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Reviewed, UniProtKB/Swiss-Prot P09774 (AST3_DROME)

Last modified November 4, 2008. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Achaete-scute complex protein T3
Alternative name(s):
    Lethal of scute protein
      Short name=Lethal of sc
Gene names
Name: l(1)sc
Synonyms: l'sc, T3
ORF Names: CG3839
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Tissue specificity

L(1)SC, SC and AC strongly label the presumptive stomatogastric nervous system, while ASE is more prominent in the presumptive procephalic lobe.

Miscellaneous

AS-C proteins are expressed first earlier in ectoderm and then in the internalized neuroblasts, while T8 is expressed in presumptive neural precursors, once they have segregated from the ectoderm.

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Achaete-scute complex protein T3
PRO_0000127135

Regions

Domain97 – 14650Helix-loop-helix motif
DNA binding86 – 9611Basic motif

Experimental info

Sequence conflict1981H → R in CAA31065. Ref.1
Sequence conflict2571Q → R in AAM52020. Ref.6

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Sequences

Sequence LengthMass (Da)Tools
P09774-1 [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: 1AEC8FA0B3144F87

FASTA25728,972
        10         20         30         40         50         60 
MTSICSSKFQ QQHYQLTNSN IFLLQHQHHH QTQQHQLIAP KIPLGTSQLQ NMQQSQQSNV 

        70         80         90        100        110        120 
GPMLSSQKKK FNYNNMPYGE QLPSVARRNA RERNRVKQVN NGFVNLRQHL PQTVVNSLSN 

       130        140        150        160        170        180 
GGRGSSKKLS KVDTLRIAVE YIRGLQDMLD DGTASSTRHI YNSADESSND GSSYNDYNDS 

       190        200        210        220        230        240 
LDSSQQFLTG ATQSAQSHSY HSASPTPSYS GSEISGGGYI KQELQEQDLK FDSFDSFSDE 

       250 
QPDDEELLDY ISSWQEQ

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References

« Hide 'large scale' references
[1]"The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes."
Alonso M.C., Cabrera C.V.
EMBO J. 7:2585-2591(1988) [PubMed: 2461300] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: Canton-S.
[2]"Molecular characterization of the lethal of scute genetic function."
Martin-Bermudo M.D., Gonzalez F., Dominguez M., Rodriguez I., Ruiz-Gomez M., Romani S., Modolell J., Jimenez F.
Development 118:1003-1012(1993) [PubMed: 8076513] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Canton-S.
Tissue: Embryo.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[5]"From sequence to chromosome: the tip of the X chromosome of D. melanogaster."
Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. expand/collapse author list , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M.
Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Oregon-R.
[6]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.

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Cross-references

Sequence databases

X12549 Genomic DNA. Translation: CAA31065.1.
X71806 mRNA. Translation: CAA50680.1.
AE014298 Genomic DNA. Translation: AAF45500.1.
AL024453 Genomic DNA. Translation: CAA19656.1.
AY121693 mRNA. Translation: AAM52020.1.
PIRS01165.
RefSeqNP_476623.1.
UniGeneDm.1705

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP09774.

Genome annotation databases

EnsemblCG3839. Drosophila melanogaster. [Contig view]
GeneID30983.
KEGGdme:Dmel_CG3839.
NMPDRfig|7227.3.peg.15889.

Organism-specific databases

FlyBaseFBgn0002561. l(1)sc.

Phylogenomic databases

HOGENOMP09774.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-000020-MON.

Gene expression databases

ArrayExpressP09774.
GermOnlineCG3839. Drosophila melanogaster.

Family and domain databases

InterProIPR015660. ASH.
IPR001092. HLH_basic.
IPR011598. HLH_DNA_bd.
[Graphical view]
Gene3DG3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
PANTHERPTHR13935. ASH. 1 hit.
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
PROSITEPS50888. HLH. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio771316.

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Entry information

Entry nameAST3_DROME
AccessionPrimary (citable) accession number: P09774
Secondary accession number(s): Q24387, Q8MRA5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 21, 2001
Last modified: November 4, 2008
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents