Cytochrome P450 7A1 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P22680 (CP7A1_HUMAN)

Last modified September 2, 2008. Version 83. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cytochrome P450 7A1
    EC=1.14.13.17
Alternative name(s):
    CYPVII
    Cholesterol 7-alpha-monooxygenase
    Cholesterol 7-alpha-hydroxylase

Gene names

Name:	CYP7A1
Synonyms:	CYP7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Catalytic activity	Cholesterol + NADPH + O(2) = 7-alpha-hydroxycholesterol + NADP(+) + H(2)O.
Cofactor	Heme group By similarity.
Pathway	Lipid metabolism; bile acid biosynthesis.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Sequence similarities	Belongs to the cytochrome P450 family.

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Ontologies

Keywords
Biological process	Cholesterol metabolism Lipid metabolism Steroid metabolism
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Polymorphism
Ligand	Heme Iron Metal-binding NADP
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Ref.2 Inferred from Experiment. Source: Reactome
Molecular function	cholesterol 7-alpha-monooxygenase activity Ref.2 Inferred from Experiment. Source: Reactome
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Chain

1 – 504

504

Cytochrome P450 7A1

Sites

Metal binding

444

Iron (heme axial ligand) By similarity

Natural variations

Natural variant

Natural variant

Natural variant

Experimental info

Sequence conflict

385

D → S in CAA39568. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

P22680-1 [UniParc].

Last modified June 1, 1994. Version 2.
Checksum: D8067E0FF6342949
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FASTA

504

57,661

        10         20         30         40         50         60 
MMTTSLIWGI AIAACCCLWL ILGIRRRQTG EPPLENGLIP YLGCALQFGA NPLEFLRANQ 

        70         80         90        100        110        120 
RKHGHVFTCK LMGKYVHFIT NPLSYHKVLC HGKYFDWKKF HFATSAKAFG HRSIDPMDGN 

       130        140        150        160        170        180 
TTENINDTFI KTLQGHALNS LTESMMENLQ RIMRPPVSSN SKTAAWVTEG MYSFCYRVMF 

       190        200        210        220        230        240 
EAGYLTIFGR DLTRRDTQKA HILNNLDNFK QFDKVFPALV AGLPIHMFRT AHNAREKLAE 

       250        260        270        280        290        300 
SLRHENLQKR ESISELISLR MFLNDTLSTF DDLEKAKTHL VVLWASQANT IPATFWSLFQ 

       310        320        330        340        350        360 
MIRNPEAMKA ATEEVKRTLE NAGQKVSLEG NPICLSQAEL NDLPVLDSII KESLRLSSAS 

       370        380        390        400        410        420 
LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPEI YPDPLTFKYD RYLDENGKTK 

       430        440        450        460        470        480 
TTFYCNGLKL KYYYMPFGSG ATICPGRLFA IHEIKQFLIL MLSYFELELI EGQAKCPPLD 

       490        500 
QSRAGLGILP PLNDIEFKYK FKHL

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure of the gene encoding human liver cholesterol 7 alpha-hydroxylase." Nishimoto M., Noshiro M., Okuda K. Biochim. Biophys. Acta 1172:147-150(1993) [PubMed: 8439551] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase." Noshiro M., Okuda K. FEBS Lett. 268:137-140(1990) [PubMed: 2384150] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-347.
[3]	"Polymorphisms of human cholesterol 7 alpha-hydroxylase." Karam W.G., Chiang J.Y. Biochem. Biophys. Res. Commun. 185:588-595(1992) [PubMed: 1610352] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-100.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[5]	"Structure and nucleotide sequences of the human cholesterol 7 alpha-hydroxylase gene (CYP7)." Wang D.P., Chiang J.Y. Genomics 20:320-323(1994) [PubMed: 8020987] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-140. Tissue: Placenta.
[6]	"Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene." Molowa D.T., Chen W.S., Cimis G.M., Tan C.P. Biochemistry 31:2539-2544(1992) [PubMed: 1312351] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
[7]	"Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population." Saito S., Iida A., Sekine A., Kawauchi S., Higuchi S., Ogawa C., Nakamura Y. J. Hum. Genet. 48:249-270(2003) [PubMed: 12721789] [Abstract] Cited for: VARIANTS SER-233 AND ASN-347.
+	Additional computationally mapped references.

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Web resources

Wikipedia

Cholesterol-7 alpha-hydroxylase entry

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Cross-references

Sequence databases
	X56088 mRNA. Translation: CAA39568.1. M93133 mRNA. Translation: AAA58435.1. BC101777 mRNA. Translation: AAI01778.1. BC112184 mRNA. Translation: AAI12185.1. L13460 Genomic DNA. Translation: AAA61350.1. M89647 Genomic DNA. Translation: AAA58423.1.
PIR	JH0659. S29818.
RefSeq	NP_000771.2.
UniGene	Hs.1644
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000167910. Homo sapiens. [Contig view]
GeneID	1581.
KEGG	hsa:1581.
Organism-specific databases
HGNC	HGNC:2651. CYP7A1.
HPA	HPA010970.
MIM	118455. gene.
PharmGKB	PA132.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P22680.
HOVERGEN	P22680.
Enzyme and pathway databases
Reactome	REACT_602. Lipid and lipoprotein metabolism.
Gene expression databases
ArrayExpress	P22680.
CleanEx	HS_CYP7A1.
GermOnline	ENSG00000167910. Homo sapiens.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR002403. Cyt_P450_E_grp-IV. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00465. EP450IV. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProDom	P22680. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

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Entry information

Entry name

CP7A1_HUMAN

Accession

Primary (citable) accession number: P22680
Secondary accession number(s): P78454, Q3MIL8, Q7KZ19

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1991
Last sequence update:	June 1, 1994
Last modified:	September 2, 2008
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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