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Reviewed, UniProtKB/Swiss-Prot P12613 (TCPA_DROME)

Last modified November 4, 2008. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    T-complex protein 1 subunit alpha
      Short name=TCP-1-alpha
Alternative name(s):
    CCT-alpha
Gene names
Name: T-cp1
Synonyms: CCT-1, Tcp-1
ORF Names: CG5374
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Molecular chaperone; assist the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

Subunit structure

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the TCP-1 chaperonin family.

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Ontologies

Keywords

   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processmitotic spindle organization

Inferred from mutant phenotype. Source: FlyBase

phagocytosis, engulfment

Inferred from mutant phenotype. Source: FlyBase

   Cellular componentmitochondrial proton-transporting ATP synthase complex

Non-traceable author statement. Source: FlyBase

   Molecular functionhydrogen-exporting ATPase activity, phosphorylative mechanism

Non-traceable author statement. Source: FlyBase

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557T-complex protein 1 subunit alpha
PRO_0000128310

Experimental info

Sequence conflict17 – 193GAS → RRI in AAA28927. Ref.1
Sequence conflict1921A → V in AAA28927. Ref.1
Sequence conflict1981I → V in AAA28927. Ref.1
Sequence conflict2401L → H in AAA28927. Ref.1
Sequence conflict4131A → R in AAA28927. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P12613-1 [UniParc].

Last modified May 4, 2001. Version 2.
Checksum: 6F4A28237456F3A2

FASTA55759,557
        10         20         30         40         50         60 
MSTLASPLSI AGTRQSGASV RTQNVMAALS ISNIVKSSLG PVGLDKMLVD DIGDVTVTND 

        70         80         90        100        110        120 
GATILRLLEV EHPAAKVLVE LAQLQDEEVG DGTTSVVILA AELLKNADEL VKQKIHPTSI 

       130        140        150        160        170        180 
ISGYRIACKE ACKYISEHLT APVDELGRDS LINIAKTSMS SKIIGADAEF FSAMVVDAAQ 

       190        200        210        220        230        240 
SVKITDPRGQ AAYSIKAINV LKAHGKSARE SVLIPGYALN CTIASQQMPK KIVNAKIACL 

       250        260        270        280        290        300 
DFSLQKTKMK MGVQVLINDP DKLEAIRARE LDITKERINM ILGTGVNVVL VSGGVDDLCM 

       310        320        330        340        350        360 
KYFVEAGAMA VRRVKKSDLK IIAKATGAAF ITSLTNMDGE ESFDASMVGE AAEVAQERIC 

       370        380        390        400        410        420 
DDELILIKGT KARAAASIIL RGPNDFYCDE MERSVHDALC VVKRVLESKK VVAGGGCVEA 

       430        440        450        460        470        480 
ALSIYLENFA TSLASREQLA IAEFAKSLLV IPKTLSVNAA KDATDLVAKL RSYHNSSQTK 

       490        500        510        520        530        540 
PERSDLKWTG LDLIEGVVRD NKKAGVLEPA MSKIKSLKFA TEAAITILRI DDMIKLNPED 

       550 
KSGKSYADAC AAGELDG

« Hide

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References

« Hide 'large scale' references
[1]"A Drosophila melanogaster gene encodes a protein homologous to the mouse t complex polypeptide 1."
Ursic D., Ganetzky B.
Gene 68:267-274(1988) [PubMed: 3146529] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.

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Cross-references

Sequence databases

M21159 mRNA. Translation: AAA28927.1.
AE014297 Genomic DNA. Translation: AAF56009.1.
AY118416 mRNA. Translation: AAM48445.1.
PIRJT0367.
RefSeqNP_524450.2.
NP_732748.1.
UniGeneDm.1279

3D structure databases

HSSPHSSP built from PDB template 1A6D based on UniProtKB P48424.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:22081N.
IntActP12613.

Genome annotation databases

EnsemblCG5374. Drosophila melanogaster. [Contig view]
GeneID42649.
KEGGdme:Dmel_CG5374.

Organism-specific databases

FlyBaseFBgn0003676. T-cp1.

Phylogenomic databases

HOGENOMP12613.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-012831-MON.
DMEL-XXX-02:DMEL-XXX-02-012832-MON.

Gene expression databases

ArrayExpressP12613.
GermOnlineCG5374. Drosophila melanogaster.

Family and domain databases

InterProIPR012715. Chap_CCT_alpha.
IPR002194. Chaperonin_TCP-1_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
[Graphical view]
PANTHERPTHR11353:SF20. Chap_CCT_alpha. 1 hit.
PTHR11353. Cpn60/TCP-1. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSPR00298. CHAPERONIN60.
PR00304. TCOMPLEXTCP1.
TIGRFAMsTIGR02340. chap_CCT_alpha. 1 hit.
PROSITEPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio829871.

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Entry information

Entry nameTCPA_DROME
AccessionPrimary (citable) accession number: P12613
Secondary accession number(s): Q9VCZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 4, 2001
Last modified: November 4, 2008
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents