---------------------------------------------------------------------------- UniProt - Swiss-Prot Protein Knowledgebase SIB Swiss Institute of Bioinformatics; Geneva, Switzerland European Bioinformatics Institute (EBI); Hinxton, United Kingdom Protein Information Resource (PIR); Washington DC, USA ---------------------------------------------------------------------------- Description: Vertebrate homeotic Hox proteins: nomenclature and list of entries Name: hoxlist.txt Release: 2024_02 of 27-Mar-2024 ---------------------------------------------------------------------------- Background information The homeotic Hox proteins are sequence-specific transcription factor which are part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior (A-P) axis [1]. The hox proteins contain an 'homeobox' domain. In Drosophila and other insects there are eight different Hox genes that are encoded in two gene complexes: ANT-C and BX-C; while in vertebrates there are 39 genes organized in four complexes. In 1992/93 [2,3] a new nomenclature system was proposed for Hox genes. The four gene complexes are assigned the letters A to D. Based on sequence similarities the genes can be sorted into 13 'paralog' groups. The order of the paralogs along the chromosomes are conserved in the four complexes. The gene name is obtained by concatenating the gene complex letter designation with the group number; examples: HOXA1, HOXB4, HOXC8, HOXD13, etc. In several cases a representative of a paralog group is absent from a complex, in such cases that gene number is omitted. For example: HOXA8, HOXC1 and HOXD2 do not exist. We have fully implemented this nomenclature system in Swiss-Prot. [ 1] McGinnis W., Krumlauf R. Cell 68:283-302(1992). PubMed=1346368; [ 2] Scott M.P. Cell 71:551-553(1992). PubMed=1358459; [ 3] Scott M.P. Nucleic Acids Res. 21:1687-1688(1993). PubMed=8098522; ======================================= Table of the nomenclature for HOX genes ======================================= New Previous Previous Other Other Other previous names used gene Human Mouse Mouse Human in various species name name name names names ______ ______ ________ ____________ _________ __________________________ HOXA1 HOX1F HOX-1.6 era-1 HOXA2 HOX1K HOX-1.11 NvHbox-2.8 HOXA3 HOX1E HOX-1.5 mo-10 HOXA4 HOX1D HOX-1.4 mh-3 R2; Chox-1.4; Zf-26 HOXA5 HOX1C HOX-1.3 m2 s12-B HOXA6 HOX1B HOX-1.2 m5-4 HOXA7 HOX1A HOX-1.1 m6-12; m6 R5; Quox-1; XlHbox-3; Xhox-36 HOXA9 HOX1G HOX-1.7 HOXA10 HOX1H HOX-1.8 PL HOXA11 HOX1I HOX-1.9 Ghox-1i; Chox-1.9 HOXA13 HOX1J HOX-1.10 HOXB1 HOX2I HOX-2.9 Ghox-lab; AHox1 HOXB2 HOX2H HOX-2.8 K8 s6 HOXB3 HOX2G HOX-2.7 mh-23 Chox-2.7; XlHox-2.7 HOXB4 HOX2F HOX-2.6 Chox-Z; Xhox-1A HOXB5 HOX2A HOX-2.1 Mu-1; H24.1 Hu-1; c10 Ohox-2.1; Ghox-2.1; XlHbox-4; Xhox-1B; Zf-21 HOXB6 HOX2B HOX-2.2 mh-22A Hu-2 Ghox-2.2; XlHox-2.2; Zf-22 HOXB7 HOX2C HOX-2.3 mh-22B; mub1 c1 R1b; XlHbox-2; MM3 HOXB8 HOX2D HOX-2.4 R1a; Chox-2.4 HOXB9 HOX2E HOX-2.5 XlHbox-6 HOXB10 - - Does not exist in mammals. HOXB13 - - HOXC1 - - Does not exist in mammals. HOXC3 - - Does not exist in mammals. HOXC4 HOX3E HOX-3.5 cp19 R3 HOXC5 HOX3D HOX-3.4 Hox-6.2 cp11 XlHbox-5; NvHbox-3.4; Zf-25 HOXC6 HOX3C HOX-3.3 Hox-6.1 c8; cp25 NvHox-1; FH-2; XlHbox-1; AC1; Zf-61 HOXC8 HOX3A HOX-3.1 m31 R4 HOXC9 HOX3B HOX-3.2 HOXC10 HOX3I HOX-3.6 HOXC11 HOX3H HOX-3.7 HOXC12 HOX3F HOX-3.8 HOXC13 HOX3G HOX-3.9 HOXD1 HOX4G HOX-4.9 HOXD3 HOX4A HOX-4.1 mh-19 Hox-7.1; R6 HOXD4 HOX4B HOX-4.2 Hox-5.1 c13 Hox-8.1; Chox-A; Zf-13 HOXD5 - - Does not exist in mammals. HOXD8 HOX4E HOX-4.3 Hox-5.4 Chox-M HOXD9 HOX4C HOX-4.4 Hox-5.2 Chox-4.4 HOXD10 HOX4D HOX-4.5 Hox-5.3 Hox4E Chox-4.5; Chox-4d HOXD11 HOX4F HOX-4.6 Hox-5.5 Chox-4.6; Ghox-4.6; Chox-4e; NvHox-2 HOXD12 HOX4H HOX-4.7 Hox-5.6 Chox-4.7; Chox-4f HOXD13 HOX4I HOX-4.8 Hox-5.7 Chox-4.8; Chox-4g ================================ Swiss-Prot entries for HOX genes ================================ Hox sequences in vertebrates ---------------------------- A1 P49639; HXA1_HUMAN P09022; HXA1_MOUSE O08656; HXA1_RAT Q98SI1; HXA1A_DANRE Q1KL10; HXA1A_TAKRU Q9IA19; HXA1_HETFR Q08821; HXA1_XENLA A2 Q0VCS4; HXA2_BOVIN B0VXK3; HXA2_CALJA O43364; HXA2_HUMAN P31245; HXA2_MOUSE A9L937; HXA2_PAPAN P31246; HXA2_RAT Q08727; HXA2_CHICK O42365; HXA2B_DANRE Q1KL11; HXA2A_TAKRU Q1KKZ2; HXA2B_TAKRU Q9IA20; HXA2_HETFR P31261; HXA2_NOTVI A3 Q08DG7; HXA3_BOVIN O43365; HXA3_HUMAN P02831; HXA3_MOUSE O93353; HXA3_CHICK Q8AWZ2; HXA3A_DANRE Q1KL12; HXA3A_TAKRU Q9IA21; HXA3_HETFR A4 Q00056; HXA4_HUMAN P06798; HXA4_MOUSE P09635; HXA4_RAT Q28598; HXA4_SHEEP P17277; HXA4_CHICK Q9PWL5; HXA4A_DANRE Q1KL13; HXA4A_TAKRU Q9IA22; HXA4_HETFR Q9PWD2; HXA4_MORSA P81192; HXA4_LINSA A5 Q2HJ67; HXA5_BOVIN P20719; HXA5_HUMAN A2D5K9; HXA5_LAGLA A2D5Y4; HXA5_LEMCA P09021; HXA5_MOUSE P52949; HXA5_RAT Q28599; HXA5_SHEEP Q6B3N0; HXA5_CHICK Q9YGT6; HXA5A_DANRE Q1KL14; HXA5A_TAKRU Q9IA23; HXA5_HETFR Q9PWD3; HXA5_MORSA P09637; HXA5_SALSA P50208; HXA5_AMBME A6 P31267; HXA6_HUMAN P09092; HXA6_MOUSE Q5YLH5; HXA6_CHICK Q9IA24; HXA6_HETFR A7 P31268; HXA7_HUMAN P02830; HXA7_MOUSE A1YGK7; HXA7_PANPA A2T7F3; HXA7_PANTR P09634; HXA7_RAT Q28600; HXA7_SHEEP Q90VZ9; HXA7_CHICK P24061; HXA7_COTJA Q9IA25; HXA7_HETFR Q9PWD4; HXA7_MORSA P09636; HXA7_SALSA P09071; HXA7_XENLA A9 P51783; HXA9_CAVPO P31269; HXA9_HUMAN P09631; HXA9_MOUSE Q98924; HXA9_CHICK Q9PWL6; HXA9A_DANRE Q9YGT5; HXA9B_DANRE O42506; HXA9A_TAKRU Q1KKZ3; HXA9B_TAKRU Q9IA26; HXA9_HETFR Q9PWD5; HXA9_MORSA P50209; HXA9_AMBME A10 P31260; HXA10_HUMAN P31310; HXA10_MOUSE Q8AWY2; HXAAB_DANRE Q1KL16; HXAAA_TAKRU Q1KKZ4; HXAAB_TAKRU Q9IA27; HXA10_HETFR Q9PWD6; HXA10_MORSA A11 P31270; HXA11_HUMAN P31311; HXA11_MOUSE P31258; HXA11_CHICK Q9DDU0; HXABA_DANRE Q9DDU1; HXABB_DANRE Q9DDU2; HXABB_DEVAE Q1KL17; HXABA_TAKRU Q1KKZ5; HXABB_TAKRU A13 P31271; HXA13_HUMAN Q62424; HXA13_MOUSE Q90X25; HXA13_CHICK Q6W990; HXADA_DANRE P79724; HXADB_DANRE Q1KL22; HXADA_TAKRU Q1KKZ6; HXADB_TAKRU P50210; HXA13_AMBME B1 A2D4R4; HXB1_ATEGE P14653; HXB1_HUMAN A2D649; HXB1_MACMU A2T6H5; HXB1_MACNE P17919; HXB1_MOUSE A1YG01; HXB1_PANPA A2T6Z0; HXB1_PANTR A2T7J2; HXB1_PONPY P31259; HXB1_CHICK O42366; HXB1A_DANRE Q90423; HXB1B_DANRE Q90346; HXB1_CYPCA Q1KKX5; HXB1A_TAKRU Q1KKW8; HXB1B_TAKRU P31357; HXB1_AMBME B2 P14652; HXB2_HUMAN P0C1T1; HXB2_MOUSE O42367; HXB2A_DANRE Q6IEI0; HXB2A_TAKRU P09638; HXB2_SALSA B3 P14651; HXB3_HUMAN P09026; HXB3_MOUSE P23682; HXB3_CHICK O42368; HXB3A_DANRE Q1KKX7; HXB3A_TAKRU P31247; HXB3_XENLA B4 Q08DG5; HXB4_BOVIN P17483; HXB4_HUMAN P10284; HXB4_MOUSE P14840; HXB4_CHICK P22574; HXB4A_DANRE O13074; HXB4A_TAKRU P09070; HXB4_XENLA B5 P09067; HXB5_HUMAN P09079; HXB5_MOUSE P14157; HXB5_SHEEP P14838; HXB5_CHICK P09014; HXB5A_DANRE P09013; HXB5B_DANRE Q1KKX9; HXB5A_TAKRU Q1KKX0; HXB5B_TAKRU P09019; HXB5_XENLA B6 P17509; HXB6_HUMAN P09023; HXB6_MOUSE P14839; HXB6_CHICK P15861; HXB6A_DANRE Q9YGT4; HXB6B_DANRE Q1KKY0; HXB6A_TAKRU Q1KKX1; HXB6B_TAKRU P31256; HXB6_XENLA B7 Q9TT89; HXB7_BOVIN A1YFA5; HXB7_GORGO P09629; HXB7_HUMAN P09024; HXB7_MOUSE P18864; HXB7_RAT Q8AWY9; HXB7A_DANRE Q91771; HXB7A_XENLA P04476; HXB7B_XENLA B8 P17481; HXB8_HUMAN P09632; HXB8_MOUSE P09078; HXB8_PIG P18863; HXB8_RAT P23681; HXB8_CHICK Q8AWZ0; HXB8A_DANRE Q8JH55; HXB8B_DANRE Q1KKY1; HXB8A_TAKRU B9 P17482; HXB9_HUMAN P20615; HXB9_MOUSE Q9PWM2; HXB9A_DANRE Q1KKY2; HXB9A_TAKRU P31272; HXB9_XENLA B10 Q9PWL7; HXBAA_DANRE B13 Q92826; HXB13_HUMAN P70321; HXB13_MOUSE Q1ECY2; HXBDA_DANRE Q1KKY3; HXBDA_TAKRU C1 Q98SH9; HXC1A_DANRE C3 P28174; HXC3A_DANRE C4 P09017; HXC4_HUMAN Q08624; HXC4_MOUSE P18865; HXC4_RAT Q9PWM3; HXC4A_DANRE Q1KKU6; HXC4A_TAKRU Q9PVS4; HXC4_ORYLA C5 Q00444; HXC5_HUMAN P32043; HXC5_MOUSE P09074; HXC5A_DANRE Q1KKU7; HXC5A_TAKRU P31262; HXC5_NOTVI P09020; HXC5_XENLA C6 P09630; HXC6_HUMAN P10629; HXC6_MOUSE P49925; HXC6_SHEEP P15862; HXC6A_DANRE Q9PWM5; HXC6B_DANRE O42504; HXC6A_TAKRU P14858; HXC6_NOTVI P02832; HXC6_XENLA C8 P31273; HXC8_HUMAN P09025; HXC8_MOUSE P18866; HXC8_RAT Q9YH13; HXC8_CHICK Q68EH7; HXC8A_DANRE O42503; HXC8A_TAKRU C9 P31274; HXC9_HUMAN P09633; HXC9_MOUSE Q28601; HXC9_SHEEP Q9YGS6; HXC9A_DANRE O42502; HXC9A_TAKRU Q9PVQ9; HXC9_ORYLA C10 Q9NYD6; HXC10_HUMAN A2D635; HXC10_MACMU A2T6F8; HXC10_MACNE P31257; HXC10_MOUSE A2T7H7; HXC10_PONPY Q1KKV1; HXCAA_TAKRU C11 O43248; HXC11_HUMAN P31313; HXC11_MOUSE Q58EL0; HXCBA_DANRE Q1KKV2; HXCBA_TAKRU C12 P31275; HXC12_HUMAN Q8K5B8; HXC12_MOUSE Q9YGT0; HXCCB_DANRE Q1KKV3; HXCCA_TAKRU C13 P31276; HXC13_HUMAN P50207; HXC13_MOUSE Q6JIY5; HXCDA_DANRE Q6JIY4; HXCDB_DANRE Q1KKV4; HXCDA_TAKRU D1 Q9GZZ0; HXD1_HUMAN Q01822; HXD1_MOUSE P13544; HXD1_CHICK Q08820; HXD1_XENLA D3 P31249; HXD3_HUMAN P09027; HXD3_MOUSE P18867; HXD3_RAT P14158; HXD3_SHEEP O42370; HXD3A_DANRE A8DT10; HXD3_HAPBU Q1KKS7; HXD3A_TAKRU Q3V5Z9; HXD3_ORYLA A1L2P5; HXD3_XENLA D4 A2D4P8; HXD4_ATEGE A1YER7; HXD4_GORGO P09016; HXD4_HUMAN A2D5I1; HXD4_LAGLA P10628; HXD4_MOUSE A1YFY3; HXD4_PANPA A2T6X6; HXD4_PANTR A1YFD8; HXD4_SAGLB P14159; HXD4_SHEEP P17278; HXD4_CHICK O57374; HXD4A_DANRE Q1KKS8; HXD4A_TAKRU Q1KKR6; HXD4B_TAKRU D5 Q9IA11; HXD5_HETFR D8 P13378; HXD8_HUMAN P23463; HXD8_MOUSE A2T748; HXD8_PANTR P23459; HXD8_CHICK Q9IA12; HXD8_HETFR D9 P28356; HXD9_HUMAN P28357; HXD9_MOUSE B5DFK3; HXD9_RAT P24340; HXD9_CHICK Q9PWM6; HXD9A_DANRE Q1KKS9; HXD9A_TAKRU Q1KKR7; HXD9B_TAKRU Q9IA13; HXD9_HETFR Q9PVR2; HXD9_ORYLA D10 P28358; HXD10_HUMAN A2D5V0; HXD10_LAGLA P28359; HXD10_MOUSE A2T7D1; HXD10_PANTR A1YFT7; HXD10_SAGLB P24341; HXD10_CHICK Q90469; HXDAA_DANRE Q1KKT0; HXDAA_TAKRU Q9IA14; HXD10_HETFR D11 P31277; HXD11_HUMAN P23813; HXD11_MOUSE P24342; HXD11_CHICK Q90470; HXDBA_DANRE Q1KKT1; HXDBA_TAKRU Q1KKR8; HXDBB_TAKRU Q9IA15; HXD11_HETFR P31263; HXD11_NOTVI D12 Q5EU40; HXD12_CARPS P35452; HXD12_HUMAN P23812; HXD12_MOUSE P24343; HXD12_CHICK Q90471; HXDCA_DANRE Q1KKT2; HXDCA_TAKRU Q9IA16; HXD12_HETFR D13 Q5EU41; HXD13_CARPS P35453; HXD13_HUMAN P70217; HXD13_MOUSE P24344; HXD13_CHICK Q90472; HXDDA_DANRE Q9IA17; HXD13_HETFR Hox sequences in Drosophila and other invertebrates --------------------------------------------------- Abd-A P29555; ABDA_DROME P29552; ABDA_AEDAE P15856; ABDA_APIME Q26430; ABDA_MANSE P29556; ABDA_SCHGR Q07961; ABDA_TRICA Q05007; ABDA_ARTSF Abd-B P09087; ABDB_DROME AntP P02833; ANTP_DROME Q24645; ANTP_DROSU Dfd P07548; DFD_DROME lab P10105; LAB_DROME pb P31264; HMPB_DROME Scr P09077; SCR_DROME P15859; SCR_APIME Ubx P05048; UBX_DROFU Q23946; UBX_DROHY P83949; UBX_DROME P20822; UBX_DROPS P83950; UBX_DROSI Q24703; UBX_DROVI Q8T940; UBX_JUNCO Q25451; UBX_MUSDO Hox3 P50901; HOX3_BRAFL ----------------------------------------------------------------------- Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License -----------------------------------------------------------------------