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Reviewed, UniProtKB/Swiss-Prot P05185 (CP17A_BOVIN)

Last modified September 2, 2008. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome P450 17A1
    EC=1.14.99.9
Alternative name(s):
    CYPXVII
    P450-C17
      Short name=P450c17
    Steroid 17-alpha-hydroxylase/17,20 lyase
Gene names
Name: CYP17A1
Synonyms: CYP17
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

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Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activity

A steroid + AH(2) + O(2) = a 17-alpha-hydroxysteroid + A + H(2)O.

Cofactor

Heme group By similarity.

Enzyme regulation

Regulated predominantly by intracellular cAMP levels.

Pathway

Lipid metabolism; steroid biosynthesis.

Subcellular location

MembranePotential. Membrane; Single-pass membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

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Ontologies

Keywords

   Biological processSteroidogenesis
   Cellular componentMembrane
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase

Gene Ontology (GO)

None. [Check GOA]

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 509509Cytochrome P450 17A1

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict2401N → K in AAI10170. Ref.3
Sequence conflict4231T → A Ref.2
Sequence conflict4581R → W Ref.2
Sequence conflict5091P → S Ref.2

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Sequences

Sequence LengthMass (Da)Tools
P05185-1 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: 64B0E5537A474BB7

FASTA50957,244
        10         20         30         40         50         60 
MWLLLAVFLL TLAYLFWPKT KHSGAKYPRS LPSLPLVGSL PFLPRRGQQH KNFFKLQEKY 

        70         80         90        100        110        120 
GPIYSFRLGS KTTVMIGHHQ LAREVLLKKG KEFSGRPKVA TLDILSDNQK GIAFADHGAH 

       130        140        150        160        170        180 
WQLHRKLALN AFALFKDGNL KLEKIINQEA NVLCDFLATQ HGEAIDLSEP LSLAVTNIIS 

       190        200        210        220        230        240 
FICFNFSFKN EDPALKAIQN VNDGILEVLS KEVLLDIFPV LKIFPSKAME KMKGCVQTRN 

       250        260        270        280        290        300 
ELLNEILEKC QENFSSDSIT NLLHILIQAK VNADNNNAGP DQDSKLLSNR HMLATIGDIF 

       310        320        330        340        350        360 
GAGVETTTSV IKWIVAYLLH HPSLKKRIQD DIDQIIGFNR TPTISDRNRL VLLEATIREV 

       370        380        390        400        410        420 
LRIRPVAPTL IPHKAVIDSS IGDLTIDKGT DVVVNLWALH HSEKEWQHPD LFMPERFLDP 

       430        440        450        460        470        480 
TGTQLISPSL SYLPFGAGPR SCVGEMLARQ ELFLFMSRLL QRFNLEIPDD GKLPSLEGHA 

       490        500 
SLVLQIKPFK VKIEVRQAWK EAQAEGSTP

« Hide

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References

« Hide 'large scale' references
[1]"Bovine adrenocortical cytochrome P-450(17 alpha). Regulation of gene expression by ACTH and elucidation of primary sequence."
Zuber M.X., John M.E., Okamura T., Simpson E.R., Waterman M.R.
J. Biol. Chem. 261:2475-2482(1986) [PubMed: 3003117] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structural characterization of the bovine CYP17 (17 alpha-hydroxylase) gene."
Bhasker C.R., Adler B.S., Dee A., John M.E., Kagimoto M., Zuber M.X., Ahlgren R., Wang X.D., Simpson E.R., Waterman M.R.
Arch. Biochem. Biophys. 271:479-487(1989) [PubMed: 2543297] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Crossbred X Angus.
Tissue: Liver.

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Cross-references

Sequence databases

M12547 mRNA. Translation: AAA30485.1.
BC110169 mRNA. Translation: AAI10170.1.
PIRS04346.
RefSeqNP_776729.1.
UniGeneBt.89153

3D structure databases

HSSPHSSP built from PDB template 1DT6 based on UniProtKB P00179.
ModBaseSearch...

Genome annotation databases

EnsemblENSBTAG00000014335. Bos taurus. [Contig view]
GeneID281739.
KEGGbta:281739.

Phylogenomic databases

HOVERGENP05185.

Family and domain databases

InterProIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
Gene3DG3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHERPTHR19383. Cyt_P450. 1 hit.
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProDomP05185.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameCP17A_BOVIN
AccessionPrimary (citable) accession number: P05185
Secondary accession number(s): Q2YDL3
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: September 2, 2008
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents