide

Isoform B [UniParc].

Checksum: 4C6319AF07E5DA80
Show »

25728,701

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References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Strain: Berkeley.
Tissue: Head.
[4]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A. expand/collapse author list , Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[5]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A. expand/collapse author list , Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Strain: Berkeley.
Tissue: Head.
[6]"Isolation and characterization of five Drosophila genes that encode an ets-related DNA binding domain."
Chen T., Bunting M., Karim F.D., Thummel C.S.
Dev. Biol. 151:176-191(1992) [PubMed: 1577186] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 314-375, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: Canton-S.
Tissue: Larva.

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Cross-references

Sequence databases

AE014296 Genomic DNA. Translation: AAF50697.2.
AE014296 Genomic DNA. Translation: AAF50696.2.
AY060316 mRNA. Translation: AAL25355.1.
AY060250 mRNA. Translation: AAR88562.1.
BT003453 mRNA. Translation: AAO39456.1.
M88473 Genomic DNA. Translation: AAA28450.2.
PIRS28820.
RefSeqNP_523945.2.
NP_729142.1.
UniGeneDm.2825

3D structure databases

HSSPHSSP built from PDB template 1FLI based on UniProtKB Q01543.
SMRP29774. Positions 313-407.
ModBaseSearch...

Genome annotation databases

EnsemblCG7018. Drosophila melanogaster. [Contig view]
GeneID38700.
KEGGdme:Dmel_CG7018.
NMPDRfig|7227.3.peg.8494.

Organism-specific databases

FlyBaseFBgn0005658. Ets65A.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-015405-MON.

Gene expression databases

ArrayExpressP29774.
GermOnlineCG7018. Drosophila melanogaster.

Family and domain databases

InterProIPR000418. Ets.
IPR011991. Wing_hlx_DNA_bd.
[Graphical view]
Gene3DG3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
PfamPF00178. Ets. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
[Graphical view]
PROSITEPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProDomP29774.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameETS3_DROME
AccessionPrimary (citable) accession number: P29774
Secondary accession number(s): Q86P68 expand/collapse secondary AC list , Q95T62, Q95TB2, Q9VRU3, Q9VRU4, Q9VRU5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: February 28, 2003
Last modified: July 22, 2008
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents