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Reviewed, UniProtKB/Swiss-Prot P22443 (CP19A_RAT)

Last modified September 2, 2008. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthetase
    P-450AROM
Gene names
Name: Cyp19a1
Synonyms: Arom, Cyp19
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 508508Cytochrome P450 19A1

Sites

Metal binding4371Iron (heme axial ligand)

Experimental info

Sequence conflict3 – 42LE → FQ Ref.2
Sequence conflict101H → Q Ref.2
Sequence conflict881W → C Ref.2
Sequence conflict1011S → L Ref.2
Sequence conflict123 – 1297QCIGMHE → VVHGHAR Ref.2
Sequence conflict1881V → L Ref.2
Sequence conflict2101E → G Ref.2
Sequence conflict328 – 3314VETA → WKQ Ref.2
Sequence conflict3421D → A Ref.2
Sequence conflict364 – 3696LRYQPV → CGISPF Ref.2
Sequence conflict4221V → L Ref.2
Sequence conflict4251R → T Ref.2
Sequence conflict4491V → I Ref.2
Sequence conflict4661R → K Ref.2
Sequence conflict493 – 4975RHIFN → SPRNS Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P22443-1 [UniParc].

Last modified August 1, 1991. Version 1.
Checksum: C0ADFB0FD80AB352

FASTA50858,412
        10         20         30         40         50         60 
MFLEMLNPMH YNVTIMVPET VPVSAMPLLL IMGLLLLIRN CESSSSIPGP GYCLGIGPLI 

        70         80         90        100        110        120 
SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS SSMVHVMKHS NYISRFGSKR 

       130        140        150        160        170        180 
GLQCIGMHEN GIIFNNNPSL WRTVRPFFMK ALTGPGLIRM VEVCVESIKQ HLDRLGDVTD 

       190        200        210        220        230        240 
NSGYVDVVTL MRHIMLDTSN TLFLGIPLDE SSIVKKIQGY FNAWQALLIK PNIFFKISWL 

       250        260        270        280        290        300 
YRKYERSVKD LKDEIEILVE KKRQKVSSAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI 

       310        320        330        340        350        360 
LEMLIAAPDT MSVTLYVMLL LIAEYPEVET AILKEIHTVV GDRDIRIGDV QNLKVVENFI 

       370        380        390        400        410        420 
NESLRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR MHRLEYFPKP NEFTLENFEK 

       430        440        450        460        470        480 
NVPYRYFQPF GFGPRSCAGK YIAMVMMKVV LVTLLKRFHV KTLQKRCIEN MPKNNDLSLH 

       490        500 
LDEDSPIVEI IFRHIFNTPF LQCLYISL

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References

[1]"Aromatase cytochrome P450 in rat ovarian granulosa cells before and after luteinization: adenosine 3',5'-monophosphate-dependent and independent regulation. Cloning and sequencing of rat aromatase cDNA and 5' genomic DNA."
Hickey G.J., Krasnow J.S., Beattie W.G., Richards J.S.
Mol. Endocrinol. 4:3-12(1990) [PubMed: 2157976] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]"The structure of cDNA clones encoding the aromatase P-450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line."
Lephart E.D., Peterson K.G., Noble J.F., George F.W., McPhaul M.J.
Mol. Cell. Endocrinol. 70:31-40(1990) [PubMed: 2340950] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

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Cross-references

Sequence databases

M33986 mRNA. Translation: AAA41044.1.
PIRA36121.
UniGeneRn.21402

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000000196. Rattus norvegicus. [Contig view]

Organism-specific databases

RGD2457. Cyp19a1.

Phylogenomic databases

HOVERGENP22443.

Gene expression databases

ArrayExpressP22443.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP22443.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameCP19A_RAT
AccessionPrimary (citable) accession number: P22443
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: August 1, 1991
Last modified: September 2, 2008
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents