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UniProt is updated every four weeks (see FAQ on how to be notified automatically of updates). You can download small data sets and subsets directly from this web site by following the download link on any search result page. For downloading complete data sets we recommend using If you are located in Europe, the Middle East or Africa, you may want to download data from our mirror site in the United Kingdom or in Switzerland instead.

Here are some direct links to frequently downloaded files:


Parent Directory (FTP)
Reviewed (Swiss-Prot)xml | fasta | text
Unreviewed (TrEMBL)xml | fasta | text
Isoform sequencesfasta
Taxonomic divisionstext
Reference proteomes
ID mapping datatab
XML Schema


Parent Directory (FTP)
UniRef100xml | fasta
UniRef90xml | fasta
UniRef50xml | fasta
XML Schema


Parent Directory (FTP)
UniParc (Sequence Archive)xml | fasta
XML Schema


Parent Directory (FTP)
Metagenomic and Environmental Sequencesfasta
UniMES matches to InterPro methods

UniProt RDF distribution

Parent Directory (FTP)

UniProt information

Releases notes
Previous releases