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Reviewed, UniProtKB/Swiss-Prot O77237 (PELI_DROME)

Last modified July 22, 2008. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein pellino
Gene names
Name: Pli
ORF Names: CG5212
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Scaffold protein involved in the Toll signaling pathway via its interaction with Pelle/Pll kinase.

Subunit structure

Interacts with Pll.

Sequence similarities

Belongs to the pellino family.

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Ontologies

Keywords

   PTMPhosphoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processToll signaling pathway Ref.1

Inferred from mutant phenotype. Source: UniProtKB

immune response

Traceable author statement. Source: FlyBase

   Molecular functionkinase regulator activity Ref.1

Inferred from mutant phenotype. Source: UniProtKB

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 424424Protein pellino

Amino acid modifications

Modified residue101Phosphoserine

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Sequences

Sequence LengthMass (Da)Tools
O77237-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: B6A99CB1C72C5F40

FASTA42446,770
        10         20         30         40         50         60 
MVKRTDGTES PILAEDGGDG HDKPRLRYGE LVILGYNGYL PQGDRGRRRS KFVLHKRTEA 

        70         80         90        100        110        120 
SGVKRSKHYI VQSPQTSKAI LDANQHSISY TLSRNQAVIV EYKEDTETDM FQVGRSSESP 

       130        140        150        160        170        180 
IDFVVMDTLP GDKKDAKVMQ STISRFACRI LVNRCEPAKA RIFAAGFDSS RNIFLGEKAT 

       190        200        210        220        230        240 
KWQDNVEIDG LTTNGVLIMH PKGSFCGGNA KCGLWRECSV GGDVFSLRES RSAQQKGQPI 

       250        260        270        280        290        300 
YDECNILQDG TLIDLCGATL LWRSAEGLQH SPTKHDLEKL IDAINAGRPQ CPVGLNTLVI 

       310        320        330        340        350        360 
PRKVNIGDQV NQPYVYLNCG HVQGHHDWGQ DENTGARRCP MCLELGPVVT LCMGLEPAFY 

       370        380        390        400        410        420 
VDVGAPTYAF NPCGHMATEK TVKYWANVEI PHGTNGFQAV CPFCATPLDG ATGYIKLIFQ 


DNLD

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References

« Hide 'large scale' references
[1]"Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal."
Grosshans J., Schnorrer F., Nuesslein-Volhard C.
Mech. Dev. 81:127-138(1999) [PubMed: 10330490] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PLL.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, MASS SPECTROMETRY.
Tissue: Embryo.

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Cross-references

Sequence databases

AF091624 mRNA. Translation: AAC96298.1.
AE014297 Genomic DNA. Translation: AAF56198.1.
AY069632 mRNA. Translation: AAL39777.1.
RefSeqNP_001097890.1.
NP_001097891.1.
NP_524466.1.
UniGeneDm.1303

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActO77237.

Genome annotation databases

EnsemblCG5212. Drosophila melanogaster. [Contig view]
GeneID42821.
KEGGdme:Dmel_CG5212.
NMPDRfig|7227.3.peg.14304.

Organism-specific databases

FlyBaseFBgn0025574. Pli.

Phylogenomic databases

HOGENOMO77237.

Enzyme and pathway databases

BioCycDMEL-XXX-02:DMEL-XXX-02-013053-MON.

Gene expression databases

ArrayExpressO77237.
GermOnlineCG5212. Drosophila melanogaster.

Family and domain databases

InterProIPR006800. Pellino.
[Graphical view]
PANTHERPTHR12098:SF2. Pellino. 1 hit.
PfamPF04710. Pellino. 1 hit.
[Graphical view]
ProDomO77237.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry namePELI_DROME
AccessionPrimary (citable) accession number: O77237
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1998
Last modified: July 22, 2008
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents