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Reviewed, UniProtKB/Swiss-Prot P13054 (KNRL_DROME)

Last modified July 22, 2008. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Knirps-related protein
Alternative name(s):
    Nuclear receptor subfamily 0 group A member 2
Gene names
Name: knrl
Synonyms: NR0A2
ORF Names: CG4761
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length647 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Nucleus.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR0 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

CtBPO460361EBI-134637,EBI-159330
G-oalpha47AP16378-21EBI-134637,EBI-197479

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 647647Knirps-related protein

Regions

DNA binding11 – 8777Nuclear receptor
Zinc finger14 – 3421NR C4-type
Zinc finger51 – 7525NR C4-type
Compositional bias121 – 262142Gly-rich
Compositional bias577 – 59721Asn-rich

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Sequences

Sequence LengthMass (Da)Tools
P13054-1 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: E466FA081DAACDC8

FASTA64768,322
        10         20         30         40         50         60 
MMNQDNPYAM NQTCKVCGEP AAGFHFGAFT CEGCKSFFGR SYNNLSSISD CKNNGECIIN 

        70         80         90        100        110        120 
KKNRTACKAC RLKKCLMVGM SKSGSRYGRR SNWFKIHCLL QEQQQQAVAA MAAHHNSQQA 

       130        140        150        160        170        180 
GGGSSGGSGG GQGMPNGVKG MSGVPPPAAA AAALGMLGHP GGYPGLYAVA NAGGSSRSKE 

       190        200        210        220        230        240 
ELMMLGLDGS VEYGSHKHPV VASPSVSSPD SHNSDSSVEV SSVRGNPLLH LGGKSNSGGS 

       250        260        270        280        290        300 
SSGADGSHSG GGGGGGGGVT PGRPPQMRKD LSPFLPLPFP GLASMPVMPP PAFLPPSHLL 

       310        320        330        340        350        360 
FPGYHPALYS HHQGLLKPTP EQQQAAVAAA AVQHLFNSSG AGQRFAPGTS PFANHQQHHK 

       370        380        390        400        410        420 
EEDQPAPARS PSTHANNNHL LTNGGAADEL TKRFYLDAVL KSQQQSPPPT TKLPPHSKQD 

       430        440        450        460        470        480 
YSISALVTPN SESGRERVKS RQNEEDDEAR ADGIIDGAEH DDEEEDLVVS MTPPHSPAQQ 

       490        500        510        520        530        540 
EERTPAGEDP RPSPGQDNPI DLSMKTTGSS LSSKSSSPEI EPETEISSDV EKNDTDDDDE 

       550        560        570        580        590        600 
DLKVTPEEEI SVRETADPEI EEDHSSTTET AKTSIENTHN NNNSISNNNN NNNNNNNSIL 

       610        620        630        640 
SDSEASETIK RKLDELIEAS SENGKRLRLE APVKVATSNA LDLTTKV

« Hide

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References

« Hide 'large scale' references
[1]"The Drosophila gene knirps-related is a member of the steroid-receptor gene superfamily."
Oro A.E., Ong E.S., Margolis J.S., Posakony J.W., McKeown M., Evans R.M.
Nature 336:493-496(1988) [PubMed: 2848202] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.

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Cross-references

Sequence databases

X14153 Genomic DNA. Translation: CAA32365.1.
AE014296 Genomic DNA. Translation: AAF51627.2.
AY075383 mRNA. Translation: AAL68221.1.
PIRS06450.
RefSeqNP_788552.1.
UniGeneDm.1017

3D structure databases

HSSPHSSP built from PDB template 1KB2 based on UniProtKB P11473.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:20216N.
IntActP13054.

Genome annotation databases

EnsemblCG4761. Drosophila melanogaster. [Contig view]
GeneID40285.
KEGGdme:Dmel_CG4761.
NMPDRfig|7227.3.peg.10785.

Organism-specific databases

FlyBaseFBgn0001323. knrl.

Phylogenomic databases

HOGENOMP13054.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-017588-MON.

Gene expression databases

ArrayExpressP13054.
GermOnlineCG4761. Drosophila melanogaster.

Family and domain databases

InterProIPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
Gene3DG3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
PfamPF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR00047. STROIDFINGER.
PR00350. VITAMINDR.
ProDomPD000035. Znf_C4steroid. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00399. ZnF_C4. 1 hit.
[Graphical view]
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameKNRL_DROME
AccessionPrimary (citable) accession number: P13054
Secondary accession number(s): Q9VPC8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 22, 2008
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents