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Reviewed, UniProtKB/Swiss-Prot P27786 (CP17A_MOUSE)

Last modified July 22, 2008. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 17A1
    EC=1.14.99.9
Alternative name(s):
    CYPXVII
    P450-C17
      Short name=P450c17
    Steroid 17-alpha-hydroxylase/17,20 lyase
Gene names
Name: Cyp17a1
Synonyms: Cyp17
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activity

A steroid + AH(2) + O(2) = a 17-alpha-hydroxysteroid + A + H(2)O.

Cofactor

Heme group By similarity.

Enzyme regulation

Regulated predominantly by intracellular cAMP levels.

Pathway

Lipid metabolism; steroid biosynthesis.

Subcellular location

MembranePotential. Membrane; Single-pass membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Biological processSteroidogenesis
   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

   Biological processglucocorticoid biosynthetic process

Inferred from direct assay. Source: MGI

   Cellular componentaxon

Inferred from direct assay. Source: MGI

cell soma

Inferred from direct assay. Source: MGI

mitochondrion

Inferred from direct assay. Source: MGI

   Molecular functionsteroid 17-alpha-monooxygenase activity

Inferred from direct assay. Source: MGI

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 507507Cytochrome P450 17A1

Sites

Metal binding4411Iron (heme axial ligand) By similarity

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Sequences

Sequence LengthMass (Da)Tools
P27786-1 [UniParc].

Last modified August 1, 1992. Version 1.
Checksum: C0916193356EFEBD

FASTA50757,638
        10         20         30         40         50         60 
MWELVGLLLL ILAYFFWPKS KTPNAKFPRS LPFLPLVGSL PFLPRRGHMH ANFFKLQEKY 

        70         80         90        100        110        120 
GPIYSLRLGT TTAVIVGHYQ LAREVLVKKG KEFSGRPQMV TLGLLSDQGK GVAFADSSSS 

       130        140        150        160        170        180 
WQLHRKLVFS TFSLFRDDQK LEKMICQEAN SLCDLILTYD GESRDLSTLI FKSVINIICT 

       190        200        210        220        230        240 
ICFNISFENK DPILTTIQTF TEGIVDVLGH SDLVDIFPWL KIFPNKNLEM IKEHTKIREK 

       250        260        270        280        290        300 
TLVEMFEKCK EKFNSESLSS LTDILIQAKM NAENNNTGEG QDPSVFSDKH ILVTVGDIFG 

       310        320        330        340        350        360 
AGIETTSSVL NWILAFLVHN PEVKRKIQKE IDQYVGFSRT PSFNDRTHLL MLEATIREVL 

       370        380        390        400        410        420 
RIRPVAPLLI PHKANIDSSI GEFAIPKDTH VIINLWALHH DKNEWDQPDR FMPERFLDPT 

       430        440        450        460        470        480 
GSHLITPTPS YLPFGAGPRS CIGEALARQE LFIFMALLLQ RFDFDVSDDK QLPCLVGDPK 

       490        500 
VVFLIDPFKV KITVRQAWKD AQVEVST

« Hide

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References

[1]"Isolation, characterization, and chromosomal mapping of mouse P450 17 alpha-hydroxylase/C17-20 lyase."
Youngblood G.L., Sartorius C., Taylor B.A., Payne A.H.
Genomics 10:270-275(1991) [PubMed: 1840559] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

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Cross-references

Sequence databases

M64863 mRNA. Translation: AAA39877.1.
PIRA39072.
RefSeqNP_031835.3.
UniGeneMm.1262

3D structure databases

HSSPHSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBaseSearch...

PTM databases

PhosphoSiteP27786.

Genome annotation databases

EnsemblENSMUSG00000003555. Mus musculus. [Contig view]
GeneID13074.
KEGGmmu:13074.

Organism-specific databases

MGIMGI:88586. Cyp17a1.

Phylogenomic databases

HOGENOMP27786.
HOVERGENP27786.

Gene expression databases

ArrayExpressP27786.
GermOnlineENSMUSG00000003555. Mus musculus.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP27786.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameCP17A_MOUSE
AccessionPrimary (citable) accession number: P27786
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 22, 2008
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents