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Reviewed, UniProtKB/Swiss-Prot P11714 (CP2D9_MOUSE)

Last modified July 22, 2008. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 2D9
    EC=1.14.14.1
Alternative name(s):
    CYPIID9
    P450-16-alpha
    CA
    Testosterone 16-alpha hydroxylase
Gene names
Name: Cyp2d9
Synonyms: Cyp2d-9
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

   Cellular componentmicrosome

Inferred from direct assay. Source: MGI

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 504504Cytochrome P450 2D9

Sites

Metal binding4461Iron (heme axial ligand)

Experimental info

Sequence conflict54 – 552LG → QD in AAA39876. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P11714-1 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: B85862205472A176

FASTA50456,949
        10         20         30         40         50         60 
MELLTGTDLW PVAIFTVIFI LLVDLTHQRQ RWTSRYPPGP VPWPVLGNLL QVDLGNMPYS 

        70         80         90        100        110        120 
LYKLQNRYGD VFSLQMAWKP MVVINGLKAM KEMLLTCGED TADRPPVPIF EYLGVKPGSQ 

       130        140        150        160        170        180 
GVVLAPYGPE WREQRRFSVS TLRNFGLGKK SLEDWVTKEA NHLCDAFTAQ AGQPINPNPM 

       190        200        210        220        230        240 
LNKSTCNVIA SLIFARRFEY EDPFLIRMLK VLEQSLTEVS GLIPEVLNAF PILLRIPRLA 

       250        260        270        280        290        300 
DKALQGQKSF IAILDNLLTE NRTTWDPVQA PRNLTDAFLA QIEKAKGNPE SSFNDENLLM 

       310        320        330        340        350        360 
VVRDLFGAGM LTTSTTLSWA LMLMILHPDV QRRVQQEIDE VIGQVRHPEM ADQAHMPYTN 

       370        380        390        400        410        420 
AVIHEVQRFG DIVPVNLPRI TSHDIEVQDF LIPKGTILLP NMSSMLKDES VWEKPLRFHP 

       430        440        450        460        470        480 
EHFLDAQGHF VKPEAFMPFS AGRRSCLGEA LARMELFLFF TCLLQRFSFS VPDGQPQPSN 

       490        500 
SGVYGILVAP SPYQLCAVVR DQGH

« Hide

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References

[1]"Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgen."
Wong G., Kawajiri K., Negishi M.
Biochemistry 26:8683-8690(1987) [PubMed: 2831949] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Functional characterization of two cytochrome P-450s within the mouse, male-specific steroid 16 alpha-hydroxylase gene family: expression in mammalian cells and chimeric proteins."
Ichikawa T., Itakura T., Negishi M.
Biochemistry 28:4779-4784(1989) [PubMed: 2788458] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/J.
Tissue: Liver.
[3]"Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16 alpha)) in mice. Organization, differential regulation, and chromosome localization."
Wong G., Itakura T., Kawajiri K., Skow L., Negishi M.
J. Biol. Chem. 264:2920-2927(1989) [PubMed: 2914938] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

M23998 mRNA. Translation: AAA40427.1.
M23997 mRNA. Translation: AAA40428.1. Sequence problems.
M27168 mRNA. Translation: AAA39876.1.
M24267, M24262 Genomic DNA. Translation: AAA75462.1.
PIRB27384.
A27384. S15806.
UniGeneMm.378904

3D structure databases

HSSPHSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000068086. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:88606. Cyp2d9.

Phylogenomic databases

HOGENOMP11714.
HOVERGENP11714.

Gene expression databases

ArrayExpressP11714.
GermOnlineENSMUSG00000068086. Mus musculus.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP11714.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameCP2D9_MOUSE
AccessionPrimary (citable) accession number: P11714
Secondary accession number(s): Q64489
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 22, 2008
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents