Reviewed,
UniProtKB/Swiss-Prot P08910 (ABHD2_HUMAN)
Last modified
July 22, 2008.
Version 69.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Abhydrolase domain-containing protein 2 EC=3.1.1.- Alternative name(s): Lung alpha/beta hydrolase 2 Protein PHPS1-2 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 425 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May play a role in smooth muscle cells migration By similarity. |
| Subcellular location | Membrane; Single-pass type II membrane proteinPotential. |
| Sequence similarities | Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. |
| Caution | Was originally (Ref.1) thought to be a G-coupled receptor. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Hydrolase Serine esterase |
Gene Ontology (GO) | |
| Cellular component | integral to membrane Non-traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 425 | 425 | Abhydrolase domain-containing protein 2 | |||||
Regions | ||||||||
| Transmembrane | 10 – 30 | 21 | Signal-anchor for type II membrane protein Potential | |||||
Sites | ||||||||
| Active site | 207 | 1 | Charge relay system By similarity | |||||
| Active site | 345 | 1 | Charge relay system By similarity | |||||
| Active site | 376 | 1 | Charge relay system By similarity | |||||
Natural variations | ||||||||
| Natural variant | 253 | 1 | R → Q: dbSNP rs17851730. | |||||
Experimental info | ||||||||
| Sequence conflict | 27 | 1 | Y → C in BAD96803. Ref.3 | |||||
| Sequence conflict | 388 | 1 | E → G in BAD96561. Ref.3 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Primary structure of a human protein which bears structural similarities to members of the rhodopsin/beta-adrenergic receptor family." Rapiejko P.J., George S.T., Malbon C.C. Nucleic Acids Res. 16:8721-8721(1988) [PubMed: 2843827] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta. |
| [2] | "Cloning of an androgen-regulated a/b hydrolase." Utleg A., White J., Lin B. Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Gastric carcinoma and Liver. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-253. Tissue: Testis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X12433 mRNA. Translation: CAA30976.1. AF546700 mRNA. Translation: AAQ12021.1. AK222841 mRNA. Translation: BAD96561.1. AK223083 mRNA. Translation: BAD96803.1. BC019248 mRNA. Translation: AAH19248.1. BC090052 mRNA. Translation: AAH90052.1. | |
| PIR | A31026. |
| RefSeq | NP_008942.3. NP_690888.1. |
| UniGene | Hs.122337 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000140526. Homo sapiens. [Contig view] |
| GeneID | 11057. |
| KEGG | hsa:11057. |
Organism-specific databases | |
| H-InvDB | HIX0019138. |
| HGNC | HGNC:18717. ABHD2. |
| HPA | HPA005999. |
| PharmGKB | PA38658. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | P08910. |
Gene expression databases | |
| ArrayExpress | P08910. |
| CleanEx | HS_ABHD2. |
| GermOnline | ENSG00000140526. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR012020. AB-Hydro_YheT. IPR000073. AB_hydrolase_1. IPR000952. UPF0017_hydro-like_CS. [Graphical view] |
| Pfam | PF00561. Abhydrolase_1. 1 hit. [Graphical view] |
| PIRSF | PIRSF005211. Ab_hydro_YheT. 1 hit. |
| PROSITE | PS01133. UPF0017. 1 hit. [Graphical view] |
| ProDom | P08910. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | ABHD2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P08910 Secondary accession number(s): Q53G48  Q8TC79 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 15 Human chromosome 15: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |
