Skip Header

 
Contribute Send feedback

Reviewed, UniProtKB/Swiss-Prot P15021 (STEL5_DROME)

Last modified July 22, 2008. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Stellate protein CG33240/CG33245
Gene names
Name: Ste:CG33240
ORF Names: CG33240
AND
Name: Ste:CG33245
ORF Names: CG33245
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Hide | Top

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

Unknown. In males lacking the Y chromosome, its strong overexpression leads to the appearance of proteinaceous star-shaped crystals in the primary spermatocytes causing meiotic drive, possibly by interfering with normal casein kinase 2 activity.

Subunit structure

Interacts in vitro with the casein kinase 2 alpha subunit (CkII-alpha). The relevance of such interaction is however unclear in vivo.

Tissue specificity

Probably not expressed in wild-type flies. In males lacking the Y chromosome, it is testis-specific and constitutes the main component of star-shaped crystals.

Induction

In wild-type flies, it is strongly down-regulated by double-stranded RNA (dsRNA) interference mediated by Su(Ste) transcripts. In males lacking the Y chromosome, the absence of Su(Ste) locus, relieves such down-regulation, explaining why it is strongly expressed.

Miscellaneous

There are multiple copies of the stellate gene in fruit fly, encoding proteins that are extremely similar, which gives their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members.

Sequence similarities

Belongs to the casein kinase 2 subunit beta family.

Hide | Top

Ontologies

Keywords

   Technical termComplete proteome

Gene Ontology (GO)

   Biological processspermatogenesis Ref.1

Inferred from genetic interaction. Source: FlyBase

   Cellular componentcytoplasm Ref.4

Inferred from direct assay. Source: FlyBase

nucleus Ref.4

Inferred from direct assay. Source: FlyBase

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 172172Stellate protein CG33240/CG33245

Experimental info

Sequence conflict1591M → L in CAA33906. Ref.1
Sequence conflict1721Missing in AAS65329. Ref.2

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P15021-1 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: C86304F591E62A8A

FASTA17219,525
        10         20         30         40         50         60 
MSSSQNNNSS WIDWFLGIKG NQFLCRVPTD YVQDTFNQMG LEYFSEILDV ILKPVIDSSS 

        70         80         90        100        110        120 
GLLYGDEKKW YGMIHARYIR SERGLIAMHR KYLRGDFGSC PNISCDRQNT LPVGLSAVWG 

       130        140        150        160        170 
KSTVKIHCPR CKSNFHPKSD TQLDGAMFGP SFPDIFFSML PNLTSPLDDP RT

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"Detailed structure of the Drosophila melanogaster stellate genes and their transcripts."
Livak K.J.
Genetics 124:303-316(1990) [PubMed: 1689686] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Oregon-R.
Tissue: Testis.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2."
Bozzetti M.P., Massari S., Finelli P., Meggio F., Pinna L.A., Boldyreff B., Issinger O.G., Palumbo G., Ciriaco C., Bonaccorsi S., Pimpinelli S.
Proc. Natl. Acad. Sci. U.S.A. 92:6067-6071(1995) [PubMed: 7597082] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH CKII-ALPHA.
[5]"A role of the Drosophila homeless gene in repression of Stellate in male meiosis."
Stapleton W., Das S., McKee B.D.
Chromosoma 110:228-240(2001) [PubMed: 11513298] [Abstract]
Cited for: INDUCTION.
[6]"Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline."
Aravin A.A., Naumova N.M., Tulin A.V., Vagin V.V., Rozovsky Y.M., Gvozdev V.A.
Curr. Biol. 11:1017-1027(2001) [PubMed: 11470406] [Abstract]
Cited for: INDUCTION.

Hide | Top

Cross-references

Sequence databases

X15899 Genomic DNA. Translation: CAA33906.1.
AE014298 Genomic DNA. Translation: AAS65329.1.
AE014298 Genomic DNA. Translation: AAS65334.1.
PIRS24397.
RefSeqNP_996423.1.
NP_996428.1.

3D structure databases

HSSPHSSP built from PDB template 1QF8 based on UniProtKB P13862.
ModBaseSearch...

Genome annotation databases

EnsemblCG33236. Drosophila melanogaster. [Contig view]
CG33240. Drosophila melanogaster. [Contig view]
CG33244. Drosophila melanogaster. [Contig view]
CG33245. Drosophila melanogaster. [Contig view]
GeneID2768900.
2768906.
KEGGdme:Dmel_CG33240.
dme:Dmel_CG33245.

Organism-specific databases

FlyBaseFBgn0053240. Ste:CG33240.
FBgn0053245. Ste:CG33245.

Phylogenomic databases

HOGENOMP15021.

Gene expression databases

GermOnlineCG33236. Drosophila melanogaster.
CG33240. Drosophila melanogaster.
CG33244. Drosophila melanogaster.
CG33245. Drosophila melanogaster.

Family and domain databases

InterProIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
Gene3DG3DSA:1.10.1820.10. Casein_kin_II_reg-sub_a-hlx. 1 hit.
G3DSA:2.20.25.20. Casein_kin_II_reg-sub_b-sht. 1 hit.
PANTHERPTHR11740. CAS_kinase_II. 1 hit.
PfamPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSPR00472. CASNKINASEII.
ProDomPD003829. CAS_kinase_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS01101. CK2_BETA. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

Hide | Top

Entry information

Entry nameSTEL5_DROME
AccessionPrimary (citable) accession number: P15021
Secondary accession number(s): Q7KV16
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 5, 2005
Last modified: July 22, 2008
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

Hide | Top

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents