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bloodgrp.txt

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        UniProt - Swiss-Prot Protein Knowledgebase
        SIB Swiss Institute of Bioinformatics; Geneva, Switzerland
        European Bioinformatics Institute (EBI); Hinxton, United Kingdom
        Protein Information Resource (PIR); Washington DC, USA
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Description: Blood group antigen proteins: list of entries
Name:        bloodgrp.txt
Release:     2017_11 of 22-Nov-2017

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This file is a  summary  of the  human proteins that  are responsible for the
molecular basis of the blood group antigens. Blood group antigens are surface
markers on the  outside  of  the  red  blood  cell membrane. Most of them are
proteins, but some are carbohydrates attached to lipids or proteins.

A good source of information on blood group antigens can be found in:

 Reid M.E., Lomas-Francis C.
 The Blood Group Antigen FactsBook
 Academic Press, London / San Diego, (1997).

Blood group antigen mutation database:

 http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/home


____________   _______________________________________________________________
Blood Group    Carrier or effector protein name
system         Gene name
               Swiss-Prot cross reference
               Antigen names
____________   _______________________________________________________________

ABO            Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
               (EC 2.4.1.40) (Histo-blood group A transferase) /
               Fucosylglycoprotein 3-alpha-galactosyltransferase (EC 2.4.1.37)
               (Histo-blood group B transferase).
               Gene: ABO
               BGAT_HUMAN  (P16442)

               Antigens: A/B


Chido/Rodgers  Complement C4.
               Gene: C4A and C4B
               CO4A_HUMAN  (P0C0L4)
               CO4B_HUMAN  (P0C0L5)

               Antigens: Ch1 to Ch6, WH, Rg1, Rg2


Colton         Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Water channel protein
               for red blood cells and kidney proximal tubule) (Urine
               water channel).
               Gene: AQP1; CHIP28
               AQP1_HUMAN  (P29972)

               Antigens: Co(a/b)


Cromer         Complement decay-accelerating factor (CD55 antigen).
               Gene: DAF; CD55
               DAF_HUMAN  (P08174)

               Antigens: Cr(a), Dr(a), Es(a), Tc(a/b/c), Wd(a), WES(a/b),
                         IFC, UMC, GUTI


Diego          Band 3 anion transport protein (Anion exchange protein 1)
               (AE 1) (Solute carrier family 4 member 1) (CD233 antigen).
               Gene: SLC4A1; AE1; EPB3; DI
               B3AT_HUMAN  (P02730)

               Antigens: Di(a/b), FR(a/a+), Wr(a/b), Wd(a), Rb(a), WARR, ELO,
                         BOW, Wu, Vg(a), Bp(a), Hg(a), Mo(a), Sw(a), Tr(a)


Dombrock       Ecto-ADP-ribosyltransferase 4 (EC 2.4.2.31) (NAD(P)(+)--
               arginine ADP-ribosyltransferase 4) (Mono(ADP-ribosyl)
               transferase 4) (Dombrock blood group carrier molecule) (CD97
               antigen).
               Gene: ART4; D0; DOK1
               NAR4_HUMAN  (Q93070)

               Antigens: Do(a/b), Gy(a), Hy, Jo(A)


Duffy          Duffy antigen (Fy glycoprotein) (Glycoprotein D) (GpFy)
               (CD234 antigen).
               Gene: FY; GPD; DARC
               ACKR1_HUMAN (Q16570)

               Antigens: Fy(a/b)


Gerbich        Glycophorin-C (PAS-2') (Glycoprotein beta) (Glycoconnectin)
               (Sialoglycoprotein-D) (Glycophorin-D) (GpD).
               Gene: GYPC; GPC
               GLPC_HUMAN  (P04921)

               Antigens: An(a), Dh(A), Ls(a), Wb


GIL            Aquaporin-3 (AQP-3).
               Gene: AQP3
               AQP3_HUMAN  (Q92482)


Hh             Galactoside 2-L-fucosyltransferase 1 (EC 2.4.1.69)
               (Alpha(1,2)Ft 1) (Fucosyltransferase 1).
               Gene: FUT1
               FUT1_HUMAN  (P19526)

               Galactoside 2-L-fucosyltransferase 2 (EC 2.4.1.69)
               (Alpha(1,2)Ft 2) (Fucosyltransferase 2) (Secretor factor).
               Gene: FUT2
               FUT2_HUMAN  (Q10981)

               Antigens: H/h, Se/se


Indian         CD44 antigen (Phagocytic glycoprotein I) (PGP-1) (Hutch-I)
               (Extracellular matrix receptor-III) (ECMR-III) (Hermes antigen)
               (Hyaluronate receptor) (Heparan sulfate proteoglycan) (Epican).
               Gene: CD44; LHR
               CD44_HUMAN  (P16070)

               Antigens: In(a/b)


John-Milton-   Semaphorin-7A (Semaphorin-L) (Sema L) (Semaphorin-K1)
Hargen         (Sema K1) (CD108 antigen) (CDw108).
               Gene: SEMA7A; SEMAL; CD108
               SEM7A_HUMAN (O75326)


Kell           Kell blood group glycoprotein (EC 3.4.24.-) (CD238 antigen).
               Gene: KEL
               KELL_HUMAN  (P23276)

               Antigens: K/k, Kp(a/b/c), Js(a/b), Ul(a), KEL11/17, KEL14/24


Kidd           Urea transporter, erythrocyte.
               Gene: SLC14A1; HUT11; JK; RACH1; UT1; UTE
               UT1_HUMAN   (Q13336)

               Antigens: Jk(a/b)


Knops          Complement receptor type 1 (C3b/C4b receptor) (CD35 antigen).
               Gene: CR1; C3BR
               CR1_HUMAN   (P17927)

               Antigens: Kn(a/b), McC(a), Sl(a), Vl, Yk(a)


Kx             Membrane transport protein XK (Kx antigen).
               Gene: XK
               XK_HUMAN    (P51811)


Landsteiner-   Intercellular adhesion molecule-4 (ICAM-4)
Wiener         (Landsteiner-Wiener blood group glycoprotein) (LW blood
               group protein) (CD242 antigen).
               Gene: ICAM4; LW
               ICAM4_HUMAN (Q14773)

               Antigens: LW(a/b)


Lewis          Galactoside 3(4)-L-fucosyltransferase (EC 2.4.1.65)
               (Fucosyltransferase 3) (FUCT-III).
               Gene: FUT3; LE
               FUT3_HUMAN  (P21217)

               Antigens: Le(a/b)


Lutheran       Lutheran blood group glycoprotein (B-CAM cell surface
               glycoprotein) (Auberger B antigen) (F8/G253 antigen)
               (CD239 antigen).
               Gene: BCAM; LU; MSK19
               BCAM_HUMAN    (P50895)

               Antigens: Lu(a/b), Au(a/b), LU6 to LU20


MNS            Glycophorin-A (PAS-2) (Sialoglycoprotein alpha) (MN
               sialoglycoprotein) (CD235a antigen).
               Gene: GYPA; GPA
               GLPA_HUMAN  (P02724)

               Glycophorin-B (PAS-3) (Sialoglycoprotein delta) (SS-active
               sialoglycoprotein) (CD235b anrigen).
               Gene: GYPB; GPB
               GLPB_HUMAN  (P06028)

               Antigens: M/N, S/s, U, He, Mi(a), M(c), Vw, Mur, M(g), Vr,
                         M(e), Mt(a), St(a), Ri(a), Cl(a), Ny(a), Hut, Hil,
                         M(v), Far, Mit, Dantu, Hop, Nob, En(a), ENKT, etc.



OK             Basigin (Leukocyte activation antigen M6) (Collagenase
               stimulatory factor) (Extracellular matrix metalloproteinase inducer)
               (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor)
               (TCSF) (OK blood group antigen) (CD147 antigen).
               Gene: BSG
               BASI_HUMAN  (P35613)

               Antigen: Ok


P              UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
               (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-
               GalTase 3) (Beta3Gal-T3) (b3Gal-T3)
               (Galactosylgalactosylglucosylceramide beta-D-acetyl-
               galactosaminyltransferase) (Globoside synthase).
               Gene: B3GALN1; B3GALT3
               B3GL1_HUMAN (O75752)

               Antigens: P1


RAPH           CD151 antigen (Platelet-endothelial tetraspan antigen 3)
               (PETA-3) (GP27) (Membrane glycoprotein SFA-1) (Tetraspanin-24)
               (Tspan-24).
               Gene: CD151; TSPAN24
               CD151_HUMAN (P48509)

               Antigens: MER2


Rh             Blood group RH(CE) polypeptide (Rhesus C/E antigens) (RHPI)
               (CD240CE antigen).
               Gene: RHCE; RHC; RHE
               RHCE_HUMAN  (P18577)

               Blood group RH(D) polypeptide (Rhesus D antigen) (RHPII)
               (CD240D antigen).
               Gene: RHD
               RHD_HUMAN   (Q02161)

               Antigens: C/c, E/e, D, f, C(e), C(w), C(x), V, E(w), G, Tar,
                         VS, D(w), cE, etc.


Scianna/       Erythroid membrane-associated protein (hERMAP) (Scianna
Radin          blood group antigen) (Radin blood group antigen).
               Gene: ERMAP; RD; SC
               ERMAP_HUMAN (Q96PL5)

               Antigens: Sc(1/2), Sc3, Sc4/Rd, Sc5/STAR, Sc6/SCER, Sc7/SCAN


Vel            Small integral membrane protein 1 (Vel blood group
               antigen).
               Gene: SMIM1
               SMIM1_HUMAN (B2RUZ4)

               Antigens: Vel

Xg             Glycoprotein Xg (Protein PBDX).
               Gene: XG; PBDX
               XG_HUMAN    (P55808)

               Antigens: Xg(a)


Yt             Acetylcholinesterase (EC 3.1.1.7) (AChE).
               Gene: ACHE
               ACES_HUMAN  (P22303)

               Antigens: Yt(a/b)

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