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Reviewed, UniProtKB/Swiss-Prot P22810 (HMOC_DROME)

Last modified May 20, 2008. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesHomeotic protein ocelliless
Also known as:
     Protein orthodenticle
Gene names
Name: oc
Synonyms: Otd
ORF Names: CG12154
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May be a transcriptional regulator involved in specifying cell fate both in the embryonic CNS and in the ocelli.

Subcellular location

Nucleus Probable.

Developmental stage

Expressed in the anterior region of the embryo before cellularization and becomes localized to the procephalic head region following gastrulation.

Domain

Contains multiple repeats consisting of single amino acids (e.g., Gly, Ser, His, and Asn) and pairs of amino acids (e.g., Gly-Val).

Sequence similarities

Belongs to the paired homeobox family.

Contains 1 homeobox DNA-binding domain.

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P22810-1)
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P22810-2)
The sequence of this isoform differs from the canonical sequence as follows:
     62-67: Missing.
     247-264: Missing.
     295-295 G → GGG
     360-361: Missing.
     599-600 LV → RVRV
Notes: No experimental confirmation available. Ref.4 (AAR88546) sequence differs from that shown due to a frameshift in position 455.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 671671Homeotic protein ocelliless

Regions

Repeat229 – 247191
Repeat248 – 266192
DNA binding73 – 13260Homeobox
Region229 – 266382 X 19 AA tandem repeats

Natural variations

Alternative sequence62 – 676Missing in isoform B.
Alternative sequence247 – 26418Missing in isoform B.
Alternative sequence2951G → GGG in isoform B.
Alternative sequence360 – 3612Missing in isoform B.
Alternative sequence599 – 6002LV → RVRV in isoform B.

Experimental info

Sequence conflict5531W → C in AAR88546. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: 515B69536E0E9B44

FASTA67169,666
        10         20         30         40         50         60 
MAAGFLKSGD LGPHPHSYGG PHPHHSVPHG PLPPGMPMPS LGPFGLPHGL EAVGFSQGMW 

        70         80         90        100        110        120 
GDLCYPGVNT RKQRRERTTF TRAQLDVLEA LFGKTRYPDI FMREEVALKI NLPESRVQVW 

       130        140        150        160        170        180 
FKNRRAKCRQ QLQQQQQSNS LSSSKNASGG GSGNSCSSSS ANSRSNSNNN GSSSNNNTQS 

       190        200        210        220        230        240 
SGGNNSNKSS QKQGNSQSSQ QGGGSSGGNN SNNNSAAAAA SAAAAVAAAQ SIKTHHSSFL 

       250        260        270        280        290        300 
SAAAAASAQS IKTHHSSFLS AAAAASGGTN QSANNNSNNN NQGNSTPNSS SSGGGSQAGG 

       310        320        330        340        350        360 
HLSAAAAAAA LNVTAAHQNS SPLLPTPATS VSPVSIVCKK EHLSGGYGSS VGGGGGGGGG 

       370        380        390        400        410        420 
GASSGGLNLG VGVGVGVGVG VGVSQDLLRS PYDQLKDAGG DIGAGVHHHH SIYGSAAGSN 

       430        440        450        460        470        480 
PRLLQPGGNI TPMDSSSSIT TPSPPITPMS PQSAPQRPMP PNRPSPPTIL PPIRPPICPI 

       490        500        510        520        530        540 
MIRITSGTIS TSNIRITMPR RPATTHRWST LAIRIRSTTT WAIRATRPPI LVCRHRHPSR 

       550        560        570        580        590        600 
APCPRRPSPR TAWITCRRRI STRIWCRIYS SNTAAVAATT TVQRGQVVRV RVRVRVRVLV 

       610        620        630        640        650        660 
LVVDLVLVLV LVLDRGAIVL PSWSSTIISS TSTSYSSISI TRIITRINTR ITTAIIIISS 

       670 
NTIMMMNSDR I

« Hide

Isoform B [UniParc].

Checksum: 188D32F28D28E732
Show »

64967,520

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References

« Hide 'large scale' references
[1]"The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures."
Finkelstein R., Smouse D., Capaci T.M., Spradling A.C., Perrimon N.
Genes Dev. 4:1516-1527(1990) [PubMed: 1979296] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM A), FUNCTION, DEVELOPMENTAL STAGE.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A. expand/collapse author list , Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
Strain: Berkeley.
Tissue: Embryo.

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Cross-references

Sequence databases

X58983 mRNA. Translation: CAA41732.1.
AE014298 Genomic DNA. Translation: AAF46400.3.
BT011185 mRNA. Translation: AAR88546.1. Frameshift.
PIRA35912.
RefSeqNP_511091.3.
UniGeneDm.2933

3D structure databases

HSSPHSSP built from PDB template 1FJL based on UniProtKB P06601.
SMRP22810. Positions 67-129.
ModBaseSearch...

Genome annotation databases

GeneID31802.

Organism-specific databases

FlyBaseFBgn0004102. oc.

Family and domain databases

InterProIPR001356. Homeobox.
IPR012287. Homeodomain-rel.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
ProDomPD000010. Homeobox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameHMOC_DROME
AccessionPrimary (citable) accession number: P22810
Secondary accession number(s): Q6NNU8, Q9W3D0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: May 20, 2008
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents