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Reviewed, UniProtKB/Swiss-Prot P24457 (CP2DB_MOUSE)

Last modified September 2, 2008. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 2D11
    EC=1.14.14.1
Alternative name(s):
    CYPIID11
    P450-16-alpha
    CC
    Testosterone 16-alpha hydroxylase
Gene names
Name: Cyp2d11
Synonyms: Cyp2d-11
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 505505Cytochrome P450 2D11

Sites

Metal binding4471Iron (heme axial ligand)

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Sequences

Sequence LengthMass (Da)Tools
P24457-1 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 402A681AE9ACC68E

FASTA50557,155
        10         20         30         40         50         60 
MELLTGAGLW SVAIFTVIFI LLVDLMHRHQ HWTSRCPPGP VPWPVLGNLL QVDLDNMPYS 

        70         80         90        100        110        120 
LYKLQNRYGD VFSLQMAWKP MVVINGLKAM KEMLLTCGED TADRPPVPIF EYLGVKPGSQ 

       130        140        150        160        170        180 
GVVLAPYGPE WREQRRFSVS TLRNFGLGKK SLEEWVTKEA RHLCDAFTAQ AGQPINPNPM 

       190        200        210        220        230        240 
LNKSTCNVIA SLIFARRFEY EDPFLIRMLK MLKECFTEIS GFIPGVLNEF PIFLRIPGLA 

       250        260        270        280        290        300 
DMVFQGQKSF MAILDNLLTE NRTTWDPDQP PRNLTDAFLA EIEKAKGNAE SSFNDENLRM 

       310        320        330        340        350        360 
VVLDLFTAGM VTTSTTLSWA LLLMILHPDV QRRVQQEIDA VIGQVQHPEM ADQARMPYTN 

       370        380        390        400        410        420 
AVIHEVQRFG TLLHCLCHAS QVVTFTQVQD FLVTKGSTLI PNLSSVLKGE TVWEKPLRFH 

       430        440        450        460        470        480 
PEHFLDAQGH FVKPEAFMPF SAGHRSCLGE ALARMELFLF FTCLLQRFSI SVPDGQPQPS 

       490        500 
NYRVHAIPVA PFPYQLCAVM HEQGH

« Hide

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References

[1]"Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
J. Biol. Chem. 264:2920-2927(1989) [PubMed: 2914938] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

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Cross-references

Sequence databases

M24264 Genomic DNA. Translation: AAA37514.1.
PIRS19169.
UniGeneMm.174372

3D structure databases

HSSPHSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000068085. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:88603. Cyp2d11.

Phylogenomic databases

HOGENOMP24457.
HOVERGENP24457.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP24457.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameCP2DB_MOUSE
AccessionPrimary (citable) accession number: P24457
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 2, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents