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Reviewed, UniProtKB/Swiss-Prot P22816 (MYOD_DROME)

Last modified November 4, 2008. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Myogenic-determination protein
Alternative name(s):
    Protein nautilus
    dMyd
Gene names
Name: nau
Synonyms: MYD
ORF Names: CG10250
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May play an important role in the early development of muscle.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus.

Developmental stage

Initially localized to segmentally repeated clusters of mesodermal cells, and subsequently in at least a subset of growing muscle precursors and mature muscle fibers that exhibit distinct segmental differences.

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain.

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Ontologies

Keywords

   Biological processDifferentiation
Myogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processregulation of striated muscle development

Traceable author statement. Source: FlyBase

   Cellular componentnucleus

Traceable author statement. Source: FlyBase

   Molecular functiontranscription factor activity

Traceable author statement. Source: FlyBase

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Myogenic-determination protein
PRO_0000127374

Regions

Domain174 – 21340Helix-loop-helix motif
DNA binding161 – 17313Basic motif

Experimental info

Sequence conflict28 – 292PT → QA in CAA39629. Ref.2
Sequence conflict95 – 973HPA → NPV in AAF56168. Ref.3
Sequence conflict1311L → H in AAA28477. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P22816-1 [UniParc].

Last modified February 21, 2001. Version 3.
Checksum: 5DD23D24CAA8BEFC

FASTA33236,185
        10         20         30         40         50         60 
MTKYNSGSSE MPAAQTIKQE YHNGYGQPTH PGYGFSAYSQ QNPIAHPGQN PHQTLQNFFS 

        70         80         90        100        110        120 
RFNAVGDASA GNGGAASISA NGSGSSCNYS HANHHPAELD KPLGMNMTPS PIYTTDYDDE 

       130        140        150        160        170        180 
NSSLSSEEHV LAPLVCSSAQ SSRPCLTWAC KACKKKSVTV DRRKAATMRE RRRLRKVNEA 

       190        200        210        220        230        240 
FEILKRRTSS NPNQRLPKVE ILRNAIEYIE SLEDLLQESS TTRDGDNLAP SLSGKSCQSD 

       250        260        270        280        290        300 
YLSSYAGAYL EDKLSFYNKH MEKYGQFTDF DGNANGSSLD CLNLIVQSIN KSTTSPIQNK 

       310        320        330 
ATPSASDTQS PPSSGATAPT SLHVNFKRKC ST

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References

« Hide 'large scale' references
[1]"The Drosophila homologue of vertebrate myogenic-determination genes encodes a transiently expressed nuclear protein marking primary myogenic cells."
Paterson B.M., Walldorf U., Eldridge J., Duebendorfer A., Frasch M., Gehring W.J.
Proc. Natl. Acad. Sci. U.S.A. 88:3782-3786(1991) [PubMed: 1902570] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[2]"Expression of a MyoD family member prefigures muscle pattern in Drosophila embryos."
Michelson A.M., Abmayr S.M., Bate M., Arias A.M., Maniatis T.
Genes Dev. 4:2086-2097(1990) [PubMed: 2176634] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
Tissue: Embryo.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
+Additional computationally mapped references.

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Cross-references

Sequence databases

M68897 mRNA. Translation: AAA28477.1.
X56161 mRNA. Translation: CAA39629.1.
AE014297 Genomic DNA. Translation: AAF56168.1.
PIRA36663.
RefSeqNP_476650.1.
UniGeneDm.4750

3D structure databases

HSSPHSSP built from PDB template 1MDY based on UniProtKB P10085.
SMRP22816. Positions 154-218.
ModBaseSearch...

Protein-protein interaction databases

IntActP22816.

Genome annotation databases

EnsemblCG10250. Drosophila melanogaster. [Contig view]
GeneID42799.
KEGGdme:Dmel_CG10250.

Organism-specific databases

FlyBaseFBgn0002922. nau.

Phylogenomic databases

HOGENOMP22816.

Gene expression databases

ArrayExpressP22816.
GermOnlineCG10250. Drosophila melanogaster.

Family and domain databases

InterProIPR002546. Basic.
IPR001092. HLH_basic.
IPR011598. HLH_DNA_bd.
[Graphical view]
Gene3DG3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
PfamPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
PROSITEPS50888. HLH. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio830620.

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Entry information

Entry nameMYOD_DROME
AccessionPrimary (citable) accession number: P22816
Secondary accession number(s): Q9VCJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: February 21, 2001
Last modified: November 4, 2008
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents