Reviewed,
UniProtKB/Swiss-Prot P15129 (CP4B1_RAT)
Last modified
September 2, 2008.
Version 68.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Cytochrome P450 4B1 EC=1.14.14.1 Alternative name(s): CYPIVB1 P450-isozyme 5 P450 L-2 | ||||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 511 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
| Catalytic activity | RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O. |
| Cofactor | Heme group By similarity. |
| Subcellular location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Induction | P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Ligand | Heme Iron Metal-binding |
| Molecular function | Monooxygenase Oxidoreductase |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB." Gasser R., Philpot R.M. Mol. Pharmacol. 35:617-625(1989) [PubMed: 2725471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [3] | "Purification and characterization of rat pulmonary cytochrome P-450." Imaoka S., Funae Y. J. Biochem. 108:33-36(1990) [PubMed: 2229008] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-11. Tissue: Lung. |
Cross-references
Sequence databases | |
|---|---|
| M29853 mRNA. Translation: AAA41778.1. BC074012 mRNA. Translation: AAH74012.1. | |
| PIR | B40164. |
| RefSeq | NP_058695.2. |
| UniGene | Rn.86651 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1JME based on UniProtKB P14779. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSRNOG00000009741. Rattus norvegicus. [Contig view] |
| GeneID | 24307. |
| KEGG | rno:24307. |
Organism-specific databases | |
| RGD | 2480. Cyp4b1. |
Phylogenomic databases | |
| HOVERGEN | P15129. |
Gene expression databases | |
| ArrayExpress | P15129. |
| GermOnline | ENSRNOG00000009741. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR001128. Cyt_P450. IPR002401. Cyt_P450_E_grp-I. [Graphical view] |
| Gene3D | G3DSA:1.10.630.10. Cyt_P450. 1 hit. |
| PANTHER | PTHR19383. Cyt_P450. 1 hit. |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PRINTS | PR00463. EP450I. PR00385. P450. |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProDom | P15129. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | CP4B1_RAT | ||||||||
| Accession | Primary (citable) accession number: P15129 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
