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Reviewed, UniProtKB/Swiss-Prot P16423 (POLR_DROME)

Last modified November 25, 2008. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM
Alternative name(s):
    Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM
Including the following 3 domains:
    1- Recommended name:
            Protease
              EC=3.4.23.-
    2- Recommended name:
            Reverse transcriptase
              EC=2.7.7.49
    3- Recommended name:
            Endonuclease
Gene names
Name: pol
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length1057 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existencePredicted.

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General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Sequence similarities

Contains 1 C2H2-type zinc finger.

Contains 1 reverse transcriptase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10571057Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM
PRO_0000058511

Regions

Domain384 – 660277Reverse transcriptase
Zinc finger61 – 8424C2H2-type

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Sequences

Sequence LengthMass (Da)Tools
P16423-1 [UniParc].

Last modified August 1, 1990. Version 1.
Checksum: 64989B5E215CD2AF

FASTA1,057120,041
        10         20         30         40         50         60 
FERKNFSDGL VPQRKFIHIG TTSTNNEPRI PLHNLMTTRP SVDIFPEDQY EPNAAATLSR 

        70         80         90        100        110        120 
VPCTVCGRSF NSKRGLGVHM RSRHPDELDE ERRRVDIKAR WSDEEKWMMA RKEVELTANG 

       130        140        150        160        170        180 
CKHINKQLAV YFANRSVEAI KKLRQRGDYK EKIEQIRGQS ALAPEVANLT IRRRPSRSEQ 

       190        200        210        220        230        240 
DHQVTTSETT PITPFEQSNR EILRTLRGYS PVECHSKWRA QELQTIIDRA HLEGKETTLQ 

       250        260        270        280        290        300 
CLSLYLLGIF PAQGVRHTLT RPPRRPRNRR ESRRQQYAVV QRNWDKHKGR CIKSLLNGTD 

       310        320        330        340        350        360 
ESVMPSQEIM VPYWREVMTQ PSPSSCSGEV IQMDHSLERV WSAITEQDLR ASRVSLSSSP 

       370        380        390        400        410        420 
GPDGITPKSA REVPSGIMLR IMNLILWCGN LPHSIRLART VFIPKTVTAK RPQDFRPISV 

       430        440        450        460        470        480 
PSVLVRQLNA ILATRLNSSI NWDPRQRGFL PTDGCADNAT IVDLVLRHSH KHFRSCYIAN 

       490        500        510        520        530        540 
LDVSKAFDSL SHASIYDTLR AYGAPKGFVD YVQNTYEGGG TSLNGDGWSS EEFVPARGVK 

       550        560        570        580        590        600 
QGDPLSPILF NLVMDRLLRT LPSEIGAKVG NAITNAAAFA DDLVLFAETR MGLQVLLDKT 

       610        620        630        640        650        660 
LDFLSIVGLK LNADKCFTVG IKGQPKQKCT VLEAQSFYVG SSEIPSLKRT DEWKYLGINF 

       670        680        690        700        710        720 
TATGRVRCNP AEDIGPKLQR LTKAPLKPQQ RLFALRTVLI PQLYHKLALG SVAIGVLRKT 

       730        740        750        760        770        780 
DKLIRYYVRR WLNLPLDVPI AFVHAPPKSG GLGIPSLRWV APMLRLRRLS NIKWPHLTQN 

       790        800        810        820        830        840 
EVASSFLEAE KQRARDRLLA EQNELLSRPA IEKYWANKLY LSVDGSGLRE GGHYGPQHGW 

       850        860        870        880        890        900 
VSQPTRLLTG KEYMDGIRLR INALPTKSRT TRGRHELERQ CRAGCDAPET TNHIMQKCYR 

       910        920        930        940        950        960 
SHGRRVARHN CVVNRIKRGL EERGCVVIVE PSLQCESGLN KPDLVALRQN HIDVIDTQIV 

       970        980        990       1000       1010       1020 
TDGHSMDDAH QRKINRYDRP DIRTELRRRF EAAGDIEFHS ATLNWRGIWS GQSVKRLIAK 

      1030       1040       1050 
GLLSKYDSHI ISVQVMRGSL GCFKQFMYLS GFSRDWT

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References

[1]"Type I (R1) and type II (R2) ribosomal DNA insertions of Drosophila melanogaster are retrotransposable elements closely related to those of Bombyx mori."
Jakubczak J.L., Xiong Y., Eickbush T.H.
J. Mol. Biol. 212:37-52(1990) [PubMed: 1690812] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Oregon-R.

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Cross-references

Sequence databases

X51967 Genomic DNA. Translation: CAA36225.1.
PIRS09112.

3D structure databases

ModBaseSearch...

Organism-specific databases

FlyBaseFBgn0016699. R2-element\ORF.

Family and domain databases

InterProIPR000477. DNA_pol_RVTase.
IPR015706. Reverse_transcriptase-related.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PANTHERPTHR19446. Rev_txptase. 1 hit.
PfamPF00078. RVT_1. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEPS50878. RT_POL. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePOLR_DROME
AccessionPrimary (citable) accession number: P16423
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 25, 2008
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents