Reviewed,
UniProtKB/Swiss-Prot P10394 (POL4_DROME)
Last modified
July 22, 2008.
Version 69.
History...
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90%,
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Retrovirus-related Pol polyprotein from transposon 412 Including the following 3 domains: 1- Recommended name: Protease EC=3.4.23.- 2- Recommended name: Reverse transcriptase EC=2.7.7.49 3- Recommended name: Endonuclease | ||||
| Gene names |
| ||||
| Organism | Drosophila melanogaster (Fruit fly) | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 1237 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Predicted. |
General annotation (Comments)
| Catalytic activity | Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| Sequence similarities | Contains 1 integrase catalytic domain. Contains 1 peptidase A2 domain. Contains 1 reverse transcriptase domain. |
Ontologies
Keywords | |
|---|---|
| Molecular function | Aspartyl protease Endonuclease Hydrolase Nuclease Nucleotidyltransferase Protease RNA-directed DNA polymerase Transferase |
| Technical term | Transposable element |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1237 | 1237 | Retrovirus-related Pol polyprotein from transposon 412 | |||||
Regions | ||||||||
| Domain | 58 – 131 | 74 | Peptidase A2 | |||||
| Domain | 338 – 523 | 186 | Reverse transcriptase | |||||
| Domain | 957 – 1119 | 163 | Integrase catalytic | |||||
Sites | ||||||||
| Active site | 63 | 1 | For protease activity By similarity | |||||
Sequences
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References
| [1] | "Nucleotide sequence characterization of a Drosophila retrotransposon, 412." Yuki S., Inouye S., Ishimaru S., Saigo K. Eur. J. Biochem. 158:403-410(1986) [PubMed: 2426108] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| X04132 Genomic DNA. Translation: CAA27750.1. | |
| PIR | GNFF42. D29349. |
3D structure databases | |
| HSSP | HSSP built from PDB template 4FIV based on UniProtKB P16088. |
| ModBase | Search... |
Organism-specific databases | |
| FlyBase | FBgn0043847. 412\ORF3. |
Family and domain databases | |
| InterPro | IPR000477. DNA_pol_RVTase. IPR001584. Integrase_cat-core. IPR001969. Pept_Asp_AS. IPR001995. Peptidase_A2_cat. [Graphical view] |
| Pfam | PF00665. rve. 1 hit. PF00077. RVP. 1 hit. PF00078. RVT_1. 1 hit. [Graphical view] |
| PROSITE | PS50175. ASP_PROT_RETROV. 1 hit. PS00141. ASP_PROTEASE. 1 hit. PS50994. INTEGRASE. 1 hit. PS50878. RT_POL. 1 hit. [Graphical view] |
| ProDom | P10394. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | POL4_DROME | ||||||||
| Accession | Primary (citable) accession number: P10394 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |
