Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot P19098 (CP19A_CHICK)

Last modified September 2, 2008. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthetase
    P-450AROM
Gene names
Name: CYP19A1
Synonyms: AROM, CYP19
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Hide | Top

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Hide | Top

Ontologies

Keywords

   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

None. [Check GOA]

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 507507Cytochrome P450 19A1

Sites

Metal binding4361Iron (heme axial ligand)

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P19098-1 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: DDDC1EF7AEC1577F

FASTA50758,146
        10         20         30         40         50         60 
MIPETLNPLN YFTSLVPDLM PVATVPIIIL ICFLFLIWNH EETSSIPGPG YCMGIGPLIS 

        70         80         90        100        110        120 
HGRFLWMGVG NACNYYNKTY GEFVRVWISG EETFIISKSS SVFHVMKHWN YVSRFGSKLG 

       130        140        150        160        170        180 
LQCIGMYENG IIFNNNPAHW KEIRPFFTKA LSGPGLVRMI AICVESTIVH LDKLEEVTTE 

       190        200        210        220        230        240 
VGNVNVLNLM RRIMLDTSNK LFLGVPLDES AIVLKIQNYF DAWQALLLKP DIFFKISWLC 

       250        260        270        280        290        300 
KKYEEAAKDL KGAMEILIEQ KRQKLSTVEK LDEHMDFASQ LIFAQNRGDL TAENVNQCVL 

       310        320        330        340        350        360 
EMMIAAPDTL SVTLFIMLIL IADDPTVEEK MMREIETVMG DREVQSDDMP NLKIVENFIY 

       370        380        390        400        410        420 
ESMRYQPVVD LIMRKALQDD VIDGYPVKKG TNIILNIGRM HKLEFFPKPN EFSLENFEKN 

       430        440        450        460        470        480 
VPSRYFQPFG FGPRGCVGKF IAMVMMKAIL VTLLRRCRVQ TMKGRGLNNI QKNNDLSMHP 

       490        500 
IERQPLLEMV FTQEAQTRIR VTKVDQH

« Hide

Hide | Top

References

[1]"The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen."
McPhaul M.J., Noble J.F., Simpson E.R., Mendelson C.R., Wilson J.D.
J. Biol. Chem. 263:16358-16363(1988) [PubMed: 3182796] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.
[2]"Comparison of 5' upstream regions of chicken and quail aromatase genes."
Kudo T., Yamamoto H., Sato S., Sutou S.
J. Reprod. Dev. 42:101-107(1996)
Cited for: NUCLEOTIDE SEQUENCE OF 1-47.
Strain: Leghorn.
Tissue: Liver.

Hide | Top

Cross-references

Sequence databases

J04047 mRNA. Translation: AAA48738.1.
J04047 mRNA. Translation: AAA48739.1. Different initiation.
D50335 Genomic DNA. Translation: BAA08871.1.
PIRA31916.
RefSeqNP_001001761.1.
UniGeneGga.859

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSGALG00000013294. Gallus gallus. [Contig view]
GeneID414854.
KEGGgga:414854.

Phylogenomic databases

HOGENOMP19098.
HOVERGENP19098.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP19098.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

Hide | Top

Entry information

Entry nameCP19A_CHICK
AccessionPrimary (citable) accession number: P19098
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 2, 2008
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents