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Definition

A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG51 is a non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest motor and posture impairments often associated with epilepsy and disturbances of cognition, behavior, sensation, and communication.

Acronym

SPG51

Synonyms

Cerebral palsy, spastic quadriplegic 4
CPSQ4

Keywords

Hereditary spastic paraplegia