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Reviewed, UniProtKB/Swiss-Prot P15123 (CP2CG_RABIT)

Last modified November 25, 2008. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 2C16
    EC=1.14.14.1
Alternative name(s):
    CYPIIC16
Gene names
Name: CYP2C16
OrganismOryctolagus cuniculus (Rabbit)
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

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Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Expressed constitutively in liver, lung, testes, and kidney.

Induction

By phenobarbital in each tissue with the exception of the kidney.

Sequence similarities

Belongs to the cytochrome P450 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487Cytochrome P450 2C16
PRO_0000051706

Sites

Metal binding4321Iron (heme axial ligand)

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Sequences

Sequence LengthMass (Da)Tools
P15123-1 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: F282245DA3CB90A2

FASTA48755,542
        10         20         30         40         50         60 
MDPVVVLVLG LCCLLLLSHW KQNSGRGKLP PGPTPFPIIG NILQIDAKDI SKSLTKFSER 

        70         80         90        100        110        120 
YGPVFTVYLG MKPAVVLHGY QAVKEALVDL GEEFAGRGSF PMLDKVSKGL GIVFTNGKRW 

       130        140        150        160        170        180 
KEIRRFSLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTN ASPCDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
IIFHNRFDYK DEEFLKLLEK FNENVRILSS PWLQVCNNFP ALIDYLPGSH KTLLKNSDYV 

       250        260        270        280        290        300 
KNFIMEKVKE HQKFLDVNNP RDFIDCFLIK MEQENHLEFT LESLVTTVFD LFGAGTETTS 

       310        320        330        340        350        360 
TTLRYSLLLL LKHPEVADKV QEEIERVIGR HRSPCMQDRS RMPYTDAVIH EIQRFIDLVP 

       370        380        390        400        410        420 
NNLPHTVTRD IKFRNYFIPK GTDIMTSLTS VLHDEKAFPN PKVFDPGHFL DESGNFKKSD 

       430        440        450        460        470        480 
YFMPFSAGKR ICVGEALARM ELFLFLTSIL QNFKLQSLVE PKDLDITAVL NGFVSVPPSF 


QLCFIPV

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References

[1]"Sequence and gene expression of rabbit cytochrome P450 IIC16: comparison to highly related family members."
Hassett C., Omiecinski C.J.
Nucleic Acids Res. 18:1429-1434(1990) [PubMed: 2326187] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Use of a conserved consensus oligomer in the identification of cytochrome P-450 mRNAs."
Hassett C., Omiecinski C.J.
Biochem. Biophys. Res. Commun. 149:326-333(1987) [PubMed: 3426576] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 414-487.

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Cross-references

Sequence databases

M29661 mRNA. Translation: AAA31227.1.
M29968 mRNA. Translation: AAA31226.1.
M18376 mRNA. Translation: AAA31215.1.
PIRO4RBC6. S12765.

3D structure databases

HSSPHSSP built from PDB template 1DT6 based on UniProtKB P00179.
SMRP15123. Positions 44-487.
ModBaseSearch...

Genome annotation databases

EnsemblENSOCUG00000015330. Oryctolagus cuniculus. [Contig view]

Phylogenomic databases

HOVERGENP15123.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCP2CG_RABIT
AccessionPrimary (citable) accession number: P15123
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 25, 2008
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents