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Reviewed, UniProtKB/Swiss-Prot P13584 (CP4B1_HUMAN)

Last modified July 22, 2008. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 4B1
    EC=1.14.14.1
Alternative name(s):
    CYPIVB1
    P450-HP
Gene names
Name: CYP4B1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   Coding sequence diversityPolymorphism
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

   Molecular functionoxygen binding Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 511511Cytochrome P450 4B1

Sites

Metal binding4531Iron (heme axial ligand)
Binding site3151Heme (covalent; via 1 link) By similarity

Natural variations

Natural variant1731R → W in allele CYP4B1*3 and allele CYP4B1*6.
Natural variant3221S → G in allele CYP4B1*4.
Natural variant3311M → I in allele CYP4B1*2, allele CYP4B1*7 and allele CYP4B1*5.
Natural variant3401R → C in allele CYP4B1*2 and allele CYP4B1*7.
Natural variant3451V → I in allele CYP4B1*6.
Natural variant3751R → C in allele CYP4B1*2.

Experimental info

Sequence conflict371Q → R in AAA35712. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P13584-1 [UniParc].

Last modified June 7, 2004. Version 2.
Checksum: 91FED40949507EB8

FASTA51158,991
        10         20         30         40         50         60 
MVPSFLSLSF SSLGLWASGL ILVLGFLKLI HLLLRRQTLA KAMDKFPGPP THWLFGHALE 

        70         80         90        100        110        120 
IQETGSLDKV VSWAHQFPYA HPLWFGQFIG FLNIYEPDYA KAVYSRGDPK APDVYDFFLQ 

       130        140        150        160        170        180 
WIGRGLLVLE GPKWLQHRKL LTPGFHYDVL KPYVAVFTES TRIMLDKWEE KAREGKSFDI 

       190        200        210        220        230        240 
FCDVGHMALN TLMKCTFGRG DTGLGHRDSS YYLAVSDLTL LMQQRLVSFQ YHNDFIYWLT 

       250        260        270        280        290        300 
PHGRRFLRAC QVAHDHTDQV IRERKAALQD EKVRKKIQNR RHLDFLDILL GARDEDDIKL 

       310        320        330        340        350        360 
SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPEHQHR CREEVREILG DQDFFQWDDL 

       370        380        390        400        410        420 
GKMTYLTMCI KESFRLYPPV PQVYRQLSKP VTFVDGRSLP AGSLISMHIY ALHRNSAVWP 

       430        440        450        460        470        480 
DPEVFDSLRF STENASKRHP FAFMPFSAGP RNCIGQQFAM SEMKVVTAMC LLRFEFSLDP 

       490        500        510 
SRLPIKMPQL VLRSKNGFHL HLKPLGPGSG K

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References

[1]"Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping."
Nhamburo P.T., Gonzalez F.J., McBride O.W., Gelboin H.V., Kimura S.
Biochemistry 28:8060-8066(1989) [PubMed: 2574990] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression."
Yokotani N., Sogawa K., Matsubara S., Gotoh O., Kusunose E., Kusunose M., Fujii-Kuriyama Y.
Eur. J. Biochem. 187:23-29(1990) [PubMed: 2298205] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[3]"Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant."
Lo-Guidice J.-M., Allorge D., Cauffiez C., Chevalier D., Lafitte J.-J., Lhermitte M., Broly F.
Pharmacogenetics 12:367-374(2002) [PubMed: 12142726] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS TRP-173; GLY-322; ILE-331; CYS-340 AND CYS-375.
+Additional computationally mapped references.

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Cross-references

Sequence databases

J02871 mRNA. Translation: AAA35712.1.
X16699 mRNA. Translation: CAA34672.1.
AF491285 mRNA. Translation: AAM09532.1.
AY064485 mRNA. Translation: AAL57720.1.
AY064486 mRNA. Translation: AAL57721.1.
PIRO4HUB1. S07765.
RefSeqNP_000770.2.
UniGeneHs.436317

3D structure databases

HSSPHSSP built from PDB template 1JME based on UniProtKB P14779.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000142973. Homo sapiens. [Contig view]
GeneID1580.
KEGGhsa:1580.

Organism-specific databases

H-InvDBHIX0000556.
HGNCHGNC:2644. CYP4B1.
HPAHPA004331.
MIM124075. gene.
PharmGKBPA27119.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENP13584.

Gene expression databases

ArrayExpressP13584.
CleanExHS_CYP4B1.
GermOnlineENSG00000142973. Homo sapiens.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP13584.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameCP4B1_HUMAN
AccessionPrimary (citable) accession number: P13584
Secondary accession number(s): Q8TD85, Q8WWU9, Q8WWV0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 7, 2004
Last modified: July 22, 2008
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents