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Reviewed, UniProtKB/Swiss-Prot P04323 (POL3_DROME)

Last modified July 22, 2008. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Retrovirus-related Pol polyprotein from transposon 17.6
Including the following 3 domains:
    1- Recommended name:
            Protease
              EC=3.4.23.-
    2- Recommended name:
            Reverse transcriptase
              EC=2.7.7.49
    3- Recommended name:
            Endonuclease
Gene names
Name: pol
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length1058 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existencePredicted.

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General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Miscellaneous

The open reading frame is located in a copia-like transposable element called 17.6.

Sequence similarities

Contains 1 integrase catalytic domain.

Contains 1 peptidase A2 domain.

Contains 1 reverse transcriptase domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 10581058Retrovirus-related Pol polyprotein from transposon 17.6

Regions

Domain231 – 415185Reverse transcriptase
Domain810 – 967158Integrase catalytic

Sites

Active site301For protease activity By similarity

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Sequences

Sequence LengthMass (Da)Tools
P04323-1 [UniParc].

Last modified March 20, 1987. Version 1.
Checksum: C893F5C4A7E1F091

FASTA1,058122,698
        10         20         30         40         50         60 
TGRKFSATSL GKPQYITIKY KENNLKCLID TGSTVNMTSK NIFDLPIQNT STFIHTSNGP 

        70         80         90        100        110        120 
LIVNKSIIIP SKILFPTTNE FLLHPFSENY DLLLGRKLLA EAKATISYRD QEVTLYNNKY 

       130        140        150        160        170        180 
KLIEGIATHE QSHFQNVNMI PDTMLRQPNK ISPILESDLY RLEHLNNEEK QRLCALLQKY 

       190        200        210        220        230        240 
HDIQYHEGDK LTFTNQTKHT INTKHNLPLY SKYSYPQAYE QEVESQIQDM LNQGIIRTSN 

       250        260        270        280        290        300 
SPYNSPIWVV PKKQDASGKQ KFRIVIDYRK LNEITVGDRH PIPNMDEILG KLGRCNYFTT 

       310        320        330        340        350        360 
IDLAKGFHQI EMDPESVSKT AFSTKHGHYE YLRMPFGLKN APATFQRCMN DILRPLLNKH 

       370        380        390        400        410        420 
CLVYLDDIIV FSTSLDEHLQ SLGLVFEKLA KANLKLQLDK CEFLKQETTF LGHVLTPDGI 

       430        440        450        460        470        480 
KPNPEKIEAI QKYPIPTKPK EIKAFLGLTG YYRKFIPNFA DIAKPMTKCL KKNMKIDTTN 

       490        500        510        520        530        540 
PEYDSAFKKL KYLISEDPIL KVPDFTKKFT LTTDASDVAL GAVLSQDGHP LSYISRTLNE 

       550        560        570        580        590        600 
HEINYSTIEK ELLAIVWATK TFRHYLLGRH FEISSDHQPL SWLYRMKDPN SKLTRWRVKL 

       610        620        630        640        650        660 
SEFDFDIKYI KGKENCVADA LSRIKLEETY LSEQTQHSAE EDNSDLIFIT ERPLNTFNRQ 

       670        680        690        700        710        720 
VIFSKGPPDI KVTKYFKKHI TQIFYDIMTR EKAEQYLIDH FCGKKSALYI ESDADFEVIQ 

       730        740        750        760        770        780 
AAHKLAINTK YTKILRSTIL LKNITTYAEF KELILTAHEK LLHPGIQKTT KLFGETYYFP 

       790        800        810        820        830        840 
NSQLLIQNII NECSICNLAK TEHRNTDMPT KTTPKPEHCR EKFMIDIYSS EGKHYVSCID 

       850        860        870        880        890        900 
IYSKFATLEE IKTKDWIECK NALMRIFNQL GKPKLLKADR DGAFSSLALK RWLESEEVEL 

       910        920        930        940        950        960 
QLNTTKTGVA DIERLHKTIN EKIRIIKTSD DEETKLSKME TVLNIYNHKT KHDTTGQTPA 

       970        980        990       1000       1010       1020 
HIFLYAGQPI LDTQQNKENK INKINNDRVE YEVDTRYRKG PLQKGKLENP FKPTKNVEQT 

      1030       1040       1050 
DSDHYKITNR NRITHYYKTQ FKKRKKNNQL SISQAPGT

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References

[1]"Identification of the coding sequence for a reverse transcriptase-like enzyme in a transposable genetic element in Drosophila melanogaster."
Saigo K., Kugimiya W., Matsuo Y., Inouye S., Yoshioka K., Yuki S.
Nature 312:659-661(1984) [PubMed: 6209583] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

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Cross-references

Sequence databases

X01472 Genomic DNA. Translation: CAA25702.1.
PIRGNFF17. A03971.

3D structure databases

ModBaseSearch...

Protein family/group databases

MEROPSA02.052.

Organism-specific databases

FlyBaseFBgn0014453. 17.6\pol.

Family and domain databases

InterProIPR000477. DNA_pol_RVTase.
IPR001584. Integrase_cat-core.
IPR001969. Pept_Asp_AS.
IPR001995. Peptidase_A2_cat.
[Graphical view]
PfamPF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
PROSITEPS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]
ProDomP04323.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry namePOL3_DROME
AccessionPrimary (citable) accession number: P04323
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 1987
Last sequence update: March 20, 1987
Last modified: July 22, 2008
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents