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Reviewed, UniProtKB/Swiss-Prot P25171 (RCC1_DROME)

Last modified November 25, 2008. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Regulator of chromosome condensation
Alternative name(s):
    Chromatin-binding protein Bj1
Gene names
Name: Bj1
ORF Names: CG10480
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin.

Subcellular location

Nucleus. Cytoplasm. Note= Becomes dispersed throughout the cytoplasm during mitosis. Is associated with chromatin throughout mitosis.

Sequence similarities

Contains 7 RCC1 repeats.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 547547Regulator of chromosome condensation
PRO_0000206633

Regions

Repeat41 – 9151RCC1 1
Repeat92 – 14352RCC1 2
Repeat145 – 19551RCC1 3
Repeat197 – 25761RCC1 4
Repeat260 – 31051RCC1 5
Repeat311 – 36252RCC1 6
Repeat363 – 41654RCC1 7
Repeat417 – 45438Bj1 1
Repeat455 – 48935Bj1 2
Repeat490 – 51930Bj1 3
Compositional bias520 – 54728Glu/Lys-rich

Amino acid modifications

Modified residue2861Phosphothreonine
Modified residue5121Phosphothreonine
Modified residue5261Phosphoserine
Modified residue5311Phosphothreonine

Experimental info

Sequence conflict4901V → A in CAA41417. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P25171-1 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 77D9744EBAF4597A

FASTA54758,851
        10         20         30         40         50         60 
MPRRKALTNN NNAGEAEQQP PKAKRARIAF HLELPKRRTV LGNVLVCGNG DVGQLGLGED 

        70         80         90        100        110        120 
ILERKRLSPV AGIPDAVDIS AGGMHNLVLT KSGDIYSFGC NDEGALGRDT SEDGSESKPD 

       130        140        150        160        170        180 
LIDLPGKALC ISAGDSHSAC LLEDGRVFAW GSFRDSHGNM GLTIDGNKRT PIDLMEGTVC 

       190        200        210        220        230        240 
CSIASGADHL VILTTAGKVF TVGCAEQGQL GRLSERSISG EGRRGKRDLL RPTQLIITRA 

       250        260        270        280        290        300 
KPFEAIWATN YCTFMRESQT QVIWATGLNN FKQLAHETKG KEFALTPIKT ELKDIRHIAG 

       310        320        330        340        350        360 
GQHHTVILTT DLKCSVVGRP EYGRLGLGDV KDVVEKPTIV KKLTEKIVSV GCGEVCSYAV 

       370        380        390        400        410        420 
TIDGKLYSWG SGVNNQLGVG DGDDELEPIV VVSKNTQGKH MLLASGGGQH AIFLVKADKQ 

       430        440        450        460        470        480 
DQKENVPVKV SGSSSISKKD KTPPQDNVDK EAENVDKQEQ KENLPAKAST SSKKNKTPPQ 

       490        500        510        520        530        540 
DNADKEAENV DKQEQKENLP AKASTSSKKI KTPPQDDAAE EVEEESAQEP TPKKAKKPAA 


KRGGKKT

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References

« Hide 'large scale' references
[1]"The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1."
Frasch M.
EMBO J. 10:1225-1236(1991) [PubMed: 2022188] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]"Mutation of the hamster cell cycle gene RCC1 is complemented by the homologous genes of Drosophila and S.cerevisiae."
Ohtsubo M., Yoshida T., Seino H., Nishitani H., Clark K.L., Sprague G.F. Jr., Frasch M., Nishimoto T.
EMBO J. 10:1265-1273(1991) [PubMed: 2022190] [Abstract]
Cited for: CHARACTERIZATION, SUBCELLULAR LOCATION.
[6]"Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos."
Trieselmann N., Wilde A.
Curr. Biol. 12:1124-1129(2002) [PubMed: 12121620] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[7]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-286; THR-512; SER-526 AND THR-531, MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X58530 Genomic DNA. Translation: CAA41417.1.
AE014296 Genomic DNA. Translation: AAF50726.1.
AE014296 Genomic DNA. Translation: AAF50727.1.
AE014296 Genomic DNA. Translation: AAN12235.1.
AY070540 mRNA. Translation: AAL48011.1.
PIRS15028.
RefSeqNP_523943.1.
NP_729118.1.
NP_729119.1.
UniGeneDm.8023

3D structure databases

HSSPHSSP built from PDB template 1I2M based on UniProtKB P18754.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:17766N.
IntActP25171.

Genome annotation databases

EnsemblCG10480. Drosophila melanogaster. [Contig view]
GeneID38669.
KEGGdme:Dmel_CG10480.

Organism-specific databases

FlyBaseFBgn0002638. Bj1.

Phylogenomic databases

HOGENOMP25171.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-015374-MON.
DMEL-XXX-02:DMEL-XXX-02-015375-MON.
DMEL-XXX-02:DMEL-XXX-02-015376-MON.

Gene expression databases

ArrayExpressP25171.
GermOnlineCG10480. Drosophila melanogaster.

Family and domain databases

InterProIPR000408. Reg_chr_condens.
IPR009091. Reg_csome_cond/b-lactamase_inh.
[Graphical view]
Gene3DG3DSA:2.130.10.30. Reg_csome_cond/b-lactamase_inh. 1 hit.
PfamPF00415. RCC1. 5 hits.
[Graphical view]
PRINTSPR00633. RCCNDNSATION.
PROSITEPS00625. RCC1_1. 1 hit.
PS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 6 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio809817.

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Entry information

Entry nameRCC1_DROME
AccessionPrimary (citable) accession number: P25171
Secondary accession number(s): A4V1J1, Q9VRR5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 1, 2001
Last modified: November 25, 2008
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents