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Reviewed, UniProtKB/Swiss-Prot O01668 (OPS6_DROME)

Last modified April 8, 2008. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesOpsin Rh6
Also known as:
     Rhodopsin Rh6, long-wavelength
Gene names
Name: Rh6
ORF Names: CG5192
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Each Drosophila eye is composed of 800 facets or ommatidia. Each ommatidium contains 8 photoreceptor cells (R1-R8), the R1 to R6 cells are outer cells, while R7 and R8 are inner cells. Rh6 is expressed in a subset of R8 cells, most likely expressed in the subset of R8 cells paired with Rh4-expressing R7 cells (R7y).

Post-translational modification

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

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Ontologies

Keywords

   Biological processSensory transduction
Vision
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
   LigandChromophore
   Molecular functionG-protein coupled receptor
Photoreceptor protein
Receptor
Retinal protein
Transducer
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processphototransduction

Inferred from genetic interaction. Source: FlyBase

   Cellular componentrhabdomere

Inferred from direct assay. Source: FlyBase

   Molecular functionG-protein coupled photoreceptor activity

Inferred from genetic interaction. Source: FlyBase

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform B (identifier: O01668-1)
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: O01668-2)
The sequence of this isoform differs from the canonical sequence as follows:
     230-369: Missing.
Notes: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 369369Opsin Rh6

Regions

Topological domain1 – 4646Extracellular
Transmembrane47 – 71251 Potential
Topological domain72 – 8312Cytoplasmic
Transmembrane84 – 109262 Potential
Topological domain110 – 12314Extracellular
Transmembrane124 – 143203 Potential
Topological domain144 – 16219Cytoplasmic
Transmembrane163 – 186244 Potential
Topological domain187 – 21024Extracellular
Transmembrane211 – 238285 Potential
Topological domain239 – 27436Cytoplasmic
Transmembrane275 – 298246 Potential
Topological domain299 – 3057Extracellular
Transmembrane306 – 330257 Potential
Topological domain331 – 36939Cytoplasmic

Sites

Binding site3171Retinal chromophore (covalent) By similarity

Amino acid modifications

Glycosylation171N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential
Glycosylation2081N-linked (GlcNAc...) Potential
Disulfide bond120 ↔ 197 Potential

Natural variations

Alternative sequence230 – 369140Missing in isoform A.

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Sequences

Sequence LengthMass (Da)Tools
Isoform B [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 5670A7435AD5F244

FASTA36941,691
        10         20         30         40         50         60 
MASLHPPSFA YMRDGRNLSL AESVPAEIMH MVDPYWYQWP PLEPMWFGII GFVIAILGTM 

        70         80         90        100        110        120 
SLAGNFIVMY IFTSSKGLRT PSNMFVVNLA FSDFMMMFTM FPPVVLNGFY GTWIMGPFLC 

       130        140        150        160        170        180 
ELYGMFGSLF GCVSIWSMTL IAYDRYCVIV KGMARKPLTA TAAVLRLMVV WTICGAWALM 

       190        200        210        220        230        240 
PLFGWNRYVP EGNMTACGTD YFAKDWWNRS YIIVYSLWVY LTPLLTIIFS YWHIMKAVAA 

       250        260        270        280        290        300 
HEKAMREQAK KMNVASLRNS EADKSKAIEI KLAKVALTTI SLWFFAWTPY TIINYAGIFE 

       310        320        330        340        350        360 
SMHLSPLSTI CGSVFAKANA VCNPIVYGLS HPKYKQVLRE KMPCLACGKD DLTSDSRTQA 


TAEISESQA

« Hide

Isoform A [UniParc].

Checksum: EEB0CCDB777FDBEE
Show »

22926,194

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References

« Hide 'large scale' references
[1]"Molecular cloning of Drosophila Rh6 rhodopsin: the visual pigment of a subset of R8 photoreceptor cells."
Huber A., Schulz S., Bentrop J., Groell C., Wolfrum U., Paulsen R.
FEBS Lett. 406:6-10(1997) [PubMed: 9109375] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
Strain: Oregon-R.
Tissue: Retina.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Strain: Berkeley.
Tissue: Head.

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Cross-references

Sequence databases

Z86118 mRNA. Translation: CAB06821.1.
AE014297 Genomic DNA. Translation: AAN13666.2.
AY089666 mRNA. Translation: AAL90404.1.
RefSeqNP_524368.3.
UniGeneDm.1656

3D structure databases

HSSPHSSP built from PDB template 1EDV based on UniProtKB P02699.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

GeneID41889.
KEGGdme:Dmel_CG5192.

Organism-specific databases

FlyBaseFBgn0019940. Rh6.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR001760. Opsin.
IPR001735. Opsin_RH1/RH2.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00238. OPSIN.
PR00576. OPSINRH1RH2.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS00238. OPSIN. 1 hit.
[Graphical view]
ProDomO01668.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

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Entry information

Entry nameOPS6_DROME
AccessionPrimary (citable) accession number: O01668
Secondary accession number(s): Q8SXF4, Q9VF58
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 8, 2008
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents