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Reviewed, UniProtKB/Swiss-Prot P10610 (CP2G1_RAT)

Last modified September 2, 2008. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 2G1
    EC=1.14.14.1
Alternative name(s):
    CYPIIG1
    P450-OLF1
    Olfactive
Gene names
Name: Cyp2g1
Synonyms: Cyp2g-1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. This isozyme seems to be implicated in olfaction.

Catalytic activity

RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Olfactory epithelium.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Biological processOlfaction
Sensory transduction
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

   Cellular componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 494494Cytochrome P450 2G1

Sites

Metal binding4391Iron (heme axial ligand) By similarity

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Sequences

Sequence LengthMass (Da)Tools
P10610-1 [UniParc].

Last modified July 1, 1989. Version 1.
Checksum: 8A06E256A9A48702

FASTA49456,781
        10         20         30         40         50         60 
MALGGAFSIF MTLCLSCLLI LIAWKRTSRG GKLPPGPTPI PFLGNLLQVR IDATFQSFLK 

        70         80         90        100        110        120 
LQKKYGSVFT VYFGPRPVVI LCGHEAVKEA LVDQADDFSG RGEMPTLEKN FQGYGLALSN 

       130        140        150        160        170        180 
GERWKILRRF SLTVLRNFGM GKRSIEERIQ EEAGYLLEEL HKVKGAPIDP TFYLSRTVSN 

       190        200        210        220        230        240 
VICSVVFGKR FDYEDQRFRS LMKMINESFV EMSMPWAQLY DMYWGVIQYF PGRHNRLYNL 

       250        260        270        280        290        300 
IEELKDFIAS RVKINEASFD PSNPRDFIDC FLIKMYQDKS DPHSEFNLKN LVLTTLNLFF 

       310        320        330        340        350        360 
AGTETVSSTL RYGFLLLMKY PEVEAKIHEE INQVIGTHRT PRVDDRAKMP YTDAVIHEIQ 

       370        380        390        400        410        420 
RLTDIVPLGV PHNVIRDTHF RGYFLPKGTD VYPLIGSVLK DPKYFRYPEA FYPQHFLDEQ 

       430        440        450        460        470        480 
GRFKKNDAFV AFSSGKRICV GEALARMELF LYFTSILQRF SLRSLVPPAD IDIAHKISGF 

       490 
GNIPPTYELC FMAR

« Hide

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References

[1]"Olfactory-specific cytochrome P-450 (P-450olf1; IIG1). Gene structure and developmental regulation."
Nef P., Larabee T.M., Kagimoto K., Meyer U.A.
J. Biol. Chem. 265:2903-2907(1990) [PubMed: 2406242] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Olfactory-specific cytochrome P-450. cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception."
Nef P., Heldman J., Lazard D., Margalit T., Jaye M., Hanukoglu I., Lancet D.
J. Biol. Chem. 264:6780-6785(1989) [PubMed: 2708343] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 2-494.

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Cross-references

Sequence databases

M31931 expand/collapse EMBL AC list , M31923, M31924, M31925, M31926, M31927, M31928, M31929, M31930 Genomic DNA. Translation: AAA41069.1.
M33296 mRNA. Translation: AAA41070.2.
PIRA35551.
RefSeqNP_036919.1.
UniGeneRn.10909

3D structure databases

HSSPHSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000020827. Rattus norvegicus. [Contig view]
GeneID25251.
KEGGrno:25251.

Organism-specific databases

RGD2477. Cyp2g1.

Phylogenomic databases

HOVERGENP10610.

Gene expression databases

ArrayExpressP10610.
GermOnlineENSRNOG00000020827. Rattus norvegicus.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP10610.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameCP2G1_RAT
AccessionPrimary (citable) accession number: P10610
Secondary accession number(s): Q64589
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 2, 2008
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents