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Reviewed, UniProtKB/Swiss-Prot P24460 (CP2BB_CANFA)

Last modified November 4, 2008. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 2B11
    EC=1.14.14.1
Alternative name(s):
    CYPIIB11
    P450 PBD-2
Gene names
Name: CYP2B11
OrganismCanis familiaris (Dog)
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

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Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. This isozyme seems responsible for metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.

Catalytic activity

RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By phenobarbital.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   PTMPhosphoprotein

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

microsome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionunspecific monooxygenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Cytochrome P450 2B11
PRO_0000051686

Sites

Metal binding4361Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue1281Phosphoserine; by PKA By similarity

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Sequences

Sequence LengthMass (Da)Tools
P24460-1 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 8E9EA639B4B5E4D3

FASTA49456,267
        10         20         30         40         50         60 
MELSVLLLLA LLTGLLLLMA RGHPKAYGHL PPGPRPLPIL GNFLQMDRKG LLKSFLRLQE 

        70         80         90        100        110        120 
KYGDVFTVYL GPRRTVMLCG IDAIREALVD NAEAFSGRGK IAVVEPVFQG YGVVFANGER 

       130        140        150        160        170        180 
WKTLRRFSLA TMRDFGMGKR SVEERIQEEA QCLVEELRKT EGVLQDPTFF FHSMTANIIC 

       190        200        210        220        230        240 
SIVFGKRFGY KDPEFLRLMN LFYVSFALIS SFSSQMFELF HSFLKYFPGT HRQVYNNLQE 

       250        260        270        280        290        300 
IKAFIARMVE KHRETLDPSA PRDFIDAYLI RMDKEKAEPS SEFHHRNLID TALSLFFAGT 

       310        320        330        340        350        360 
ETTSTTLRYG FLLMLKYPHI AERIYKEIDQ VIGPHRLPSL DDRAKMPYTD AVIHEIQRFG 

       370        380        390        400        410        420 
DLLPIGVPHM VTKDICFRGY IIPKGTEVFP ILHSALNDPH YFEKPDVFNP DHFLDANGAL 

       430        440        450        460        470        480 
KKNEAFIPFS IGKRICLGEG IARMELFLFF TTILQNFSVA SPMAPEDIDL TPQEIGVGKL 

       490 
PPVYQISFLS RGGC

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References

[1]"cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl."
Graves P.E., Elhag G.A., Ciaccio P.J., Bourque D.P., Halpert J.R.
Arch. Biochem. Biophys. 281:106-115(1990) [PubMed: 2116765] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Beagle.
Tissue: Liver.

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Cross-references

Sequence databases

M92447 mRNA. Translation: AAA30881.1.
PIRS11305.
RefSeqNP_001006653.1.
UniGeneCfa.3883

3D structure databases

HSSPHSSP built from PDB template 1DT6 based on UniProtKB P00179.
SMRP24460. Positions 28-491.
ModBaseSearch...

Genome annotation databases

EnsemblENSCAFG00000005052. Canis familiaris. [Contig view]
GeneID474177.
KEGGcfa:474177.

Phylogenomic databases

HOVERGENP24460.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

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Entry information

Entry nameCP2BB_CANFA
AccessionPrimary (citable) accession number: P24460
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 4, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents