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Definition

A complex neurodegenerative disorder with manifestations ranging from typical Parkinson disease to dementia with Lewy bodies. Clinical features include parkinsonian symptoms (resting tremor, rigidity, postural instability and bradykinesia), dementia, diffuse Lewy body pathology, autonomic dysfunction, hallucinations and paranoia.

Acronym

PARK4

Synonyms

Parkinson disease 4 autosomal dominant Lewy body
Parkinson disease autosomal dominant 4
Parkinson disease familial type 4

Keywords

Neurodegeneration
Parkinson disease
Parkinsonism

 
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